Thermo-sensitive and long-acting antibacterial arginine-group hydrogel dressing and preparation method thereof
An arginine-based, temperature-sensitive technology, applied in medical science, bandages, absorbent pads, etc., can solve problems such as poor results, achieve good biocompatibility, long-term stable antibacterial function, and reduce replacement frequency Effect
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Embodiment 1
[0046] a) Preparation of modified arginine hydrogel monomer:
[0047] Preparation of modified arginine monomer: put 0.1mol of L-arginine, 0.2mol of sodium bicarbonate and 100ml of distilled water in a round bottom flask, cool to 0°C, and add 0.12 mol of methacrylic anhydride, after stirring for 1.5 h, the pH of the solution was adjusted to 7.4 with dilute sodium hydroxide solution. Then filter and wash with CH 2 Cl 2 Wash three times to remove impurities and unreacted raw materials, and finally freeze-dry at -50°C under vacuum to obtain a white powder solid, which is the modified arginine monomer (M-Arg).
[0048] b) Preparation of broad-spectrum antibacterial drug polyhexamethyleneguanidine hydrochloride:
[0049] Add guanidine hydrochloride and hexamethylenediamine into an electric stirrer at a molar ratio of 1:1, and react at 100°C for 1 hour (the ammonia gas produced by the reaction is introduced into the HCl solution for neutralization), and when the ammonia gas export...
Embodiment 2
[0055] a) Preparation of hydrogel monomer with durable antibacterial function:
[0056] Preparation of modified arginine monomer: put 0.1mol of L-arginine, 0.2mol of sodium bicarbonate and 100ml of distilled water in a round bottom flask, cool to 0°C, and add 0.12 mol of methacrylic anhydride, after stirring for 1.5 h, the pH of the solution was adjusted to 7.4 with dilute sodium hydroxide solution. Then filter and wash with CH 2 Cl 2 Wash three times to remove impurities and unreacted raw materials, and finally freeze-dry at -50°C under vacuum to obtain a white powder solid, which is the modified arginine monomer.
[0057] Add guanidine hydrochloride and hexamethylenediamine into an electric stirrer at a molar ratio of 1:1, and react at 100°C for 1 hour (the ammonia gas produced by the reaction is introduced into the HCl solution for neutralization), and when the ammonia gas export speed is slow, raise the temperature to 180°C, continue the reaction for 6 hours, stop the t...
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