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A thermosensitive arginine-based long-acting antibacterial hydrogel dressing and preparation method thereof

An arginine-based, temperature-sensitive technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as poor results, achieve good biocompatibility, long-term stable antibacterial function, and reduce replacement frequency Effect

Active Publication Date: 2018-12-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies have reported that dressings are endowed with antibacterial or antibacterial functions by impregnation, coating and other methods to improve the anti-harmful microbial performance of dressings, but the results are not good

Method used

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  • A thermosensitive arginine-based long-acting antibacterial hydrogel dressing and preparation method thereof
  • A thermosensitive arginine-based long-acting antibacterial hydrogel dressing and preparation method thereof
  • A thermosensitive arginine-based long-acting antibacterial hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] a) Preparation of modified arginine hydrogel monomer:

[0047] Preparation of modified arginine monomer: put 0.1mol of L-arginine, 0.2mol of sodium bicarbonate and 100ml of distilled water in a round bottom flask, cool to 0°C, and add 0.12 mol of methacrylic anhydride, after stirring for 1.5 h, the pH of the solution was adjusted to 7.4 with dilute sodium hydroxide solution. Then filter and wash with CH 2 Cl 2 Wash three times to remove impurities and unreacted raw materials, and finally freeze-dry at -50°C under vacuum to obtain a white powder solid, which is the modified arginine monomer (M-Arg).

[0048] b) Preparation of broad-spectrum antibacterial drug polyhexamethyleneguanidine hydrochloride:

[0049] Add guanidine hydrochloride and hexamethylenediamine into an electric stirrer at a molar ratio of 1:1, and react at 100°C for 1 hour (the ammonia gas produced by the reaction is introduced into the HCl solution for neutralization), and when the ammonia gas export...

Embodiment 2

[0055] a) Preparation of hydrogel monomer with durable antibacterial function:

[0056] Preparation of modified arginine monomer: put 0.1mol of L-arginine, 0.2mol of sodium bicarbonate and 100ml of distilled water in a round bottom flask, cool to 0°C, and add 0.12 mol of methacrylic anhydride, after stirring for 1.5 h, the pH of the solution was adjusted to 7.4 with dilute sodium hydroxide solution. Then filter and wash with CH 2 Cl 2 Wash three times to remove impurities and unreacted raw materials, and finally freeze-dry at -50°C under vacuum to obtain a white powder solid, which is the modified arginine monomer.

[0057] Add guanidine hydrochloride and hexamethylenediamine into an electric stirrer at a molar ratio of 1:1, and react at 100°C for 1 hour (the ammonia gas produced by the reaction is introduced into the HCl solution for neutralization), and when the ammonia gas export speed is slow, raise the temperature to 180°C, continue the reaction for 6 hours, stop the t...

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Abstract

The invention relates to a thermo-sensitive and long-acting antibacterial arginine-group hydrogel dressing and a preparation method thereof. Antibacterial drugs are distributed on the surface of and inside hydrogel. The preparation method comprises steps as follows: L-arginine and sodium bicarbonate are dissolved in distilled water, methacrylic anhydride is dropwise added at 0 DEG C, the mixture is stirred, the pH of the solution is adjusted to be 7.4, the solution is filtered and washed, and a modified arginine monomer (M-Arg) is acquired; two antibacterial drugs, namely, A and B, are combined with an N-isopropylacrylamide monomer and a modified arginine monomer with chemical grafting and drug preloading methods, thermo-sensitive and long-acting antibacterial arginine-group hydrogel is obtained and combined with a matrix, and the thermo-sensitive and long-acting antibacterial arginine-group hydrogel dressing is obtained. Raw materials have good biocompatibility, and the obtained hydrogel dressing has thermosensitivity, can resist bacteria and protein absorption, has a long-acting antibacterial function and is suitable for wound protection and treatment of burns, scalds and traumatic injuries.

Description

technical field [0001] The invention belongs to the field of medical materials and their preparation, in particular to a thermosensitive arginine-based long-acting antibacterial hydrogel dressing and a preparation method thereof. Background technique [0002] Wound healing is a dynamic process, and the performance of dressings can alter the progress of healing. The development of dressings has experienced traditional linen, suet, passive gauze, cotton, and gauze pads, and gradually researched and invented new types of airtight and semi-occlusive dressings. With the acceleration of people's life rhythm and the increase of work pressure, time is becoming more and more important to most people. Traditional and passive dressings cannot promote wound healing due to their existence, and the wound healing time is long, and they are easy to stick to the wound when used. Secondary injury, poor hemostasis, susceptibility to infection, large amount of dressing and many other disadvant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/44A61L15/42
CPCA61L15/24A61L15/42A61L15/44A61L2300/204A61L2300/206A61L2300/404A61L2300/45C08L33/26
Inventor 吴德群张俊芝徐海玲吴飞飞汤双双俞建勇
Owner DONGHUA UNIV
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