Preparation method of self-adhesion electroconductive hydrogel

A conductive hydrogel and self-adhesion technology, applied in the field of preparation of self-adhesive conductive hydrogel, can solve problems such as increasing complexity, and achieve the effects of good biocompatibility, fast polymerization speed, and increased dispersibility

Active Publication Date: 2016-08-31
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, existing conductive hydrogels need to rely on addit

Method used

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  • Preparation method of self-adhesion electroconductive hydrogel
  • Preparation method of self-adhesion electroconductive hydrogel
  • Preparation method of self-adhesion electroconductive hydrogel

Examples

Experimental program
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Embodiment 1

[0041] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0042] A, preparation of double-bonded silk fibroin:

[0043] A1: Weigh silk fibroin and dissolve it in water to prepare a solution with a concentration of 2%;

[0044] A2: Slowly add methacrylic anhydride 0.8 times the amount of silk fibroin into the biomacromolecule solution, and then stir and react at 50°C for 24 hours;

[0045] A3: Dilute the reaction solution of silk fibroin and methacrylic anhydride 5 times;

[0046] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12-14 kDa, and dialyze with deionized water to obtain a double-bonded silk fibroin solution;

[0047]A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at 2500rpm for 15 minutes, and freeze-dry the obtained centrifuged precipitate to obtain double-bonded silk fibroin powder.

[0048] B. Preparation of polydopamine-functionalized conductive nanomater...

Embodiment 2

[0056] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0057] A, prepare double-bonded chitosan:

[0058] A1: Take chitosan and dissolve it in phosphate buffer solution to prepare a solution with a mass concentration of 1%;

[0059] A2: Slowly add methacrylic anhydride 0.16 times the mass of chitosan to the biomacromolecule solution dropwise, then stir and react at 25°C for 24 hours;

[0060] A3: subsequently dilute the reaction solution of chitosan biomacromolecule and methacrylic anhydride 5 times;

[0061] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12 to 14 kDa, and dialyze with deionized water to obtain a double-bonded chitosan solution;

[0062] A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at a speed of 2500 rpm for 15 minutes, and freeze-dry the resulting centrifuged precipitate to obtain a double-bonded chitosan powder.

[0063] B. Preparation of poly...

Embodiment 3

[0071] A preparation method of self-adhesive conductive hydrogel, comprising the following steps:

[0072] A. Preparation of double bonded gelatin:

[0073] A1: Weigh gelatin and dissolve it in phosphate buffer solution to obtain a solution with a gelatin mass concentration of 10%;

[0074] A2: Slowly add glycidyl methacrylate 17.5 times the mass of gelatin to the biomacromolecule solution dropwise, then stir and react at 50°C for 3 hours;

[0075] A3: Then dilute the reaction solution of gelatin and methacrylic anhydride 5 times;

[0076] A4: Place the solution diluted in step A4 in a dialysis bag with a molecular weight cut-off of 12-14 kDa, and dialyze with deionized water to obtain a double-bonded gelatin solution;

[0077] A5: Pour the dialyzed solution into a centrifuge tube, centrifuge at 2500 rpm for 15 minutes, and freeze-dry the resulting centrifuged precipitate to obtain double-bonded gelatin powder.

[0078] B. Preparation of polydopamine-functionalized conducti...

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Abstract

The invention discloses a preparation method of self-adhesion electroconductive hydrogel and belongs to the technical field of biomaterial preparation. The preparation method includes following steps: introducing double bonds on biomacromolecules through methyl acrylic anhydridization to obtain double-bond biomacromolecules; preparing a polydopamine-functionalized electroconductive nano material, and polymerizing the double-bond biomacromolecules and the polydopamine-functionalized electroconductive nano material through photo-initiated free radicals to obtain the self-adhesive electroconductive hydrogel. With reference to adhesiveness of mussel-imitated materials, phenolic hydroxyl functional group with adhesiveness is introduced, and regulation of self-adhesion performance of the hydrogel is realized by changing content of the phenolic hydroxyl functional group. In addition, the self-adhesion electroconductive hydrogel prepared by the method has high electroconductivity, mechanical performance and biocompatibility, and application range of the hydrogel is widened. The preparation method has the advantages of being simple and easy to implement, controllable in polymerization process, high in polymerization speed and low in energy consumption.

Description

technical field [0001] The invention belongs to the technical field of biomaterial preparation, and in particular relates to a preparation method of a self-adhesive conductive hydrogel with good mechanical properties, electrical conductivity and biocompatibility. Background technique [0002] Smart hydrogels are a class of hydrogels that can respond to changes in external stimulus signals (such as temperature, pH, solvent, ionic strength, electric field, magnetic field, pressure, and specific molecules, etc.). Conductive hydrogel is a kind of smart hydrogel. It combines the dual characteristics of hydrogel and conductive material, and has a controllable conductivity range. Therefore, it is widely used in artificial electronic skin, wearable bioelectronic devices, and cardiac tissue engineering. There are potential applications in areas such as materials and biosensors. [0003] At present, conductive hydrogels are mainly composed of conductive nanoparticles or conductive po...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08G81/00C08F289/00C08F251/00C08L79/04C08K3/04
CPCC08F251/00C08F289/00C08G81/00C08G2210/00C08J3/075C08J2387/00C08J2479/04C08K3/04C08K2201/001C08K2201/011C08F220/08
Inventor 鲁雄韩璐甘东林刘柯志王振铭谢超鸣
Owner SOUTHWEST JIAOTONG UNIV
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