The invention discloses a clear isolation cream. The clear isolation cream contains propylene glycol, butanediol, glycine betaine, sodium chloride, magnesium sulfate, methyl parahydroxybenzoats, para hydroxybenzene propyl ester, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, cetyl PEG/PPG-10/1 polydimethylsiloxane, Dimeticone, caprylic acid, triglyceride fatty acid, shea butter, microcrystalline wax, beeswax, polydimethylsiloxane, grape seed oil, sodium hyaluronate, essence, arbutin, adenosine, allantoin, iron oxide yellow, iron oxide red, black iron oxide and water. The evaluation of users and the result of test on the skin of the users show that the isolation cream has better isolation effect, the cream preparation is light and breathable, and the clear isolation cream can effectively isolate harmful matters in make-up products and the air, block ultraviolet rays, protect the skin from being hurt without blocking pores, and can keep the skin supple and full.