Traditional Chinese medicine composition for treating uterine incision diverticulum
By using the oral administration of traditional Chinese medicine composition, enema liquid and ginger therapy package, the multi-dimensional synergistic effect on the uterine incision diverticulum is solved, and the side effects and high recurrence rates of existing Western medical treatment methods are achieved, and effective therapeutic effects are achieved.
Patent Information
- Application Number
- CN202411470640.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-21
- Publication Date
- 2025-02-07
AI Technical Summary
The existing Western medical treatment methods have side effects and high recurrence rates for diverticulum in uterine incisions, and it is difficult to effectively solve the symptoms caused by diverticulum such as prolonged menstrual period and pain in the long run.
A Chinese medicine composition is adopted, including oral medication, enema liquid and ginger therapy package. Through the effects of evacuating evil qi, promoting blood circulation and removing blood stasis, clearing heat and detoxifying, and regulating qi and blood, it acts on the lesions in multiple dimensions and is used to treat diverticula in uterine incisions.
The effect of treating diverticulum in uterine incision is achieved, with shorter menstrual periods, good pain relief, quick results, no obvious side effects, and significant long-term effects.
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating uterine incisional diverticulum. Background Art
[0002] Uterine incision diverticulum refers to a cystic structure that appears in the area of the surgical incision of the uterus (such as a cesarean section incision). This diverticulum may be caused by factors such as poor tissue healing, incision infection, or abnormal placenta implantation. The reasons for its formation are as follows: first, poor healing of the incision during cesarean section may be caused by improper suturing technique or excessive force on the incision; second, postoperative infection will affect wound healing and lead to the formation of diverticula; third, ischemia, necrosis or inflammation of local tissues can lead to poor incision healing, thereby forming a diverticula; fourth, conditions such as placenta previa may also lead to structural abnormalities at the incision site.
[0003] Diverticula may cause symptoms such as abdominal pain, vaginal bleeding or infection, and prolonged menstruation; in some cases, diverticula may affect subsequent pregnancy or delivery, especially if the diverticula are large or inappropriately located, which may lead to complications at the incision site, such as infection, scar formation, etc. Chronic conditions may affect the patient's mental health, causing anxiety or depression.
[0004] The existing Western medical treatment method is to use contraceptives such as Marvelon to relieve the prolonged menstruation caused by uterine incision diverticulum by regulating hormone levels in the body, inhibiting endometrial growth and improving menstrual regularity. This drug helps to reduce abnormal bleeding and dysmenorrhea, make the menstrual cycle more regular, and thus improve the discomfort caused by diverticulum. Although it is effective in the short term, it has side effects and is prone to recurrence. Summary of the invention
[0005] In order to solve the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating uterine incision diverticulum. The traditional Chinese medicine composition prescription for treating uterine incision diverticulum has the effects of dispersing evil spirits, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and regulating qi and blood. The present invention promotes the release of effective ingredients, and can not affect the synergistic effects of clearing heat and toxins, relieving liver depression, and harmonizing internal organs among medicinal materials to a greater extent, and has better effects on treating infection and inflammation; the present invention acts synergistically on the lesion in multiple dimensions through oral administration, ginger therapy, and enema, and is used for the treatment of uterine incision diverticulum, shortening menstruation, having good analgesic effect, and taking effect quickly.
[0006] In order to achieve the above object, the present invention adopts the following technical solution:
[0007] A Chinese medicine composition for treating uterine incisional diverticulum, the Chinese medicine composition comprising an oral medicine, an enema solution and a ginger treatment bag, wherein the oral medicine is prepared from the following raw materials in parts by weight:
[0008] 8-12 parts of Herba Lycopodii, 12-18 parts of Radix Paeoniae Alba, 8-15 parts of Radix Bupleuri, 12-18 parts of Fructus Lycopodii, 12-18 parts of Caulis Millettiae, 12-18 parts of Codonopsis Pilosulae, 12-18 parts of Rhizoma Atractylodis Macrocephalae, 12-18 parts of Radix Astragali, 12-18 parts of Radix Trichosanthis, 8-12 parts of Rheum Officinale, 8-12 parts of Platycodon Grandiflorum, 12-18 parts of Caulis Honeysuckle, 1-5 parts of Sanguisorba Officinalis, 8-12 parts of Cinnamomum cassia, and 8-12 parts of Fenugreek;
[0009] The enema solution is made of the following raw materials in parts by weight:
[0010] 8-12 parts of cinnamon twig, 8-12 parts of radix scutellariae, 8-12 parts of asarum, 12-18 parts of rhizoma smilacis, 8-12 parts of fructus toosendan, 8-12 parts of radix bupleuri, 8-12 parts of herba schizonepetae, 8-12 parts of fennel, 8-12 parts of lindera, 12-18 parts of herba patriniae, 12-18 parts of scutellariae, 12-18 parts of rhizoma lychees, 12-18 parts of herba rubrae, 8-12 parts of rhizoma ligustici;
[0011] The ginger therapy bag is made of the following raw materials in parts by weight:
[0012] 12-18 parts of dried ginger, 8-12 parts of Qiannianjian, 8-12 parts of Zhuidifeng, 8-12 parts of Qianghuo, 8-12 parts of Duhuo, 8-12 parts of Zanthoxylum, 8-12 parts of Angelica dahurica, 8-12 parts of Chuanxiong, 8-12 parts of Aconitum, 8-12 parts of Lycopodiella cuneata, 8-12 parts of Artemisia argyi, 8-12 parts of Asarum, 8-12 parts of Borneolum, 8-12 parts of Cassia twig, 8-12 parts of fennel, and 8-12 parts of Escherichia corydalis.
[0013] Preferably, the oral medicine is made of the following raw materials in parts by weight:
[0014] 10 parts of Herba Lycopodii, 15 parts of Radix Paeoniae Alba, 12 parts of Radix Bupleuri, 15 parts of Fructus Liquidambar, 15 parts of Caulis Millettiae, 15 parts of Codonopsis Pilosulae, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Radix Astragali, 15 parts of Radix Trichosanthis, 10 parts of Rheum Officinale, 10 parts of Platycodon Grandiflorum, 15 parts of Caulis Lonicerae, 1-5 parts of Sanguisorba Officinalis, 10 parts of Cinnamomum cassia, and 10 parts of Fenugreek.
[0015] Preferably, the enema solution is made of the following raw materials in parts by weight:
[0016] 10 parts of cinnamon twig, 10 parts of herba schizonepetae, 10 parts of asarum, 15 parts of rhizoma smilacis, 10 parts of fructus toosendan, 10 parts of radix bupleuri, 10 parts of herba schizonepetae, 10 parts of fennel, 10 parts of linderae, 15 parts of herba patriniae, 15 parts of scutellariae, 15 parts of rhizoma liquidambar formosanae, 15 parts of semen litchi, 15 parts of herba red peony roots, and 10 parts of rhizoma ligustici.
[0017] Preferably, the ginger therapy bag is made of the following raw materials in parts by weight:
[0018] 15 parts of dried ginger, 10 parts of Rhizoma Anemarrhenae, 10 parts of Herba Lycopodii, 10 parts of Rhizoma Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 10 parts of Rhizoma Aconiti Kusnezoffii, 10 parts of Herba Lycopodii, 10 parts of Folium Artemisiae Argyi, 10 parts of Asarum, 10 parts of Borneolum Syntheticum, 10 parts of Ramulus Cinnamomi, 10 parts of Fructus Cuscutae, and 10 parts of Herba Echinops.
[0019] Preferably, the preparation method of the oral medicine comprises the following steps:
[0020] Step 1: Weigh rhubarb, platycodon, dragon's blood, and fenugreek in proportion, first add 6 to 8 times the amount of water to soak for 2 to 3 hours, and then decoct for 1 to 2 hours at a decoction temperature of 80 to 100° C. After decoction, filter to obtain filtrate 1;
[0021] Step 2: Weigh Bupleurum, Smilax glabra and Astragalus according to the proportion, cut into 1-3 cm segments and set aside;
[0022] Step 3: Weigh stir-fried Atractylodes macrocephala, Radix Trichosanthis, Caulis Loniceraes, Cinnamomum cassiae and Herba Lycopodiellae according to proportion, and mix together with Radix Bupleuri, Fructus Smilacis Glabrae and Radix Astragali cut in step 2, add 6 to 8 times amount of water and boil for 2 to 3 hours at a boiling temperature of 80 to 100° C. After boiling, filter to obtain filtrate 2;
[0023] Step 4: Mix filtrate 1 and filtrate 2 evenly and fill the mixture.
[0024] Preferably, the preparation method of the enema solution comprises the following steps: weighing each Chinese medicine in proportion, mixing and crushing, soaking in water for half an hour, and then boiling twice, each time for 1 to 1.5 hours, combining the decoctions and placing them in a vacuum concentration tank to concentrate them to a relative density of 1.06 to 1.08 (60°C), standing for 24 hours, taking the supernatant and filtering it, and filling the filtrate.
[0025] Preferably, the preparation method of the ginger therapy bag comprises the following steps: first, frying the dried ginger in a pan to 40-50° C., then weighing other Chinese medicines in proportion, grinding them into powder and putting them into the pan to stir evenly, and then putting them into a non-woven bag after stirring evenly to make the ginger therapy bag.
[0026] Preferably, the method of using the oral medication, enema solution and ginger therapy bag is to first take the oral medication orally, then lie on the side, perform enema with the enema solution through enema operation, lie flat after enema, and spread the heated ginger therapy bag flat on the lower abdomen.
[0027] The pathogenesis of uterine incisional diverticulum is as follows:
[0028] Uterine incision diverticulum refers to one or more depressions that appear at the uterine incision and communicate with the uterine cavity due to healing defects after cesarean section of the lower uterine segment, and menstrual blood accumulates in the depressions. Clinical manifestations include prolonged menstruation, secondary infertility, chronic pelvic pain, chronic abdominal pain and other symptoms.
[0029] Bupleurum is pungent, bitter, and slightly cold. It enters the liver, gallbladder, and lung meridians. Bupleurum is bitter, pungent, and dispersing, aromatic, and ascending, slightly cold and can clear, and enters the liver and gallbladder meridians. It can not only disperse the evil qi in the gallbladder meridian and relieve fever, but also disperse the stagnant qi in the liver and gallbladder meridians and relieve liver and depression, and also raise the clear yang qi of the liver and gallbladder and lift the sunken qi. It is the main medicine for the liver and gallbladder meridians. It can both disperse and clear when used raw, but the ability to disperse and clear is reduced when processed with vinegar, but the ability to disperse and clear is increased while the ability to soothe the liver is increased. "Compendium of Materia Medica Volume 13": "There are five types of fatigue, and the disease is in the five internal organs. If the fatigue is in the liver, gallbladder, heart, and pericardium with heat, or the Shaoyang meridian is hot and cold, then Bupleurum is a must-use medicine for the hand and foot Jueyin and Shaoyang: if the fatigue is in the spleen and stomach with heat, or the Yang Qi is sunken, then Bupleurum is a must-use medicine to lead the clear qi and reduce fever; but if the fatigue is in the lungs and kidneys, it can be omitted. However, Dongyuan Li said that it should be added for those with heat, but not for those without heat.
[0030] Stretching grass, slightly bitter, pungent, warm. Enter the liver, spleen, kidney meridians. Good at dispelling wind and dampness, relaxing muscles and tendons, promoting blood circulation and reducing swelling. "Southern Yunnan Materia Medica" says: "It can reduce qi, eliminate the fullness and blockage in the chest, push the food in the stomach, eliminate the hard accumulation in the abdomen for a long time, and reduce edema."
[0031] Honeysuckle vine, sweet in taste, cold in nature, enters the lung and stomach meridians. Honeysuckle vine has the effects of clearing away heat and detoxifying, dispersing wind and unblocking collaterals. It is mainly used for fever caused by febrile diseases, dysentery caused by heat toxins, carbuncle, ulcer, rheumatism, heat and pain in joints. "Medicinal Properties": "It is mainly used to treat abdominal distension and can stop the downward movement of qi."
[0032] Xuejie, sweet and salty, neutral, enters the heart and liver meridians. It can not only promote blood circulation and relieve pain, treat blood syndrome; it can also dissolve blood stasis, astringe and stop bleeding, treat bleeding from trauma; it can also promote tissue regeneration, reduce swelling and heal sores, treat sores that do not heal. "Newly Revised Materia Medica" says: "The name of the tree of Qijiejie is Keliu, which is like a bee making honey, grind it and use it." "It can treat sudden pain in the heart and abdomen, bleeding from wounds, break up blood stasis, relieve pain, and promote tissue regeneration."
[0033] Rhizoma Lulutong, bitter and neutral in nature. It enters the liver and kidney meridians. Rhizoma Lulutong is pungent, dispersing, bitter and purgative, neutral and less biased, and enters the liver, stomach and bladder meridians, and not only flows through the blood, but also enters the qi. It is good at dispelling wind, unblocking meridians, promoting diuresis, relieving numbness, relieving itching, reducing swelling, and promoting lactation. It is suitable for treating arthralgia regardless of cold or heat, and is especially good for those with tendon and vein stagnation; it is suitable for treating milk deficiency or urticaria itching, regardless of cold or heat or with or without blood stasis.
[0034] Millettia reticulata, bitter, sweet, warm in nature. Enters the liver and kidney meridians. It not only promotes blood circulation and relieves pain, but also replenishes blood and relaxes muscles and relieves pain. It can be used to treat blood stasis, blood deficiency and cold symptoms. It is most suitable for those with blood deficiency, arthralgia and numbness. "New Reference for Medicinal Pieces": "Removes blood stasis, generates new blood, circulates meridians, treats heatstroke, and wind-blood arthralgia".
[0035] White peony root is bitter, sour and slightly cold. It enters the liver and spleen meridians. It has the effects of nourishing blood and regulating menstruation, restraining yin and stopping sweating, softening the liver and relieving pain, and calming liver yang. "Ben Jing": "It treats abdominal pain caused by evil qi, removes blood stasis, breaks up hard masses, treats cold and heat hernia scars, upper pain, promotes urination, and replenishes qi."
[0036] Codonopsis pilosula is sweet and mild in nature. Codonopsis pilosula is sweet and mild, not dry or greasy, and enters the spleen and lung meridians. Its ability to replenish qi is inferior to that of ginseng, and it is mostly used for mild symptoms of spleen and lung qi deficiency. It also produces body fluid and nourishes blood, and can treat symptoms such as body fluid deficiency and blood deficiency. "Compendium of Materia Medica" says: "It replenishes the middle qi, replenishes qi, harmonizes the spleen and stomach, and eliminates thirst. It is very safe to use it to regulate and replenish the middle qi, which is slightly weak.
[0037] Stir-fried Atractylodes macrocephala tastes bitter, slightly sweet, and slightly warm in nature. It warms the middle and strengthens the spleen, replenishes qi and consolidates the exterior, stops sweating, stops diarrhea, and stops pain. "Rihuazi Materia Medica": It can treat all wind diseases, five kinds of labor and seven kinds of injuries, cold abdominal distension, nourish the waist and knees, eliminate phlegm, treat water vapor, promote urination, stop nausea and vomiting, and weak tendons and bones, abdominal pain, cold marks in women, febrile diseases, mountain mist miasma, and relieve restlessness and muscle growth.
[0038] Astragalus is sweet and slightly warm in nature, and it enters the spleen and lung meridians. Astragalus is sweet and warm, and it is sweet and mild, and it is diuretic and beneficial. It is slightly warm when used raw, and warm when roasted with honey. It enters the spleen and lung meridians, and is mainly used to support the positive energy and remove water evil. It is good at replenishing the middle qi and raising the clear yang, and it is also good at replenishing the lung qi, benefiting the stomach and strengthening the exterior. It can treat spleen and lung qi deficiency, sinking of the middle qi, qi not being able to hold blood, spontaneous sweating and night sweats, etc. It can also support sores, promote diuresis and reduce swelling, and treat sores caused by insufficient qi and blood that do not ulcerate or ulcerate for a long time, as well as qi deficiency edema and urination difficulties. "Famous Doctors' Records": "It treats wind evil in women's genitals and expels bad blood between the five internal organs. It replenishes men's deficiency and thinness caused by five kinds of labor. It quenches thirst, abdominal pain, and diarrhea. It replenishes qi and benefits yin qi."
[0039] Radix Trichosanthis is sweet, slightly bitter, and slightly cold. It enters the lung and stomach meridians. It is sweet and sour, moisturizing, and clearing and dissolving ulcers. It can clear away heat, promote fluid production, and quench thirst, moisten the lungs, clear lung heat, and relieve coughs, and also dissipate lumps and ulcers, and promote the discharge of pus. "Rihuazi Bencao" says: "It clears the small intestine, discharges pus, eliminates swelling and poison, promotes muscle growth, eliminates blood stasis, and treats seasonal fever, breast abscesses, back abscesses, hemorrhoids, fistulas, and furuncles."
[0040] Rhubarb, bitter, cold, heat-clearing and detoxifying, laxative, diuretic, blood-cooling and hemostasis, insecticidal and antipruritic. Treats constipation, stranguria, jaundice, hematemesis, intestinal wind, functional uterine bleeding, alopecia, scabies, carbuncle, traumatic injury. "Southern Yunnan Materia Medica" compilation: Treats all kinds of heat toxins, purges the six internal organs, purges the six meridians, relieves fever due to consumptive tuberculosis, promotes urination, and treats heat.
[0041] Platycodon grandiflorum, bitter, pungent, neutral, enters the lung meridian. Platycodon grandiflorum is pungent, dispersing, bitter, and purgative, neutral in nature, light and floating, good at opening and dispersing lung qi, removing phlegm and relieving sore throat, and also expelling pus. "Compendium of Materia Medica": "It treats dysentery, breaks blood, removes accumulated qi, eliminates accumulation and phlegm, treats lung heat and promotes cough, eliminates cold pain in the abdomen, and treats nausea and convulsions in children."
[0042] Cinnamon twig is pungent, sweet and warm in nature. It enters the heart, lung and bladder meridians. Cinnamon twig is pungent, dispersing, warming and unblocking, sweet and warm to help yang. It warms and unblocks the body, moistens and unblocks the body's yang, and unclogs the blood vessels. It enters the lung and bladder meridians, is good at dispersing wind and cold and relieving wind and cold or wind evil on the surface. It enters the heart meridian and blood, is good at warming and unblocking yang, dispersing cold evil, unblocking blood vessels, unblocking chest yang, warming and transforming water and dampness, and relieving pain. "Famous Doctors' Records" says: "Heartache, flank pain, warm tendons and unblock meridians, stop restlessness and sweating."
[0043] Fenugreek is bitter in taste, warm in nature, and enters the kidney meridian. It is used for kidney yang deficiency, coldness in the lower abdomen, cold pain in the lower abdomen, abdominal pain caused by cold hernia, and beriberi caused by cold and dampness.
[0044] The mechanism of action of the enema solution is that the pressure generated by enema input can cause the fluid in the intestine to move upward, thereby affecting the uterus and surrounding tissues. The drug components in the enema solution can quickly affect the diverticula through the blood circulation, help control local inflammatory responses, and promote healing; through the penetration and absorption of the enema solution, it indirectly supports the healing of the tissues around the uterine incision diverticula; the enema solution can produce a certain mechanical expansion effect through the increase in its liquid volume, prompting the structure within the diverticula to be moderately expanded, which helps to better observe the internal situation of the diverticula and discharge the contents therein.
[0045] The herb is pungent, bitter and warm in nature. It enters the liver and kidney meridians. It has the effects of dispelling wind and dampness, relaxing muscles and activating blood circulation, dispersing blood stasis and reducing swelling, detoxifying and relieving pain. "Shandong Chinese Herbal Medicine Handbook": "It dispels rheumatism, activates blood circulation and relieves pain."
[0046] Asarum is pungent and warm in nature. It enters the heart, lung and kidney meridians. It is good at dispelling wind and cold, opening the orifices and relieving pain. It is a good medicine for treating pain caused by wind-cold, rheumatism, and nasal sinusitis and nasal congestion. "Ben Jing": "It is used to treat cough, headache, brain palpitations, cramps in all joints, rheumatic pain, and dead muscles."
[0047] Smilax glabra, sweet, light, flat in nature. Enters the liver and stomach meridians. Used for damp-heat stranguria, leucorrhea, carbuncle, scrofula, scabies.
[0048] Chuanlianzi is bitter and cold; it enters the liver, stomach, small intestine, and bladder meridians; it can relieve liver heat, promote qi and relieve pain, and treat liver depression and qi stagnation or liver-stomach disharmony, especially for those with heat. "Medical Introduction" says: "It can treat kidney qi injury, bladder and small intestine qi pain. It can also treat internal organ toxins and bleeding."
[0049] Zhui Di Feng tastes sour and astringent, and is warm in nature; it relaxes muscles and tendons, dispels wind and promotes blood circulation.
[0050] Fennel is spicy and warm in nature. It enters the liver, kidney, spleen and stomach meridians. It has the effects of dispelling cold and relieving pain, regulating qi and harmonizing the stomach.
[0051] Linderae radix, pungent, warm. Enters the lung, spleen, kidney, and bladder meridians. Good at promoting qi, dispelling cold, and relieving pain, it can treat pain caused by cold stagnation and qi stagnation in the triple energizer, and is a good product for promoting qi, dispelling cold, and relieving pain. It can also warm the kidney, dispel cold air in the bladder, and treat yang deficiency enuresis and frequent urination.
[0052] Patrinia salsa is pungent, bitter, and slightly cold in nature. It enters the stomach, large intestine, and liver meridians. It is pungent, dispersing, bitter, and purging, slightly cold and can clear away heat. It enters the stomach, large intestine, and liver meridians. It can move qi and enter the blood, clear away heat and detoxify, discharge pus and eliminate carbuncle, and also dispel blood stasis and relieve pain. It can be used for those with heat toxicity and blood stasis, or heat toxicity and blood stasis. It can treat both internal and external carbuncle, and is good at treating internal carbuncle. It mainly treats abdominal pain caused by intestinal carbuncle, and can also treat liver carbuncle, lung carbuncle, and chest and abdominal pain caused by blood stasis. "Famous Doctors' Records": "It can eliminate carbuncle, edema, heat accumulation, rheumatism, and abdominal pain after childbirth." "New Materia Medica": "It can detoxify and discharge pus, treat carbuncle, break blood clots, and treat various postpartum diseases."
[0053] Goldenrod, warm in nature, slightly pungent in taste. Expel wind, activate blood circulation, detoxify. Treat rheumatism, back and leg pain, traumatic injury, scrofula. It is the rhizome of the plant Smilax glabra of the Liliaceae family. Liver meridian; kidney meridian. "Pin Hui Jing Yao": Dissipate swelling and poison. "Compendium of Materia Medica": Treat thirst, metrorrhagia, diarrhea.
[0054] Litchi kernel has the effects of promoting qi and dispersing stagnation, dispelling cold and relieving pain. It is used to treat hernia pain. It mainly enters the liver meridian, has a pungent taste that can promote qi and bitter taste that can relieve pain, and has the effects of pungent and warming to dispel cold, so it has the effects of soothing the liver and regulating qi, promoting qi and dispersing stagnation, dispelling cold and relieving pain.
[0055] Red peony root, red peony root is bitter and slightly cold. It enters the liver meridian. Red peony root is bitter and can dissipate, slightly cold and can clear, specifically enters the liver meridian, cools and disperses blood stasis. It can clear liver fire and cool blood, and promote blood circulation and remove blood stasis. It combines cooling blood heat, clearing liver fire, and dispersing blood stasis. It can be used for blood heat, blood stasis, liver fire, whether single or concurrent, especially for pain caused by blood heat and blood stasis, blood stasis and heat, or liver fire and blood stasis. "Southern Yunnan Materia Medica": "It can relieve spleen fire, lower qi, promote blood circulation, break blood stasis, disperse blood clots, stop abdominal pain, reduce blood heat, attack carbuncle, and treat scabies.
[0056] Ligusticum chuanxiong is pungent and warm in nature. It enters the liver, gallbladder and pericardium meridians. Ligusticum chuanxiong is pungent and fragrant, dispersing, warming and unblocking. It enters the liver, gallbladder and pericardium meridians. It goes up to the head and down to the blood sea, promoting blood and qi inside and dispersing wind and cold outside. It has strong blood-activating ability and is suitable for treating various pains caused by blood stasis and qi stagnation, and is most suitable for those with combined cold. It was praised by predecessors as "the qi medicine in the blood". It is the best medicine for treating many types of headaches, and is best for those with wind-cold and blood stasis. It can also be used for those with wind-heat, rheumatism and blood deficiency. Therefore, predecessors said that "Ligusticum chuanxiong is indispensable for headaches". "Compendium of Materia Medica·Volume 14": "It is a qi medicine in the blood. The liver is bitter and urgent, so it is supplemented with pungent, so it is suitable for those with blood deficiency; pungent to disperse it, so it is suitable for those with qi depression."
[0057] The mechanism of action of the ginger therapy bag is that through the stimulation of ginger therapy, different preparations of drugs are applied to the skin, orifices, acupuncture points and other parts. The external application of external drugs is close to the skin, and the smell of the drugs passes through the skin to reach the meridians directly to regulate the qi, blood, yin and yang, and to strengthen the body and eliminate evil. After local external application, the drug directly enters the part to take effect and promote blood circulation. It enters the local skin through penetration, changes the local blood circulation, can relieve pain, and promote the absorption of inflammation.
[0058] Dried ginger is pungent and hot in nature. It enters the spleen, stomach, kidney, heart, and lung meridians. It can dispel the cold evil of the spleen and stomach and help the yang of the spleen and stomach. It is an important medicine for warming the middle and dispelling cold. It is suitable for both real cold and virtual cold syndromes to enter the heart meridian, can restore yang and unblock the meridians, and is often used in conjunction with aconite to restore yang and rescue the adverse, and treat yang loss and impending collapse.
[0059] Qiannianjian, pungent, warm. Enters the liver and lung meridians. "New Reference for Medicinal Pieces": Enters the blood, dispels rheumatic pain, strengthens tendons and bones, and treats joint pain.
[0060] Qianghuo, pungent, bitter, warm. Enter the bladder and kidney meridians. Pungent, dispersing, bitter, dry, warm, ascending, and strong. It has the effects of dispelling cold, dispelling wind and dampness, and relieving pain.
[0061] Duhuo, pungent, bitter, slightly warm. Enter the kidney and bladder meridians. Pungent, dispersing, bitter, dry, slightly warm and can clear the meridians.
[0062] Zanthoxylum bungeanum is spicy and warm in nature. It enters the spleen, stomach and kidney meridians. It can be used for symptoms such as external cold invading the inside, stomach cold abdominal pain, vomiting, etc.
[0063] Angelica dahurica is pungent and warm in nature. It enters the stomach, large intestine, and lung meridians. It is pungent, warm, and dry, and aromatic and invigorating. It is good at dispersing wind and cold, removing dampness, and opening the nasal orifices and joints. It is also good at relieving pain, relieving phlegm, and stopping leukorrhea. It can also dissipate lumps and promote the discharge of pus.
[0064] Radix Aconiti Kusnezoffii is pungent, bitter and hot in nature. It enters the heart, liver, kidney and spleen meridians. According to the Ben Jing, it is used to treat stroke, wind aversion, sweating, cold and dampness, cough and reverse breathing, and to break up the accumulation of cold and heat.
[0065] Artemisia argyi is pungent, bitter and warm in nature and enters the liver, spleen and kidney meridians. It is pungent, bitter, dry, warm and dispersing in nature. It is warm when raw and hot when cooked. It is also astringent when fried. It can be used externally for fumigation and washing, and can dry out dampness, kill insects and relieve itching. Moxibustion can warm and dredge the meridians, dispel cold and relieve pain or swelling.
[0066] Borneol can invigorate the mind, clear away heat and relieve pain, prevent corruption and promote tissue regeneration, open all orifices, reduce swelling and disperse stagnation.
[0067] Goose does not eat grass, the medicinal property is pungent and warm. It enters the lung meridian. "Shengcao Xing Beiyao" says: "It can relieve depression, remove cold, stop malaria and stop dysentery.
[0068] Compared with the prior art, the present invention has the following beneficial effects:
[0069] (1) The Chinese medicine composition prescription for treating uterine incisional diverticulum of the present invention has the effects of dispersing evil spirits, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and regulating qi and blood. It is used to treat diseases such as prolonged menstruation, secondary infertility, chronic pelvic pain, chronic abdominal pain, etc. caused by uterine incisional diverticulum, and achieves good results.
[0070] (2) The radix bupleuri of the present invention dispels pathogenic qi in the gallbladder meridian and relieves fever, the white peony root nourishes blood and regulates menstruation, astringes yin and stops sweating, the codonopsis root produces body fluid and nourishes blood, the stir-fried atractylodes macrocephala treats water retention, promotes urination, and eliminates restlessness and muscle atrophy, the astragalus root supports sores and promotes diuresis and swelling, and treats qi and blood deficiency, the pollen of radix trichosanthis dispels lumps and ulcers and promotes the discharge of pus, the rhubarb has a laxative effect and promotes diuresis, the platycodon is good at opening and dispersing lung qi, removing phlegm and relieving sore throat, and also discharges pus, the cinnamon twig dispels cold pathogenic qi, dredges blood vessels, warms and transforms dampness, and relieves pain, the fenugreek is used for lower abdominal cold pain and abdominal pain caused by cold hernia, the rhizoma spatholobi dispels wind and dredges the collaterals, promotes diuresis and relieves numbness, the herb spatholobi relaxes the muscles and dredges the collaterals, activates blood circulation and reduces swelling, the millettia spatholobi activates blood circulation and dredges the collaterals, relieves pain and nourishes blood, the honeysuckle vine clears heat and detoxifies, dispels wind and dredges the collaterals, and the blood clotting agent breaks up blood stasis, relieves pain, and promotes tissue regeneration. The whole prescription plays the role of dispersing pathogenic qi, promoting blood circulation and removing blood stasis, clearing heat and detoxifying, and regulating qi and blood.
[0071] (3) The present invention first soaks rhubarb, platycodon, blood clovers and fenugreek before extraction, which helps the medicinal materials absorb water and softens their structure, thereby promoting the release of effective ingredients; at the same time, bupleurum, rhizoma lucidum and astragalus are cut into segments and then mixed with stir-fried atractylodes, root of trichosanthes, honeysuckle, cinnamon twig and herba schizonepetae and boiled together, which not only increases the surface area of bupleurum, rhizoma lucidum and astragalus, which is conducive to the release of ingredients, but also can be boiled together with stir-fried atractylodes, root of trichosanthes, honeysuckle, cinnamon twig and herba schizonepetae, which can largely not affect the synergistic effects of the medicinal materials in clearing heat and toxins, relieving liver depression and harmonizing internal organs, and has a better effect in treating infection and inflammation.
[0072] (4) The present invention combines oral medication with enema solution and ginger therapy bag. First, the direct oral medication has strong efficacy. After oral administration, the enema solution prepared by the present invention is used for enema. The pressure generated by the enema input can prompt the liquid in the intestine to move upward, thereby affecting the uterus and surrounding tissues. The drug components in the enema solution can quickly affect the diverticula through blood circulation, help control local inflammatory reactions, and promote healing; at the same time, the enema solution can produce a certain mechanical expansion effect through the increase in its liquid volume, prompting the structure in the diverticula to be moderately expanded, which helps to better observe the internal situation of the diverticula and discharge the contents therein; at the same time, the ginger therapy bag acts on the lower abdomen, and the stimulating effect of ginger therapy makes it easier for the drug to penetrate the skin of the lower abdomen through the smell, thereby promoting blood circulation and relieving pain; through oral administration, ginger therapy, and enema, the lesions are synergistically acted on in multiple dimensions, and it is used to treat uterine incision diverticula, shortening menstruation, having good analgesic effect, and taking effect quickly. DETAILED DESCRIPTION
[0073] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the embodiments. Of course, the specific embodiments described here are only used to explain the present invention and are not used to limit the present invention.
[0074] Although the steps in the present invention are arranged with numbers, they are not used to limit the order of the steps. Unless the order of the steps is clearly stated or the execution of a certain step requires other steps as a basis, the relative order of the steps can be adjusted. It is understood that the term "and / or" used in this article involves and covers any and all possible combinations of one or more of the associated listed items.
[0075] Unless otherwise specified, the chemical reagents and materials in the present invention are purchased from commercial sources or synthesized from raw materials purchased from commercial sources.
[0076] Example 1
[0077] A Chinese medicine composition for treating uterine incisional diverticulum, the Chinese medicine composition comprising an oral medicine, an enema solution and a ginger treatment bag, wherein the oral medicine is prepared from the following raw materials in parts by weight:
[0078] 10 parts of Herba Lycopodii, 15 parts of Radix Paeoniae Alba, 12 parts of Radix Bupleuri, 15 parts of Fructus Liquidambar, 15 parts of Caulis Millettiae, 15 parts of Codonopsis Pilosulae, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Radix Astragali, 15 parts of Radix Trichosanthis, 10 parts of Rheum Officinale, 10 parts of Platycodon Grandiflorum, 15 parts of Caulis Lonicerae, 1-5 parts of Sanguisorba Officinalis, 10 parts of Cinnamomum cassia, and 10 parts of Fenugreek;
[0079] The enema solution is made of the following raw materials in parts by weight:
[0080] 10 parts of cinnamon twig, 10 parts of radix scutellariae, 10 parts of asarum, 15 parts of rhizoma smilacis, 10 parts of fructus toosendan, 10 parts of radix bupleuri, 10 parts of herba schizonepetae, 10 parts of fennel, 10 parts of lindera, 15 parts of herba patriniae, 15 parts of scutellariae, 15 parts of rhizoma liquidambar formosanae, 15 parts of semen litchi, 15 parts of herba rubrae, and 10 parts of rhizoma ligustici;
[0081] The ginger therapy bag is made of the following raw materials in parts by weight:
[0082] 15 parts of dried ginger, 10 parts of Rhizoma Anemarrhenae, 10 parts of Herba Lycopodii, 10 parts of Rhizoma Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 10 parts of Rhizoma Aconiti Kusnezoffii, 10 parts of Herba Lycopodii, 10 parts of Folium Artemisiae Argyi, 10 parts of Asarum, 10 parts of Borneolum Syntheticum, 10 parts of Ramulus Cinnamomi, 10 parts of Fructus Cuscutae, and 10 parts of Herba Echinops.
[0083] The preparation method of the oral medicine comprises the following steps:
[0084] Step 1: Weigh rhubarb, platycodon, dragon's blood, and fenugreek in proportion, first add 7 times the amount of water to soak for 2.5 hours, and then decoct for 1.5 hours at a decoction temperature of 90°C. After decoction, filter to obtain filtrate 1;
[0085] Step 2: Weigh Bupleurum, Smilax glabra and Astragalus according to the proportion, cut into 2 cm segments and set aside;
[0086] Step 3: Weigh stir-fried Atractylodes macrocephala, Radix Trichosanthis, Caulis Lonicerae, Cinnamomum cassiae and Herba Lycopodiellae according to proportion, and mix together with Radix Bupleuri, Fructus Smilacis Glabrae and Radix Astragali cut in step 2, add 7 times amount of water and boil for 2.5 hours at 90° C., filter after boiling to obtain filtrate 2;
[0087] Step 4: Mix filtrate 1 and filtrate 2 evenly and fill the mixture.
[0088] The preparation method of the enema liquid comprises the following steps: weighing various Chinese medicines in proportion, mixing and crushing them, adding water to soak for half an hour, and then boiling twice, each time for 1.3 hours, combining the decoctions and placing them in a vacuum concentration tank to concentrate them to a relative density of 1.07 (60° C.), standing for 24 hours, taking the supernatant and filtering it, and filling the filtrate to obtain the enema liquid.
[0089] The preparation method of the ginger therapy bag comprises the following steps: firstly, putting dry ginger into a pot and frying it to 45° C., then weighing other Chinese medicines according to proportion, grinding them into powder and putting them into the pot and stirring them evenly, and then putting them into a non-woven bag after stirring them evenly to make the ginger therapy bag.
[0090] The method of using the oral medicine, enema solution and ginger therapy bag is to first take the oral medicine orally, then lie on one's side, perform enema with the enema solution through enema operation, lie flat after enema, and spread the heated ginger therapy bag flat on the lower abdomen.
[0091] Example 2
[0092] A Chinese medicine composition for treating uterine incisional diverticulum, the Chinese medicine composition comprising an oral medicine, an enema solution and a ginger treatment bag, wherein the oral medicine is prepared from the following raw materials in parts by weight:
[0093] 8 parts of Herba Lycopodii, 12 parts of Radix Paeoniae Alba, 8 parts of Radix Bupleuri, 12 parts of Fructus Liquidambar, 12 parts of Caulis Millettiae, 12 parts of Codonopsis Pilosulae, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Radix Astragali, 12 parts of Radix Trichosanthis, 8 parts of Rheum Officinale, 8 parts of Platycodon Grandiflorum, 12 parts of Caulis Lonicerae, 1 part of Sanguisorba Officinalis, 8 parts of Cinnamomum cassia, and 8 parts of Fenugreek;
[0094] The enema solution is made of the following raw materials in parts by weight:
[0095] 8 parts of cinnamon twig, 8 parts of radix scutellariae, 8 parts of asarum, 12 parts of rhizoma smilacis, 8 parts of fructus toosendan, 8 parts of radix bupleuri, 8 parts of herba schizonepetae, 8 parts of fennel, 8 parts of lindera, 12 parts of herba patriniae, 12 parts of scutellariae, 12 parts of rhizoma liquidambar formosanae, 12 parts of semen litchi, 12 parts of herba rubrae, 8 parts of rhizoma ligustici;
[0096] The ginger therapy bag is made of the following raw materials in parts by weight:
[0097] 12 parts of dried ginger, 8 parts of Rhizoma Cibotii, 8 parts of Herba Angelicae Pubescentis, 8 parts of Rhizoma Angelicae Dahuricae, 8 parts of Rhizoma Chuanxiong, 8 parts of Rhizoma Aconiti Kusnezoffii, 8 parts of Herba Lycopodii, 8 parts of Folium Artemisiae Argyi, 8 parts of Herba Asari, 8 parts of Borneolum Syntheticum, 8 parts of Ramulus Cinnamomi, 8 parts of Fructus Foeniculi, 8 parts of Herba Cuscutae, 8 parts of Herba Echinops.
[0098] The preparation method of the oral medicine comprises the following steps:
[0099] Step 1: Weigh rhubarb, platycodon, dragon's blood, and fenugreek in proportion, first add 6 times the amount of water to soak for 2 hours, and then decoct for 1 hour at a decoction temperature of 80°C. After decoction, filter to obtain filtrate 1;
[0100] Step 2: Weigh Bupleurum, Smilax glabra and Astragalus according to the proportion, cut into 1 cm segments and set aside;
[0101] Step 3: Weigh stir-fried Atractylodes macrocephala, Radix Trichosanthis, Caulis Lonicerae, Cinnamomum cassiae and Herba Lycopodiellae according to proportion, and mix together with Radix Bupleuri, Fructus Smilacis Glabrae and Radix Astragali cut in step 2, add 6 times amount of water and boil for 2 hours at 80° C. After boiling, filter to obtain filtrate 2;
[0102] Step 4: Mix filtrate 1 and filtrate 2 evenly and fill the mixture.
[0103] The preparation method of the enema liquid comprises the following steps: weighing various Chinese medicines in proportion, mixing and crushing them, adding water to soak for half an hour, and then boiling them twice, each time for 1 hour, combining the decoctions and putting them into a vacuum concentration tank to concentrate them to a relative density of 1.06 (60° C.), standing for 24 hours, taking the supernatant and filtering it, and filling the filtrate to obtain the enema liquid.
[0104] The preparation method of the ginger therapy bag comprises the following steps: firstly, putting dry ginger into a pot and frying it to 40° C., then weighing other Chinese medicines in proportion, grinding them into powder and putting them into the pot and stirring them evenly, and then putting them into a non-woven bag after stirring them evenly to make the ginger therapy bag.
[0105] The method of using the oral medicine, enema solution and ginger therapy bag is to first take the oral medicine orally, then lie on one's side, perform enema with the enema solution through enema operation, lie flat after enema, and spread the heated ginger therapy bag flat on the lower abdomen.
[0106] Example 3
[0107] A Chinese medicine composition for treating uterine incisional diverticulum, the Chinese medicine composition comprising an oral medicine, an enema solution and a ginger treatment bag, wherein the oral medicine is prepared from the following raw materials in parts by weight:
[0108] 12 parts of Herba Lycopodii, 18 parts of Radix Paeoniae Alba, 15 parts of Radix Bupleuri, 18 parts of Fructus Liquidambar, 18 parts of Caulis Millettiae, 18 parts of Codonopsis Pilosulae, 18 parts of Rhizoma Atractylodis Macrocephalae, 18 parts of Radix Astragali, 18 parts of Radix Trichosanthis, 12 parts of Rheum Officinale, 12 parts of Platycodon Grandiflorum, 18 parts of Caulis Lonicerae, 5 parts of Sanguisorba Officinalis, 12 parts of Cinnamomum cassia, and 12 parts of Fenugreek;
[0109] The enema solution is made of the following raw materials in parts by weight:
[0110] 12 parts of cinnamon twig, 12 parts of radix scutellariae, 12 parts of asarum, 18 parts of rhizoma smilacis, 12 parts of fructus toosendan, 12 parts of radix bupleuri, 12 parts of herba schizonepetae, 12 parts of fennel, 12 parts of lindera, 18 parts of herba patriniae, 18 parts of scutellariae, 18 parts of rhizoma liquidambar formosanae, 18 parts of semen litchi, 18 parts of herba rubrae, 12 parts of rhizoma ligustici;
[0111] The ginger therapy bag is made of the following raw materials in parts by weight:
[0112] 18 parts of dried ginger, 12 parts of Rhizoma Anemarrhenae, 12 parts of Herba Angelicae Pubescentis, 12 parts of Rhizoma Angelicae Dahuricae, 12 parts of Rhizoma Chuanxiong, 12 parts of Rhizoma Aconiti Kusnezoffii, 12 parts of Herba Lycopodii, 12 parts of Folium Artemisiae Argyi, 12 parts of Herba Asari, 12 parts of Borneolum Syntheticum, 12 parts of Ramulus Cinnamomi, 12 parts of Fructus Cuscutae, and 12 parts of Herba Echinops.
[0113] The preparation method of the oral medicine comprises the following steps:
[0114] Step 1: Weigh rhubarb, platycodon, dragon's blood, and fenugreek in proportion, first add 8 times the amount of water to soak for 3 hours, and then decoct for 2 hours at a decoction temperature of 100° C. After decoction, filter to obtain filtrate 1;
[0115] Step 2: Weigh Bupleurum, Smilax glabra and Astragalus according to the proportion, cut into 3 cm segments and set aside;
[0116] Step 3: Weigh stir-fried Atractylodes macrocephala, Radix Trichosanthis, Caulis Loniceraes, Cinnamomum cassiae and Herba Lycopodiellae according to proportion, and mix together with Radix Bupleuri, Fructus Smilacis Glabrae and Radix Astragali cut in step 2, add 8 times amount of water and boil for 3 hours at a boiling temperature of 100° C. After boiling, filter to obtain filtrate 2;
[0117] Step 4: Mix filtrate 1 and filtrate 2 evenly and fill the mixture.
[0118] The preparation method of the enema liquid comprises the following steps: weighing various Chinese medicines in proportion, mixing and crushing them, adding water to soak for half an hour, and then boiling twice, each time for 1.5 hours, combining the decoctions and placing them in a vacuum concentration tank to concentrate them to a relative density of 1.08 (60° C.), standing for 24 hours, taking the supernatant and filtering it, and filling the filtrate to obtain the enema liquid.
[0119] The preparation method of the ginger therapy bag comprises the following steps: firstly, putting dry ginger into a pot and frying it to 50° C., then weighing other Chinese medicines according to proportion, grinding them into powder and putting them into the pot and stirring them evenly, and then putting them into a non-woven bag after stirring them evenly to make the ginger therapy bag.
[0120] The method of using the oral medicine, enema solution and ginger therapy bag is to first take the oral medicine orally, then lie on one's side, perform enema with the enema solution through enema operation, lie flat after enema, and spread the heated ginger therapy bag flat on the lower abdomen.
[0121] Experimental effect part:
[0122] Basic information: A total of 120 patients aged 20 to 45 years who met the diagnostic criteria for uterine incisional diverticulum were clinically observed in the Department of Traditional Chinese Medicine of Hubei Provincial Maternity and Child Health Hospital from March 15, 2021 to March 15, 2024.
[0123] Diagnostic criteria:
[0124] (1) Western medicine diagnostic criteria: formulated with reference to the "Guidelines for the Diagnosis and Treatment of Abnormal Uterine Bleeding". ① A history of one or more lower segment cesarean sections; ② Abnormal vaginal bleeding with symptoms of prolonged menstruation (menstrual period greater than 7 days) and menstrual bleeding, and other diseases causing these symptoms have been excluded, with a course of more than 2 months; ③ Vaginal three-dimensional color Doppler ultrasound indicates uterine incision diverticulum, with thinning and discontinuity of the residual myometrium at the lower segment of the anterior uterine wall where the cesarean section was made, defects or fissures in the myometrium communicating with the uterine cavity, and no echo or low no echo, with an intact serosal layer and interrupted endometrial line.
[0125] (2) TCM diagnostic criteria: formulated based on the relevant criteria for prolonged menstruation and blood stasis syndrome in the "Guidelines for Clinical Research of New Chinese Medicines". ① Main symptoms: basically normal menstrual cycle and menstrual volume, menstruation lasting more than 7 days, for more than 2 consecutive menstrual cycles. ② Secondary symptoms: ① dark purple lips, gums, and nails; ② dark purple menstrual blood with blood clots; ③ pain in the lower abdomen or lower abdomen during menstruation; ④ shortness of breath or fatigue; ⑤ tongue and pulse: dark purple tongue or with petechiae and ecchymosis, deep, stringy and thin pulse. The above main symptoms must be present, and any 2 or 4 of the secondary symptoms can be present, combined with the tongue and pulse to make the diagnosis.
[0126] Inclusion criteria: 1. Meet the above diagnostic criteria; 2. Tolerate enema and ginger therapy; 3. Cooperate with relevant investigations and treatments.
[0127] Exclusion criteria: ① Those with other organic lesions in the reproductive system confirmed or suspected by B-ultrasound or other examinations; ② Combined diseases of the internal medical system such as the heart, liver, kidney, blood, and immune system; ③ Allergic to the study drugs and contraindications to taking the above drugs; ④ Failure to use the drugs as prescribed; ⑤ Pregnant or suspected pregnant or lactating women.
[0128] Case selection: From March 15, 2021 to March 15, 2024, the Department of Traditional Chinese Medicine of Hubei Provincial Maternity and Child Health Hospital observed 120 patients who met the diagnostic criteria for pelvic inflammatory disease. The patients were divided into 4 groups, namely Group A, Group B, Group C, and Group D, with 30 cases in each group. After treatment from the 1st to the 21st day of menstruation, no obvious abnormal reactions or other side effects were observed in the patients during the treatment.
[0129] Dosage regimen:
[0130] Group A was the control group 1, which was given Mafulong orally, and took it continuously from the 1st to the 21st day of menstruation, one tablet per day, and 3 menstrual cycles constituted a course of treatment.
[0131] Group B is the control group 2, which is treated with the Chinese medicine composition of Example 1 of the present invention plus ginger therapy: once a day until the 15th day of menstruation, and 3 menstrual cycles constitute one course of treatment.
[0132] Group C is the control group 3, which is treated with the Chinese medicine composition of Example 1 of the present invention for oral administration + enema: once a day until the 15th day of menstruation, and 3 menstrual cycles constitute one course of treatment.
[0133] Group D is the observation group, which takes the Chinese medicine composition of Example 1 of the present invention orally + ginger therapy + enema: once a day until the 15th day of menstruation, and 3 menstrual cycles constitute one course of treatment.
[0134] Contraindications and precautions: Do not use during menstruation or pregnancy. Do not use in patients with severe internal diseases or mental illnesses, or patients who cannot tolerate topical medications. Use with caution in patients who are allergic to medications. Pay attention to the temperature to avoid burns.
[0135] Efficacy observation: One month after the end of the treatment and four months after stopping the medication, the number of days of action were recorded respectively; the change in the size of the uterine diverticulum was examined by B-ultrasound before and after treatment; it was completed within 3 to 7 days after the end of menstruation.
[0136] Treatment effect determination, efficacy evaluation indicators:
[0137] Recovery: The uterine incision has a linear strong echo, and the menstrual period is less than or equal to 7 days;
[0138] Markedly effective: The depth and / or width of the uterine diverticulum is reduced by more than 2 / 3 compared with before treatment, and the menstrual period is 8 to 9 days;
[0139] Effective: The depth and / or width of the uterine diverticulum is reduced by 1 / 3 to 2 / 3 compared with before treatment, and the menstrual period is greater than or equal to 9 days and shortened by greater than or equal to 2 days;
[0140] Ineffective: The depth and / or width of the uterine diverticulum is reduced by 1 / 3 or less compared with before treatment or remains unchanged, and the menstrual period is shortened by less than 2 days compared with before treatment or remains unchanged.
[0141] Treatment effect: After treatment, the menstrual time, uterine diverticulum size and overall efficacy of the patients before and after treatment are compared as shown in Tables 1 to 3:
[0142] Table 1 Comparison of menstrual time before and after treatment
[0143] Group Before treatment 1 month after treatment 4 months after treatment Control group 1 13.56±1.14 10.26±1.08 11.15±1.54 Control group 2 13.26±1.23 8.38±1.28 8.21±1.17 Control group 3 13.45±1.09 8.26±1.12 8.14±1.03 Observation Group 13.61±1.21 7.48±1.31 7.39±1.18
[0144] Table 2 Comparison of uterine diverticulum size before and after treatment
[0145]
[0146]
[0147] Table 3 Comparison of overall efficacy
[0148] years get well Significant effect efficient invalid Total Effectiveness Control group 1 0 1 20 9 70.00% Control group 2 0 7 18 5 83.33% Control group 3 0 7 19 4 86.67% Observation Group 0 9 19 2 93.33%
[0149] According to the results of the efficacy evaluation of the clinical observation cases of patients, the total effective rate of the observation group D of the present invention is 93.33%, and no obvious adverse reactions are observed. The Chinese medicine composition prescription for treating uterine incision diverticulum of the present invention has the effects of dispersing evil spirits, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and regulating qi and blood, and has achieved good results in the problems of prolonged menstruation and the size of uterine diverticulum. The total effective rates of the control group 2 of group B and the control group 3 of group C were 83.33% and 86.67% respectively, which were significantly better than the control group 1 of group A, but less than the observation group of group D of the present invention, and the group D of the present invention was effective quickly.
[0150] The Chinese medicine composition prescription for treating uterine incisional diverticulum of the present invention has the effects of dispersing evil spirits, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and regulating qi and blood. It is used to treat diseases such as prolonged menstruation, secondary infertility, chronic pelvic pain, chronic abdominal pain, etc. caused by uterine incisional diverticulum, and achieves good results. The present invention combines oral drugs with enema liquid and ginger therapy bag. First, direct oral drug efficacy is strong. After oral administration, enema is performed with the enema liquid prepared by the present invention. The pressure generated by enema input can prompt the liquid in the intestine to move upward, thereby affecting the uterus and surrounding tissues. The drug components in the enema liquid can quickly affect the diverticula through blood circulation, help control local inflammatory reactions, and promote healing; at the same time, the enema liquid can produce a certain mechanical expansion effect through the increase in its liquid volume, prompting the structure in the diverticula to be moderately expanded, which is helpful to better observe the internal situation of the diverticula and discharge the contents therein; at the same time, the ginger therapy bag acts on the lower abdomen, and the stimulating effect of ginger therapy makes it easier for the drug to penetrate the skin of the lower abdomen through the smell, thereby promoting blood circulation and relieving pain; oral administration, ginger therapy, and enema act synergistically on the lesion in multiple dimensions, and it is used for the treatment of uterine incision diverticula to shorten menstruation, have good analgesic effect, and take effect quickly.
[0151] The above is only a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements and changes without departing from the creative concept of the present invention, which all belong to the protection scope of the present invention.
Claims
1. A Chinese medicine composition for treating uterine incisional diverticulum, characterized in that: The Chinese medicine composition comprises an oral medicine, an enema solution and a ginger therapy bag, wherein the oral medicine is made of the following raw materials in parts by weight: 8-12 parts of Herba Lycopodii, 12-18 parts of Radix Paeoniae Alba, 8-15 parts of Radix Bupleuri, 12-18 parts of Fructus Lycopodii, 12-18 parts of Caulis Millettiae, 12-18 parts of Codonopsis Pilosulae, 12-18 parts of Rhizoma Atractylodis Macrocephalae, 12-18 parts of Radix Astragali, 12-18 parts of Radix Trichosanthis, 8-12 parts of Rheum Officinale, 8-12 parts of Platycodon Grandiflorum, 12-18 parts of Caulis Honeysuckle, 1-5 parts of Sanguisorba Officinalis, 8-12 parts of Cinnamomum cassia, and 8-12 parts of Fenugreek; The enema solution is made of the following raw materials in parts by weight: 8-12 parts of cinnamon twig, 8-12 parts of radix scutellariae, 8-12 parts of asarum, 12-18 parts of rhizoma smilacis, 8-12 parts of fructus toosendan, 8-12 parts of radix bupleuri, 8-12 parts of herba schizonepetae, 8-12 parts of fennel, 8-12 parts of lindera, 12-18 parts of herba patriniae, 12-18 parts of scutellariae, 12-18 parts of rhizoma lychees, 12-18 parts of herba rubrae, 8-12 parts of rhizoma ligustici; The ginger therapy bag is made of the following raw materials in parts by weight: 12-18 parts of dried ginger, 8-12 parts of Qiannianjian, 8-12 parts of Zhuidifeng, 8-12 parts of Qianghuo, 8-12 parts of Duhuo, 8-12 parts of Zanthoxylum, 8-12 parts of Angelica dahurica, 8-12 parts of Chuanxiong, 8-12 parts of Aconitum, 8-12 parts of Lycopodiella cuneata, 8-12 parts of Artemisia argyi, 8-12 parts of Asarum, 8-12 parts of Borneolum, 8-12 parts of Cassia twig, 8-12 parts of fennel, and 8-12 parts of Escherichia corydalis.
2. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The oral medicine is made of the following raw materials in parts by weight: 10 parts of Herba Lycopodii, 15 parts of Radix Paeoniae Alba, 12 parts of Radix Bupleuri, 15 parts of Fructus Liquidambar, 15 parts of Caulis Millettiae, 15 parts of Codonopsis Pilosulae, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Radix Astragali, 15 parts of Radix Trichosanthis, 10 parts of Rheum Officinale, 10 parts of Platycodon Grandiflorum, 15 parts of Caulis Lonicerae, 1-5 parts of Sanguisorba Officinalis, 10 parts of Cinnamomum cassia, and 10 parts of Fenugreek.
3. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The enema solution is made of the following raw materials in parts by weight: 10 parts of cinnamon twig, 10 parts of herba schizonepetae, 10 parts of asarum, 15 parts of rhizoma smilacis, 10 parts of fructus toosendan, 10 parts of radix bupleuri, 10 parts of herba schizonepetae, 10 parts of fennel, 10 parts of linderae, 15 parts of herba patriniae, 15 parts of scutellariae, 15 parts of rhizoma liquidambar formosanae, 15 parts of semen litchi, 15 parts of herba red peony roots, and 10 parts of rhizoma ligustici.
4. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The ginger therapy bag is made of the following raw materials in parts by weight: 15 parts of dried ginger, 10 parts of Rhizoma Anemarrhenae, 10 parts of Herba Lycopodii, 10 parts of Rhizoma Angelicae Dahuricae, 10 parts of Rhizoma Chuanxiong, 10 parts of Rhizoma Aconiti Kusnezoffii, 10 parts of Herba Lycopodii, 10 parts of Folium Artemisiae Argyi, 10 parts of Asarum, 10 parts of Borneolum Syntheticum, 10 parts of Ramulus Cinnamomi, 10 parts of Fructus Cuscutae, and 10 parts of Herba Echinops.
5. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The preparation method of the oral medicine comprises the following steps: Step 1: Weigh rhubarb, platycodon, dragon's blood, and fenugreek in proportion, first add 6 to 8 times the amount of water to soak for 2 to 3 hours, and then decoct for 1 to 2 hours at a decoction temperature of 80 to 100° C. After decoction, filter to obtain filtrate 1; Step 2: Weigh Bupleurum, Smilax glabra and Astragalus according to the proportion, cut into 1-3 cm segments and set aside; Step 3: Weigh stir-fried Atractylodes macrocephala, Radix Trichosanthis, Caulis Loniceraes, Cinnamomum cassiae and Herba Lycopodiellae according to proportion, and mix together with Radix Bupleuri, Fructus Smilacis Glabrae and Radix Astragali cut in step 2, add 6 to 8 times amount of water and boil for 2 to 3 hours at a boiling temperature of 80 to 100° C. After boiling, filter to obtain filtrate 2; Step 4: Mix filtrate 1 and filtrate 2 evenly and fill the mixture.
6. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The preparation method of the enema liquid comprises the following steps: weighing various Chinese medicines in proportion, mixing and crushing them, soaking them in water for half an hour, and then boiling them twice, each time for 1 to 1.5 hours, combining the decoctions and placing them in a vacuum concentration tank to concentrate them to a relative density of 1.06 to 1.08 (60° C.), standing them for 24 hours, taking the supernatant and filtering them, and filling the filtrate to obtain the enema liquid.
7. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The preparation method of the ginger therapy bag comprises the following steps: firstly, putting dry ginger into a pot and frying it to 40-50° C., then weighing other Chinese medicines according to proportion, grinding them into powder, putting them into the pot and stirring them evenly, and then putting them into a non-woven bag after stirring them evenly to make the ginger therapy bag.
8. A Chinese medicine composition for treating uterine incisional diverticulum according to claim 1, characterized in that: The method of using the oral medicine, enema solution and ginger therapy bag is to first take the oral medicine orally, then lie on one's side, perform enema with the enema solution through enema operation, lie flat after enema, and spread the heated ginger therapy bag flat on the lower abdomen.