Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

32 results about "Arthritis therapy" patented technology

Treatment of all arthritic diseases; may be any type of therapy including drug therapy, gene therapy, immunotherapy, surgery, nutrition, rehabilitation or alternative therapies.

Therapeutic Medicine Containing Monoclonal Antibody Against Folate Receptor Beta (Fr-Beta)

An objective of the present invention is to provide a therapeutic agent for treating rheumatoid arthritis, juvenile rheumatoid arthritis, macrophage activation syndrome, septicemia, and FR-β expressing leukemia, which induces apoptosis in activated macrophages and folate receptor beta (FR-β) expressing leukemia cells to specifically destroy these cells. An FR-β monoclonal antibody of the present invention is preferably an IgG-type monoclonal antibody which specifically reacts with a human-type FR-β antigen and is produced from a clone resulting from immunization with an FR-β expressing B300-19 cell. The FR-β monoclonal antibody of the present invention specifically reacts with the FR-β antigen of activated macrophages and FR-β expressing leukemia cells and a therapeutic agent of the present invention contains an FR-β antibody immunotoxin which causes apoptosis in activated macrophages and FR-β expressing leukemia cells, as an active ingredient. Further, suitable administration form for the therapeutic agent of the present invention includes intravenous injection as well as joint injection in the case of therapeutic agents for rheumatoid arthritis and juvenile arthritis.
Owner:TAKAMI MATSUYAMA KAGOSHIMA UNIV +1

Theurapeutic or prophyiactic agent for arthritis

This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a method for inhibiting arthritis or for promoting the growth of articular chondrocyte by activating GC-B; or a method for screening an agent for promoting the growth of articular chondrocyte or an agent capable of treating arthritis using the GC-B activity as an indication.
Owner:KAZUWA NAKAO +1

Method for treating osteoarthritis

A method and composition for treating osteoarthritis with ion-channel regulators is disclosed. The ion-channel regulators are used alone or in combination with other osteoarthritis treatment agents, including but not limited to injectable agents such as viscosupplements and steroids. A composition comprising one or more ion-channel regulator(s) and one or more osteoarthritis treatment agent(s) is also disclosed.
Owner:CALOSYN PHARMA INC

Ultrasonic microbubbles for treating arthritis and use thereof

InactiveCN103006538AOvercome the trouble of repeated injections for a long timeControl joint inflammationEnergy modified materialsGenetic material ingredientsArthritis therapyCell membrane
The invention discloses ultrasonic microbubbles for treating arthritis and a use thereof. The microbubbles contain gene plasmids capable of expressing tumor necrosis factor receptor (TNFR) protein, wherein the gene plasmids are adsorbed to the surface of the microbubbles and / or packaged in the microbubbles; the gene plasmids are expression plasmids; the gene plasmids of the tumor necrosis factor receptor protein contain extracellular domain gene of the tumor necrosis factor receptor (TNFR) or contain gene segment of the protein or peptide fragment, which can be combined with a tumor necrosis factor (TNF); and the gene plasmids express soluble protein or peptide fragment which can prevent the tumor necrosis factor from combining with the tumor necrosis factor receptor on a cell membrane after transfecting the body cells. The ultrasonic microbubbles are not only low in manufacturing cost for greatly relieving the economic burden of the patients and families, but also have breakthrough development in the field of treating anthritis, and can be extensively popularized and used in the field.
Owner:叶琳

Midlay compartmental tibial component

A Midlay component includes a plastic bearing part and a metal tray part. The upper surface of the bearing part is dished in frontal and sagittal planes, to provide a bearing surface, such that in function, the femoral contact point will remain in the central region of the bearing surface. Hence the load-bearing on the plastic bearing part will be above the thickest portion in the central region. The metal tray part features a tray-bottom that enables retention of strong cortical and cancellous portion of a tibia in the treatment of osteoarthritis of a knee joint, and supports the plastic bearing part, with the rim of the metal tray part maintaining the position of the plastic bearing part and minimizing micromotions.
Owner:WEI CHIH SHING +1

Composition comprising stem cell-derived exosome containing culture as effective ingredient for preventing or treating arthritis

The present invention relates to a composition of a stem cell-derived exosome-containing culture for preventing or treating arthritis and, more particularly, to a pharmaceutical composition comprisinga stem cell-derived exosome-containing culture as an effective ingredient for preventing or treating arthritis, wherein the stem cell-derived exosome-containing culture is obtained by treating a stemcell culture with TNF-[alpha] and incubating the stem cell culture in the condition of a 1-8 % oxygen concentration. Containing a large amount of exosomes containing functional effective ingredientssuch as a cartilage regeneration promoting factor, etc., the stem cell-derived exosome-containing culture according to the present invention was found to have a far higher therapeutic effect on arthritis, compared to conventional stem cell transplantation methods for treatment of arthritis and the application of cultures obtained in general stem cell culturing conditions. Hence, the stem cell-derived exosome-containing culture according to the present invention has the effect of being available as a new therapeutic agent for effective treatment of arthritis.
Owner:设计细胞股份有限公司

Human small joint inflammation physiotherapy instrument

InactiveCN107320306AChanging the action of frictionPrevent movementPneumatic massageArthritis therapyTreatment effect
A physiotherapy instrument for human facet joint inflammation, which relates to the technical field of medical treatment equipment, includes a hard treatment cavity and a negative pressure generation control system, and at least one opening for limbs to extend in and out is provided on the treatment cavity, and the The treatment chamber is connected with a negative pressure generation control system through the airway. The treatment chamber is L-shaped, and can be used for limbs to be placed after bending part or all of the thigh with the knee up and the calf with the knee down, and for the elbow to go up. A part of the arm and a part or all of the lower bladder from the elbow are bent and put in; the L-shaped treatment cavity is composed of two parts that cooperate with each other as a whole, and the two components are sealed with sealing strips at the seams; the treatment cavity The opening and the limb are fixed through a sealed connection assembly. The invention is light, easy to operate in and out of the limbs, completely eliminates the radial pressure, and greatly improves the therapeutic effect.
Owner:全成线

Inducing expression of puma to reduce joint inflammation in the treatment of arthritis

InactiveUS20070065421A1Reduced activityBiocidePeptide/protein ingredientsFibroblast-like synoviocyteArthritis therapy
It has been discovered the BH3-only proapoptotic Bcl-2 proteins like PUMA (the p53 upregulated modulator of apoptosis) can be activated in fibroblast-like synoviocytes present in the joints of subjects with rheumatoid arthritis. This bypasses the p53 apoptotic pathway, which normally clears FLS fomr the joints, but is often defective in arthritis. Suitable therapeutic agents of this invention include gene vectors that cause increased expression of BH3-only proapoptotic proteins in target cells. These agents are formulated in pharmaceutical compositions for administration directly to joint. Reestablishing apoptosis in synoviocytes decreases their pro-inflammatory and destrcutive activity, improving the clinical condition.
Owner:RGT UNIV OF CALIFORNIA

Arthritis therapeutic instrument capable of completely adhering joints of different human bodies

The invention discloses an arthritis therapeutic instrument capable of completely adhering joints of different human bodies. The arthritis therapeutic instrument comprises a folding sleeve; magnetic suction plates are vertically arranged at two sides of the folding sleeve; a plurality of fixing blocks are arranged inside the magnetic suction plates at intervals; a sliding ring is arranged in the center of one side, far away from the folding sleeve, of each fixing block; each sliding ring is mutually and rotationally connected with one corresponding fixing block through fixing rods at two sides; and connecting blocks are arranged among the plurality of fixing blocks. According to the invention, surrounding springs are driven to bend, so that one side, close to a diseased joint, of each surrounding spring is compressed, and one side, far away from the diseased joint, of each surrounding spring is expanded; and springs in the connecting blocks are driven to bend, so that the magnetic attraction plates are mutually tensioned. In addition, attachment is kept through pulling force of the surrounding springs, so that the surrounding springs are driven to move when the fixing blocks move;and the rthritis therapeutic instrument has the advantages that the rthritis therapeutic instrument can be mutually attached to the joint, and the position can be adjusted after the rthritis therapeutic instrument is fixed without disassembly.
Owner:李艳梅

Biological agent for treating arthritis as well as preparation method and application of biological agent

The invention relates to a biological agent for treating arthritis as well as a preparation method and application of the biological agent. The biological agent is prepared from urinary stem cell exosome rich in miR40-5p. The urinary stem cell exosome suspension rich in miR40-5p is used for joint cavity injection treatment of a patient suffering from knee osteoarthritis, and meanwhile, the mesenchymal stem cells and the miR40-5p are combined to relieve osteoarthritis progress and promote cartilage regeneration, so that the biological hidden danger during stem cell injection treatment and the poor targeting property of miR40-5p injection treatment are avoided; the injection type biological preparation for treating knee osteoarthritis is a novel injection type biological preparation for treating knee osteoarthritis, which is rich in innovation and clinical conversion value.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Intelligent arthritic therapeutic apparatus

The invention discloses an intelligent arthritic therapeutic apparatus, which comprises a device body and a power supply interface, wherein the exterior of the device body is provided with the power supply interface; the power supply interface is arranged in the device body in an embedment manner; a movable connecting block is provided with an electromagnetic therapeutic apparatus; one end of theelectromagnetic therapeutic apparatus is fixedly connected with the movable connecting block; the electromagnetic therapeutic apparatus is arranged above the movable connecting block; one end of the electromagnetic therapeutic apparatus is fixedly connected with the movable connecting block; the interior of the device body is provided with an infrared therapeutic apparatus; the infrared therapeutic apparatus is fixedly connected onto the device body. The interior of the intelligent arthritic therapeutic apparatus is provided with the movable connecting block; the movable connecting block is movably connected onto the inner wall of the device body; further, the movable connecting block is made from a soft material and the movable connecting block can be used for carrying out movement, and can be fully abutted on a joint of a human body according to a different part of a patient when being used, so that the full treatment is carried out on the patient.
Owner:南宁市第八人民医院

Method for preparing pellets of chondrocytes from human induced pluripotent stem cells, and use thereof

A method for preparing chondrocyte pellets including: (a) culturing human induced pluripotent stem cells so as to form and obtain embryoid bodies; (b) inducing the embryonic bodies obtained in step (a) to become outgrowth cells and isolating same; and (c) culturing the outgrowth cells isolated in step (b) in a pellet form. A pharmaceutical composition including the chondrocyte pellets prepared by the preparation method; or a method for preventing or treating arthritis, including administering the chondrocyte pellets prepared by the method to an arthritis patient. Chondrocyte pellets of the present invention have a remarkably high rate of differentiation into chondrocytes, uniform size, and a homogeneous differentiation degree, and a pharmaceutical composition, including the pellets, has excellent cartilage regeneration effects at the site of cartilage damage, and is in injectable form, which does not require surgery, such that pain is relieved and a continuous arthritis treatment is provided.
Owner:YIPCELL INC

Therapeutic agent for arthritis

The present invention provides with a therapeutic agent for arthritis, which contains a low-molecular-weight FoxM1 inhibitor, e.g., thiostrepton, as an active ingredient. FoxM1 is expressed in an osteoclast progenitor that occurs specifically in an inflamed synovium in arthritis, and is not involved in the function of an osteoclast that is present in the bone marrow in a normal person and is involved in normal bone metabolism. Therefore, arthritis can be prevented and / or treated without any adverse side effect by using a FozM1 inhibitor.
Owner:OSAKA UNIV

Arthritis physiotherapy device beneficial to full absorption of liquid medicines on surface

The invention relates to the technical field of arthritis treatment equipment, and discloses an arthritis physiotherapy device beneficial to full absorption of liquid medicines on surface. The devicecomprises a sleeve, the lower end of a rotary drum is connected to a first rectangular magnetic block, the inner side of the upper end of the rotary drum is connected to a U-shaped magnet, a piston isconnected into a medicine conveying device, the lower end of the piston is connected to a U-shaped rod, the outer end of the U-shaped rod is connected to a transverse plate, and the lower end of thetransverse plate is connected to a second rectangular magnetic block. The liquid medicines are magnetized through magnetic induction lines between drums; the magnetic field intensities generated by coils on the left side and the right side of the rotary drum are different, the coils drive the rotary drum to rotate in a sliding groove, and the magnetic induction lines between first rectangular magnetic block sets at the inner end of the rotary drum rotate around the joints of the human body, so that molecules in the human body and liquid medicine molecules can be magnetized in horizontal and vertical magnetic fields no matter how the molecules and the liquid medicine molecules move. By means of the structure, the problems that existing arthritis physiotherapy devices are poor in liquid medicine permeation and long in physiotherapy time are solved.
Owner:HEBI CITY PEOPLES HOSPITAL

Saussurea involucrata flavonoid composition

The invention relates to a saussurea involucrata flavonoid composition, which is prepared from the following four components: rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside. A large number of animal experiments prove the pharmacodynamic activity of the flavonoid composition provided by the invention, the flavonoid composition can be used for preparing various clinically applied pain relieving and pain easing medicines and arthritis treatment medicines, and compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata, the composition has the effects of high pharmacodynamic activity, small clinical dosage, quick response, low side effect and the like. The dosage form of the medicine can be conventional tablets or capsules, and some new dosage forms of the medicine with higher absorptivity or better storability can be prepared according to the characteristics of the medicine components.
Owner:北京慧康天诚医药科技有限公司

Application of resveratrol-polylactic acid long-acting nano-microspheres in preparation of anti-osteoarthritis drug

PendingCN113967199AGive full play to the anti-inflammatory effectRealize the effect of treating osteoarthritisHydroxy compound active ingredientsAntipyreticArthritis therapyMicrosphere
The invention discloses application of resveratrol-polylactic acid long-acting nano-microspheres in preparation of an anti-osteoarthritis drug, and belongs to the field of osteoarthritis treatment. The preparation method of the nano-microspheres comprises the following steps of: jointly dissolving resveratrol and polylactic acid in dichloromethane to form an organic phase; mixing the organic phase with a PVA solution I, performing high-speed shearing under an ice bath condition to form an emulsion, then slowly dripping the emulsion into a PVA solution II, performing stirring at a low speed to volatilize an organic solvent, and collecting microspheres; and centrifuging the collected microspheres, discarding the supernate, cleaning the nano-microspheres, and performing freeze-drying to obtain the resveratrol-polylactic acid long-acting nano-microspheres. The preparation method is simple and easy to operate; the stability of the resveratrol-polylactic acid nano-microspheres is improved by optimizing preparation conditions; the resveratrol-polylactic acid nano-microspheres are suitable for industrial popularization and application; and the nano-microspheres can remarkably relieve cartilage injury, synovitis and other symptoms after knee joint cavity injection and can be used for development of drugs for treating knee osteoarthritis.
Owner:LUOYANG ORTHOPEDIC TRAUMATOLOGICAL HOSPITAL

Application of arabinoxylan sulfonate in preparation of medicine for treating osteoarthritis

ActiveCN109793751BSignificant arthritis treatment effectPromote repairOrganic active ingredientsAntipyreticSulfonateArthritis therapy
The invention discloses an application of an arabinoxylan sulfonate in preparing a medicine for treating osteoarthritis, and belongs to the technical field of medicines. The inventors of the present application have found through extensive research that arabinoxylan sulfonate has a very obvious therapeutic effect on arthritis. It can not only eliminate inflammation, but also promote cartilage repair and reverse the disease to a certain extent. Therefore, arabinoxylan sulfonate Sugar sulfonates can be used to prepare medicines for treating osteoarthritis.
Owner:GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI

A small portable electrode type infrared blue light laser arthritis treatment instrument

ActiveCN110917506BSolve the problem of not being able to save the laser angleAdjustable laser angleLight therapyArthritis therapyMedicine
The invention relates to the technical field of arthritis treatment instruments, and discloses a small portable electrode-type infrared blue light laser arthritis treatment instrument, which includes a thick rubber pad, and a tapered hole is opened on the lower end surface of the thick rubber pad. The inside is connected with the first rotating column and the second rotating column, and the inside of the thick rubber pad is provided with a round hole. The outer side of the first rotating column is connected with a swing rod, and the outer side of the second rotating column is connected with a scroll spring. The outer end is connected with a cloth belt, and the inside of the thick rubber pad is provided with a guide column. By pulling the cloth belt, the cloth belt drives the scroll spring to shrink, the cloth belt squeezes the swing rod, and the swing rod squeezes the compression spring through the first rotating column. The tension between the cloth belt and the scroll spring is different, so that the deflection of the swing rod The swing rod drives the laser light at the lower end to change the angle. This structure achieves the effect of adjusting the laser angle, thus solving the problem that the existing arthritis treatment equipment cannot adjust the laser angle.
Owner:THE FIRST AFFILIATED HOSPITAL OF JINAN UNIV

Small portable electrode type infrared blue laser arthritis therapeutic instrument

ActiveCN110917506ASolve the problem of not being able to save the laser angleAdjustable laser angleLight therapyArthritis therapyBiomedical engineering
The invention relates to the technical field of arthritis treatment instruments, and discloses a small portable electrode type infrared blue laser arthritis treatment instrument which comprises a thick rubber pad, a conical hole is formed in the lower end face of the thick rubber pad, a first rotating column and a second rotating column are connected into the thick rubber pad, and a round hole isformed in the thick rubber pad. A swing rod is connected to the outer side of the first rotating column, a volute spiral spring is connected to the outer side of the second rotating column, a cloth belt is connected to the outer end of the volute spiral spring, and a guide column is arranged in the thick rubber pad. By pulling the cloth belt, the cloth belt drives the volute spiral spring to contract, the cloth belt extrudes the swing rod, the swing rod extrudes the compression spring through the first rotating column, and the tension between the cloth belt and the volute spiral spring is different, so that the deviation angles of the swing rod are different, the swing rod drives the laser lamp at the lower end of the swing rod to change the angle, and the structure achieves the effect ofadjusting the laser angle. Therefore, the problem that the existing arthritis treatment equipment cannot save the laser angle is solved.
Owner:THE FIRST AFFILIATED HOSPITAL OF JINAN UNIV

Cartilago articularis quantitative imaging analysis method based on T2 mapping and T1 rho

The invention discloses a cartilago articularis quantitative imaging analysis method based on T2 mapping and T1 rho. The cartilago articularis quantitative imaging analysis method comprises the following steps: 1, carrying out MRI scanning; 2, dividing a lower end area of the femur; 3, conducting image evaluation; 4, measuring data; 5, carrying out statistical analysis, wherein the scanning sequence and parameters of the MRI scanning comprise conventional scanning and non-conventional scanning. According to the articular cartilage quantitative imaging analysis method based on T2 mapping and T1rho, knee osteoarthritis is a multi-factor disease, many patients suffer from the disease, and the social burden is heavy. A new strategy for treating knee osteoarthritis is early discovery and minimally invasive treatment, T2 and T1 rho values can be measured through magnetic resonance T2 mapping and T1 rho imaging technologies, change of an articular cartilage biochemical structure is reflectedfrom the molecular level before morphological change of articular cartilage, high sensitivity and specificity are achieved, and early diagnosis and treatment can be conducted on early OA.
Owner:QINGDAO MUNICIPAL HOSPITAL

Application of saussurea involucrata flavonoid composition in preparation of medicines for treating arthritis diseases

The invention relates to an application of a saussurea involucrata flavonoid composition in preparation of a pharmaceutical preparation for treating arthritis diseases, the saussurea involucrata flavonoid composition comprises four components, and the four components are rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside respectively. A large number of animal experiments prove the pharmacodynamic activity of the flavonoid composition provided by the invention, the flavonoid composition can be used for preparing various clinically applied pain relieving and pain easing medicines and arthritis treatment medicines, and compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata, the composition has the effects of high pharmacodynamic activity, small clinical dosage, quick response, low side effect and the like. The dosage form of the medicine can be conventional tablets or capsules, and some new dosage forms of the medicine with higher absorptivity or better storability can be prepared according to the characteristics of the medicine components.
Owner:北京慧康天诚医药科技有限公司

Arthritis Physiotherapy Device Benefiting Adequate Absorption of Surface Liquid Medicine

The invention relates to the technical field of arthritis treatment equipment, and discloses an arthritis physiotherapy device beneficial to the full absorption of surface medicinal liquid, comprising a sleeve, the lower end of the rotating drum is connected with a first rectangular magnetic block, and the upper end of the rotating drum is connected with a first rectangular magnet. Both sides are connected with U-shaped magnets, the inside of the drug delivery device is connected with a piston, the lower end of the piston is connected with a U-shaped rod, the outer end of the U-shaped rod is connected with a horizontal plate, and the lower end of the horizontal plate is connected with a second rectangular magnetic block. When the liquid medicine passes through the magnetic lines between the cylinders and is magnetized, the coils on the left and right sides of the cylinder generate different magnetic field strengths. The coils drive the cylinder to rotate in the chute, and the first rectangular magnetic block group at the inner end of the cylinder is connected to each other. The magnetic lines of induction rotate around the joints of the human body, so no matter how the molecules and liquid molecules in the human body move, they can be magnetized in the horizontal and vertical magnetic fields. This structure solves the problem of the existing arthritis physical therapy device. The problem of poor penetration and long treatment time.
Owner:HEBI CITY PEOPLES HOSPITAL

Application of saussurea involucrata flavonoid composition in preparation of drugs for relieving pain and easing pain

The invention relates to an application of a saussurea involucrata flavonoid composition in preparation of a pain relieving and pain easing pharmaceutical preparation, the saussurea involucrata flavonoid composition comprises four components, and the four components are rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside respectively. A large number of animal experiments prove the pharmacodynamic activity of the flavonoid composition provided by the invention, the flavonoid composition can be used for preparing various clinically applied pain relieving and pain easing medicines and arthritis treatment medicines, and compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata, the composition has the effects of high pharmacodynamic activity, small clinical dosage, quick response, low side effect and the like. The dosage form of the medicine can be conventional tablets or capsules, and some new dosage forms of the medicine with higher absorptivity or better storability can be prepared according to the characteristics of the medicine components.
Owner:北京慧康天诚医药科技有限公司

Treatment device and method for diagnosing and treating rheumatoid arthritis through traditional Chinese medicine external treatment method

The invention relates to the technical field of arthritis treatment devices, in particular to a treatment device and method for diagnosis and treatment of rheumatoid arthritis through traditional Chinese medicine external therapy. The treatment device comprises a sealing box, a smoke filtering assembly is arranged in the sealing box, a lifting plate is arranged above the sealing box, and a set of adjusting assemblies are arranged at the top of the lifting plate; according to the moxibustion device, under the action of the automatic filling assembly, moxa blocks can be automatically filled in the moxibustion process of a user, the moxibustion treatment process cannot be interrupted, the risk that the user is scalded can be effectively reduced, the moxibustion treatment efficiency is improved, and the moxibustion device is suitable for popularization and application. Under the action of the ash removal assembly, moxa ash on the surface of the moxa block can be automatically removed, and the situation that the surface of the moxa block is covered with the moxa ash, the surface temperature of the moxa block is lowered, and the moxibustion treatment effect is affected is prevented.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE

Extraction method of saussurea involucrata flavonoid composition

The invention relates to an extraction method of a saussurea involucrata flavonoid composition. The extraction method comprises the following steps: (1) alcohol extraction; (2) fine extraction; and (3) freeze-drying. According to the extraction method disclosed by the invention, the saussurea involucrata flavonoid composition containing four components, namely rutin, myristyl ether, isoquercitrin and luteolin-7-o-glucoside, can be obtained, research finds that the flavonoid composition has pharmacodynamic activity, can be used for preparing various clinically applied pain relieving and easing medicines and arthritis treatment medicines, and has the effects of high pharmacodynamic activity, small clinical dosage, quick effect, low side effect and the like compared with a Chinese patent medicine preparation prepared by directly applying saussurea involucrata.
Owner:北京慧康天诚医药科技有限公司

Arthritis Therapeutic Agent

Disclosed is a composition for preventing, treating, or alleviating arthritis, and particularly, a composition effective for preventing, treating, or alleviating arthritis comprising β-1,3-1,6-branched D-glucan. The β-1,3-1,6-branched D-glucan of the composition is characterized in that glucoses are linked via a beta-1,3 linkage between two glucose molecules and a gluclose is branched via a linkage between 1 and 6 positions of two glucose molecules in every 1-20 of the beta-1,3 linked glucoses, and the branched glucose is bound with an organic acid. Further, an arthritis therapeutic agent and a health supplement food including the composition, and a method of preventing, treating, or alleviating arthritis including administering a pharmaceutically effective amount of the composition, are disclosed.
Owner:GLUCAN

Method for preparing pellets of chondrocytes from human induced pluripotent stem cells, and use thereof

The present application claims priority for Korean patent application No. 10-2018-0072875 filed on June 25, 2018, the entire description of which is a reference for the present application. The present invention relates to a method for preparing chondrocyte pellets, comprising the steps of: (a) culturing human induced pluripotent stem cells so as to form and obtain embryoid bodies; (b) inducing the embryonic bodies obtained in step (a) to become outgrowth cells and isolating same; and (c) culturing the outgrowth cells isolated in step (b) in a pellet form. In addition, the present invention relates to: a pharmaceutical composition to be used in the treatment of arthritis, comprising the chondrocyte pellets prepared by the preparation method; or a method for preventing or treating arthritis, comprising a step of administering the chondrocyte pellets prepared by the method to an arthritis patient. Chondrocyte pellets of the present invention have a remarkably high rate of differentiationinto chondrocytes, have a uniform size, and have a homogeneous differentiation degree, and a pharmaceutical composition for treating arthritis, comprising same, has an excellent cartilage regeneration effect when administered to the site of cartilage damage, and is in an injectable form, which does not require surgery, such that through a simple procedure, the pain of a patient is relieved and acontinuous arthritis treatment effect can be provided even after the procedure.
Owner:伊普塞尔有限公司

Methylamino-pterin derivative with inhibiting nitric oxide synthetase function

This invention relates to methylaminopterin derivatives with 4-amino structure modified, which inhibit effect of nitrogen monoxide synthetase and growth of tumors. They have wide anti-cancer spectrum and little toxic side effect so as to be used in preparation of medicines for tumors, cancers, arthritis and intestinal diseases as well as chemicals for birth control.
Owner:CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products