10 results about "Arthritis therapy" patented technology

The present application belongs to the technical field of medicine, and particularly relates to a rutin composition for treating arthritis and a preparation method thereof. The rutin composition for treating arthritis comprises the following active ingredients in parts by weight: rutin 20-25 parts, typhaneoside 10-18 parts, and alisol B 11-acetate 8-15 parts. The rutin in the composition has significant anti-inflammatory and antioxidant effects, and can reduce the inflammatory response of arthritis. The typhaneoside has analgesic and anti-inflammatory properties, and the alisol B 11-acetate has anti-inflammatory and cartilage protection effects. The two components produce a synergistic effect with the rutin, and enhance the therapeutic effect of the composition. The three active ingredients are used in combination, and provide a new scheme for treating arthritis.

The invention discloses a cell lysis solution of peripheral blood mononuclear cells and application of the cell lysis solution in arthritis treatment, and belongs to the technical field of medicine preparation.The cell lysis solution of the peripheral blood mononuclear cells is prepared by the steps that gardenia powder is hydrolyzed to prepare gardenia jasminoides hydrolysate, the gardenia jasminoides hydrolysate and PBMC cells are co-cultured for anti-inflammatory induction, and the cell lysis solution of the peripheral blood mononuclear cells is obtained. And carrying out homogeneous lysis on the induced PBMC cells to obtain a PBMC lysis buffer, and mixing the PBMC lysis buffer with trehalose dihydrate, strontium chloride, selenomethionine and astaxanthin to prepare the peripheral blood mononuclear cell lysis buffer. According to the composition disclosed by the invention, the lasting exertion of the drug effect is ensured, the swelling and pain symptom of a patient can be quickly relieved after injection, the immediate treatment effect and the compliance of the patient are improved, and the technical problems that the traditional water injection is quickly cleared in an articular cavity and the effectiveness time is short are solved.

A Gynostemma pentaphyllum extract, having increased contents of damulin A, damulin B, or damulin A and damulin B, and a fractionated extract thereof exhibit superior anti-inflammatory effects and joint-health-improving effects, including cartilage-forming effects, compared to existing Gynostemma pentaphyllum extracts. Accordingly, the extract having increased contents of damulin A, damulin B, or damulin A and damulin B provides a novel pharmaceutical composition and health functional food for treating osteoarthritis, rheumatoid arthritis, gout, and psoriatic arthritis, the pharmaceutical composition and health functional food having excellent cartilage-forming and arthritis-treating effects.

The utility model relates to a stem cell culture device for arthritis treatment. The stem cell culture device comprises a culture box, a box cover, two gloves and a disinfection assembly, the incubator body is in the shape of a cuboid with the hollow interior and the missing rear side, the incubator cover is hinged to the rear side of the incubator body through a hinge shaft, visible glass is embedded in the front side of the inner wall of the incubator body, two mounting holes are formed in the visible glass, and the two gloves are mounted in the two mounting holes respectively; a placing seat for placing a culture dish is arranged on the inner bottom wall of the box cover. According to the culture device of the stem cells for arthritis treatment, the stem cells are cultured under the sterile condition, so that microbial contamination is effectively avoided, the survival rate and differentiation capacity of the cultured stem cells are improved, and the culture device is crucial to arthritis treatment; the high-quality stem cells can more effectively promote cartilage repair and relieve inflammatory response, so that the success rate of arthritis treatment is improved.

The invention discloses a lipid composition and application thereof in nucleic acid delivery. The lipid composition can be used for delivery of siRNA through intraarticular administration or subcutaneous administration, and aims to achieve arthritis treatment effects superior to those of existing commercialized proportions of lipid compositions. The lipid composition provided by the invention can be used for delivering nucleic acid drugs, and compared with a marketed LNP formula, the lipid composition has the advantages that the proportion of ionizable cationic lipid is reduced, and the proportion of PEG lipid is increased. When siRNA for treating autoimmune diseases is delivered, the lipid composition is administered through articular cavity injection or subcutaneous injection, especially has a good effect in treatment of collagen-induced rat arthritis (CIA), and remarkably reduces the arthritis score and the foot volume.

The present invention aims to provide an arthritis treatment agent containing synovial membrane-derived mesenchymal stem cells having molecules essential for joint treatment, and a method for producing the arthritis treatment agent. [Solution] According to the present invention, an arthritis treatment agent is provided which comprises synovial mesenchymal stem cells having one or more surface antigens, either integrin β1 or platelet-derived growth factor receptor β.

The invention relates to a punching positioning suspension system, which relates to the field of arthritis treatment equipment, and comprises a cross rod, a sliding block, a fixed knob, a positioning assembly, a lantern ring, a sleeve, an anchor nail and the like. The rod length of the cross rod is parallel to the first direction, the sliding block is arranged on the cross rod in a sleeving mode through the first guide hole and can move in the first direction, a positioning rod of the positioning assembly is fixed to one end of the cross rod and parallel to the second direction, and a positioning protrusion is in a conical shape and is coaxial with the first threading hole. The lantern ring is connected with the positioning rod and the cross rod and provided with a third threading hole, and the positioning rod is provided with a fourth threading hole. The sleeve and the positioning protrusion are coaxial, the cross rod and the sliding block are provided with matched tooth grooves and insertion teeth, and a threaded hole is formed in the sliding block and used for installing and fixing a rotary knob. The ground anchors comprise fixing ground anchors and ground anchors with needles. The device has the effect of improving the operation quality.

The utility model discloses a mesenchymal stem cell culture device for arthritis treatment, which comprises a culture box and a mesenchymal stem cell culture temperature adjusting mechanism, and a mesenchymal stem cell separation adjusting mechanism capable of rotating and moving is arranged above the inner wall of the culture box. The mesenchymal stem cell culture temperature adjusting mechanism is fixedly mounted on one side of the outer wall of the culture box, a culture solution replacing mechanism for mounting is arranged below the outer wall of the culture box, and a feeding pipe is connected and mounted on one side of the inner wall of the culture box. According to the mesenchymal stem cell culture device for treating arthritis, the mesenchymal stem cell separation and adjustment mechanism is arranged, so that mesenchymal stem cells can be separated, and when the mesenchymal stem cells are cultured, the mesenchymal stem cells can be compared; the mesenchymal stem cells are placed from the inner wall of the feeding pipe, so that the mesenchymal stem cells can be uniformly placed.

The application relates to the technical field of pharmaceutical preparations, in particular to a sustained-release preparation of isopropyl inosine and a preparation method and application thereof, and the sustained-release preparation of isopropyl inosine comprises a tablet core and a coating film covering the tablet core; wherein the tablet core comprises the following components in percentage by mass: 70%-74.35% of isopropyl inosine, 20%-25% of a hydrophilic gel matrix material, 5%-14.35% of a filling agent, 0.5%-2% of a disintegrating agent and 0.15%-0.5% of a lubricant; the coating film comprises the following components in percentage by mass: 70%-75% of a film control material, 10%-20% of a pore-forming agent and 10%-20% of a plasticizer; the weight of the coating film is 5%-8% of the weight of the tablet core. The application provides the sustained-release preparation of isopropyl inosine and a preparation method and application thereof; the sustained-release preparation of isopropyl inosine plays an anti-inflammatory and joint protection role by regulating T / B lymphocyte activity and inhibiting inflammatory factor release, and makes up for the defects of traditional arthritis treatment drugs, i.e. only relieving symptoms and being unable to regulate immune disorders.

The invention discloses a lipid composition and application thereof in nucleic acid delivery. Through subcutaneous administration, the lipid composition can be used for delivering siRNA, and aims to achieve arthritis treatment effects superior to those of existing commercialized proportions of lipid compositions. The lipid composition provided by the invention can be used for delivering nucleic acid drugs, and compared with a marketed LNP formula, the lipid composition has the advantages that the proportion of ionizable cationic lipid is reduced, and the proportion of PEG lipid is increased. When siRNA for treating autoimmune diseases is delivered, the lipid composition is administered through subcutaneous injection near an articular cavity, especially has a better effect in treatment of collagen-induced rat arthritis (CIA), and remarkably reduces the arthritis score and the foot volume.