30 results about "Arthritis therapy" patented technology

The invention provides application of apoptotic cell pretreated macrophages in preparation of an osteoarthritis treatment preparation, a cell preparation and a preparation method, and relates to the technical field of biomedicine.In the embodiment of the invention, based on a mouse development model and an osteoarthritis (OA) model, it is found that in the area away from the cartilage surface, the apoptotic cell pretreated macrophages are subjected to apoptotic cell pretreatment, and the apoptotic cell pretreated macrophages are subjected to apoptotic cell pretreatment in the area away from the cartilage surface; in the macrophages, the content of the interment-related LAMP1 protein is obviously higher than that of the macrophages close to the cartilage surface area, and the expression results of TGF-beta 1 and LRG1 are respectively opposite and consistent with those of the LAMP1. The invention also finds that after the chemotactic effect of apoptotic cells on macrophages is weakened, the cellular burial effect is limited, and the cartilage matrix development disorder is caused. Based on development process inspiration, the invention provides a treatment strategy: bone marrow-derived macrophages pretreated by apoptotic cells are injected into articular cavities, and a good cartilage regeneration treatment effect can be achieved in a mouse arthritis model. In addition, the bone marrow-derived macrophages pretreated by apoptotic cells can still express TGF-beta1 after being injected into the body for 3 days, so that the effect of continuously promoting cartilage regeneration is achieved.

Administration of a monoclonal Ab (mAb) that specifically targets IL-1α is useful to treating articular and extra-articular symptoms of arthritis.

The invention provides a knee osteoarthritis treatment decision-making tree system and device, and relates to the technical field of knee osteoarthritis treatment decision-making trees, and the system comprises a data receiving module, a data processing module and a result generation module. The data receiving module is used for receiving natural language text data and iconography image data of the patient and respectively preprocessing the natural language text data and the iconography image data; the data processing module comprises a text feature unit, an image feature unit and a decision unit; the decision-making unit is used for fusing the text features and the image quantization features to obtain comprehensive features; based on the comprehensive features, through a decision tree model, a treatment scheme for knee osteoarthritis is output; and the result generation module is used for sending out the treatment scheme. According to the scheme, information such as medical records of patients can be automatically analyzed, personalized treatment schemes are given, interference of human factors is reduced, real-time and objective decision support is provided for doctors, and therefore the diagnosis and treatment efficiency and effect are improved.

The present application belongs to the technical field of medicine, and particularly relates to a rutin composition for treating arthritis and a preparation method thereof. The rutin composition for treating arthritis comprises the following active ingredients in parts by weight: rutin 20-25 parts, typhaneoside 10-18 parts, and alisol B 11-acetate 8-15 parts. The rutin in the composition has significant anti-inflammatory and antioxidant effects, and can reduce the inflammatory response of arthritis. The typhaneoside has analgesic and anti-inflammatory properties, and the alisol B 11-acetate has anti-inflammatory and cartilage protection effects. The two components produce a synergistic effect with the rutin, and enhance the therapeutic effect of the composition. The three active ingredients are used in combination, and provide a new scheme for treating arthritis.

The invention discloses preparation of a drug-loaded aggregate derived nano-carrier and application of the drug-loaded aggregate derived nano-carrier in treatment of arthritis, and belongs to the technical field of nano-drug carriers. The condensate-derived nano-carrier provided by the invention is stable in a physiological environment, and the preparation method of the condensate-derived nano-carrier comprises the following steps: mixing polyphenol and an eight-arm polyethylene glycol solution to form a polyphenol-polyethylene glycol condensate, then adding a cross-linking agent, reacting, and dialyzing to obtain the condensate-derived nano-carrier. The aggregate-derived nanocarriers can be used as ROS scavengers and lubricants for ameliorating osteoarthritis; furthermore, after the polypeptide drug salmon calcitonin (sCT) is loaded, the effect of synergistically improving osteoarthritis can be achieved.

The invention discloses a cell lysis solution of peripheral blood mononuclear cells and application of the cell lysis solution in arthritis treatment, and belongs to the technical field of medicine preparation.The cell lysis solution of the peripheral blood mononuclear cells is prepared by the steps that gardenia powder is hydrolyzed to prepare gardenia jasminoides hydrolysate, the gardenia jasminoides hydrolysate and PBMC cells are co-cultured for anti-inflammatory induction, and the cell lysis solution of the peripheral blood mononuclear cells is obtained. And carrying out homogeneous lysis on the induced PBMC cells to obtain a PBMC lysis buffer, and mixing the PBMC lysis buffer with trehalose dihydrate, strontium chloride, selenomethionine and astaxanthin to prepare the peripheral blood mononuclear cell lysis buffer. According to the composition disclosed by the invention, the lasting exertion of the drug effect is ensured, the swelling and pain symptom of a patient can be quickly relieved after injection, the immediate treatment effect and the compliance of the patient are improved, and the technical problems that the traditional water injection is quickly cleared in an articular cavity and the effectiveness time is short are solved.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention provides a method for treating arthritis by using mesenchymal stem cells subjected to limited induction in vitro. Osteoarthritis is a common joint degenerative disease and is mainly characterized by cartilage injury and inflammatory response. The traditional treatment method is difficult to realize cartilage regeneration, but mesenchymal stem cells (MSC) show a prospect in joint repair due to multidirectional differentiation potential and immunomodulatory effect. According to the invention, bergenin (KGN) is utilized in vitro to induce MSC to differentiate into chondrocytes, so that the chondrogenic ability of the cells is enhanced. The inducible MSC is injected into a rat gonitis model, cartilage repair is remarkably promoted, and inflammation is reduced. Experimental results show that the method can effectively relieve arthrocele, improve the motion function and reduce the pain sensitivity. The invention not only improves the treatment effect of MSC, but also provides a safe and effective new approach for treating arthritis, and has important clinical application value.

The invention discloses an arthritis treatment system based on PLGA (poly (lactic-co-glycolic acid)) nano-particles with different morphologies and a preparation method. The arthritis treatment system comprises rod-shaped drug-loaded PLGA nano-particles and disc-shaped PLGA nano-particles modified by N-acetylneuraminic acid, the preparation method comprises the following steps: respectively preparing rod-like drug-loaded PLGA (poly (lactic-co-glycolic acid)) nano-particles and disc-like PLGA nano-particles modified by N-acetylneuraminic acid; and mixing the PLGA nano-particles with the PLGA nano-particles to obtain the arthritis treatment system based on the PLGA nano-particles with different morphologies. The invention can overcome the defects of low bioavailability and large toxic and side effects on an immune system of clinically used rheumatoid arthritis drugs, and provides a rheumatoid arthritis treatment system which can block neutrophil inflammation recruitment and does not influence the activity of neutrophil.

The invention discloses application of tyrosine hydroxylase in drugs for treating collagen-induced arthritis, and belongs to the technical field of biological medicines, TH expression is down-regulated by adopting a TH-shRNA plasmid, TH expression is up-regulated by adopting a plasmid for expressing the full length of a mouse TH gene, and the total length of the mouse TH gene is up-regulated. The TH-shRNA plasmid and the plasmid for expressing the full length of the TH gene of the mouse are respectively transfected with a collagen induced arthritis (CIA) mouse CD4 + T cell and a CIA mouse CD4 + T cell, and the imbalance condition of Th17 / Treg in the CD4 + T cell is observed. The result shows that the TH gene silencing in the CD4 + T cell of the CIA can obviously promote the imbalance of the Th17 / Treg, the TH gene overexpression in the CD4 + T cell can obviously inhibit the imbalance of the Th17 / Treg, and the Plt can obviously inhibit the TH gene overexpression in the CD4 + T cell. And 0.05%.

1. The name of the design product: osteoarthritis treatment clothes (female version). 2. The use of the design product: for wearing and assisting osteoarthritis treatment. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: combined use state reference map. 5. Omit the top view of set 1; omit the bottom view of set 1; omit the top view of set 2; omit the bottom view of set 2. 6. Other circumstances that need to be explained: the set is used and sold as a set, set 1 is a shirt, and set 2 is trousers.

A Gynostemma pentaphyllum extract, having increased contents of damulin A, damulin B, or damulin A and damulin B, and a fractionated extract thereof exhibit superior anti-inflammatory effects and joint-health-improving effects, including cartilage-forming effects, compared to existing Gynostemma pentaphyllum extracts. Accordingly, the extract having increased contents of damulin A, damulin B, or damulin A and damulin B provides a novel pharmaceutical composition and health functional food for treating osteoarthritis, rheumatoid arthritis, gout, and psoriatic arthritis, the pharmaceutical composition and health functional food having excellent cartilage-forming and arthritis-treating effects.

The utility model relates to a stem cell culture device for arthritis treatment. The stem cell culture device comprises a culture box, a box cover, two gloves and a disinfection assembly, the incubator body is in the shape of a cuboid with the hollow interior and the missing rear side, the incubator cover is hinged to the rear side of the incubator body through a hinge shaft, visible glass is embedded in the front side of the inner wall of the incubator body, two mounting holes are formed in the visible glass, and the two gloves are mounted in the two mounting holes respectively; a placing seat for placing a culture dish is arranged on the inner bottom wall of the box cover. According to the culture device of the stem cells for arthritis treatment, the stem cells are cultured under the sterile condition, so that microbial contamination is effectively avoided, the survival rate and differentiation capacity of the cultured stem cells are improved, and the culture device is crucial to arthritis treatment; the high-quality stem cells can more effectively promote cartilage repair and relieve inflammatory response, so that the success rate of arthritis treatment is improved.

The invention discloses a lipid composition and application thereof in nucleic acid delivery. The lipid composition can be used for delivery of siRNA through intraarticular administration or subcutaneous administration, and aims to achieve arthritis treatment effects superior to those of existing commercialized proportions of lipid compositions. The lipid composition provided by the invention can be used for delivering nucleic acid drugs, and compared with a marketed LNP formula, the lipid composition has the advantages that the proportion of ionizable cationic lipid is reduced, and the proportion of PEG lipid is increased. When siRNA for treating autoimmune diseases is delivered, the lipid composition is administered through articular cavity injection or subcutaneous injection, especially has a good effect in treatment of collagen-induced rat arthritis (CIA), and remarkably reduces the arthritis score and the foot volume.

The invention belongs to the technical field of medicines, and particularly relates to a rutin composition for treating arthritis and a preparation method thereof. The rutin composition for treating arthritis is prepared from the following active ingredients in parts by weight: 20 to 25 parts of rutin, 10 to 18 parts of typha orientalis glucoside and 8 to 15 parts of a resveratrol derivative. The rutin in the composition has remarkable anti-inflammatory and anti-oxidation effects and can relieve joint inflammation reaction, the tympanoside has analgesic and anti-inflammatory characteristics, the rutagenol derivative has anti-inflammatory and cartilage protection effects, the tympanoside and the rutagenol derivative have a synergistic effect with the rutin, the treatment effect of the composition is enhanced, and the three active ingredients are matched for use, so that the curative effect of the composition is improved. And a new scheme is provided for arthritis treatment.

The present invention aims to provide an arthritis treatment agent containing synovial membrane-derived mesenchymal stem cells having molecules essential for joint treatment, and a method for producing the arthritis treatment agent. [Solution] According to the present invention, an arthritis treatment agent is provided which comprises synovial mesenchymal stem cells having one or more surface antigens, either integrin β1 or platelet-derived growth factor receptor β.

1. The name of the design product: osteoarthritis treatment clothes (male version). 2. The use of the design product: for wearing and assisting osteoarthritis treatment. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: combined use state reference map. 5. Omit the top view of set 1; omit the bottom view of set 1; omit the top view of set 2; omit the bottom view of set 2. 6. Other circumstances that need to be explained: the set is used and sold as a set, set 1 is a shirt, and set 2 is trousers.

The invention provides an application of a secreting type curl-related protein in preparation of a medicine for treating arthritis and the medicine for treating the arthritis, and belongs to the technical field of biology. According to the present invention, the research results show that the secreting type curling-related protein has good arthritis treatment effect, can significantly up-regulate the expression level of the II type collagen marker COL2A1 and the SOX family transcription factor SOX5 in the damaged cartilage cells, and can promote the expression of the cell cycle-related protein Ki67 to achieve the enhancement of the cartilage cell proliferation ability. Meanwhile, the SFRP can regulate the polarization phenotype of human synovial macrophages in a targeted manner and remarkably inhibit expression of a proinflammatory M1 macrophage marker iNOS, so that release of inflammatory factors in a synovial tissue inflammatory microenvironment is reduced, synovial inflammation is regulated in a targeted manner, and arthralgia is remarkably relieved.

An arthritis treatment system includes a cooling treatment mechanism for administering a cooling treatment protocol to a patient. The system also includes a heating treatment mechanism for administering a heating treatment protocol to the patent, distinctly and simultaneously with the cooling treatment protocol. The system further includes a controller for controlling both the cooling and heating treatment mechanisms. The arthritis treatment system simultaneously provides the cooling and heating treatment protocols to the patent, and the controller algorithmically adjusts the cooling and heating treatment protocols.

1. Name of the designed product: Acupuncture box (for treating arthritis). 2. Use of the designed product: for storing acupuncture. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The invention discloses a traditional Chinese medicine preparation for treating gout and rheumatic arthritis and a preparation method thereof, and relates to the technical field of gout and arthritis treatment, the traditional Chinese medicine preparation is prepared from the following raw materials: radix stephaniae tetrandrae, ovateleaf holly bark, ginger processed cortex magnoliae officinalis, honeysuckle stem, concha arcae, semen plantaginis, semen coicis, semen raphani, lycopodium clavatum, rhizoma dioscoreae septemlobae, dandelion, moutan bark and garden balsam stem; the traditional Chinese medicine composition is prepared from, by weight, 8-14 g of radix stephaniae tetrandrae, 10-20 g of ovateleaf holly bark, 10-20 g of ginger processed cortex magnoliae officinalis, 15-25 g of honeysuckle stem, 12-18 g of concha arcae, 6-15 g of semen plantaginis, 25-36 g of semen coicis, 12-16 g of semen raphani, 12-18 g of lycopodium clavatum, 10-20 g of rhizoma dioscoreae septemlobae, 20-40 g of dandelion, 10-20 g of moutan bark and 12-15 g The traditional Chinese medicine preparation for treating gout and rheumatic arthritis can effectively improve the kidney function and promote uric acid to be discharged out of a body, and has the effects of diuresis and detumescence; the traditional Chinese medicine composition can clear away heat and toxic materials.

The invention relates to the field of traditional Chinese medicine preparations, and discloses a gel for treating arthritis and a preparation method thereof, the gel is prepared from the following raw materials in percentage by mass: 1.0-2.0% of carbomer-940, 5-15% of glycerol, 0.25-0.75% of triethanolamine, 10% of angelica sini decoction concentrated solution and the balance of distilled water; the angelica sini decoction concentrated solution comprises the following raw materials in parts by weight: 8-10 parts of angelica, 8-10 parts of cassia twig, 8-10 parts of Chinese herbaceous peony, 2-4 parts of asarum, 5-7 parts of liquorice, 5-7 parts of tetrapanax papyriferus and 4-6 parts of jujube. The preparation method of the gel for treating arthritis comprises the following steps: S1, preparing an angelica sini decoction concentrated solution; s2, preparing a gel matrix; s3, mixing the angelica sini decoction concentrated solution with the gel matrix; s4, adjusting the pH value; and S5, inspecting and packaging a finished product. The gel for treating arthritis can improve the drug effect, enhance the drug permeability and targeting property, improve the patient experience, is convenient to use, reduces the pain, can reduce the side effect risk, and provides a better scheme for arthritis treatment.

The invention relates to the technical field of traditional Chinese medicinal material component proportion program control systems, and discloses a traditional Chinese medicinal material component proportion regulation and control system and method for rheumatoid arthritis treatment. The system comprises a rheumatoid arthritis symptom evaluation module, a rheumatoid arthritis symptom treatment traditional Chinese medicine parameter processing module and a rheumatoid arthritis symptom treatment traditional Chinese medicine regulation and control module. Text character recognition is performed by scientifically storing total dosage parameters of traditional Chinese medicinal materials for treating rheumatoid arthritis symptoms and combining an intelligent search algorithm with standard symptom recognition parameters of rheumatoid arthritis of a patient, so that the total dosage of the traditional Chinese medicinal materials for treating the rheumatoid arthritis symptoms of the patient is efficiently and autonomously searched and analyzed; therefore, the usage amount of traditional Chinese medicinal materials for treating rheumatoid arthritis of patients is accurately judged. Based on the proportion of traditional Chinese medicinal materials for treating rheumatoid arthritis symptoms of patients and the total dosage of the traditional Chinese medicinal materials in combination with numerical measurement, the component types and the dosage of the traditional Chinese medicinal materials required for treating the rheumatoid arthritis symptoms of the patients are scientifically counted, and intelligent regulation and control of the proportion of the traditional Chinese medicinal materials for treating the rheumatoid arthritis is realized. And the efficiency of obtaining traditional Chinese medicinal materials for rheumatoid arthritis patients is improved.

The present invention relates to an arthritis correction process monitoring system based on motion monitoring, which integrates a monitoring host, a pressure sensor, an image acquisition module, a storage module and a user terminal. The system monitors the pressure distribution of both feet during walking in real time through the pressure sensor in the shoe, and combines the infrared and visible light cameras in the patient's activity area to collect dynamic images of key body parts marked by the wearer's light emitter. Using a deep learning algorithm, the system can accurately align infrared and visible light images, integrate pressure changes, joint movements and gait profile data, and realize intelligent analysis and prediction of the correction stage. The system not only provides personalized correction effect feedback, but also optimizes the treatment plan and improves the accuracy and efficiency of arthritis management. This technology greatly improves the patient's treatment experience through non-invasive and real-time monitoring, while providing doctors with powerful remote monitoring and analysis tools, promoting the modernization of arthritis treatment.

The invention relates to a punching positioning suspension system, which relates to the field of arthritis treatment equipment, and comprises a cross rod, a sliding block, a fixed knob, a positioning assembly, a lantern ring, a sleeve, an anchor nail and the like. The rod length of the cross rod is parallel to the first direction, the sliding block is arranged on the cross rod in a sleeving mode through the first guide hole and can move in the first direction, a positioning rod of the positioning assembly is fixed to one end of the cross rod and parallel to the second direction, and a positioning protrusion is in a conical shape and is coaxial with the first threading hole. The lantern ring is connected with the positioning rod and the cross rod and provided with a third threading hole, and the positioning rod is provided with a fourth threading hole. The sleeve and the positioning protrusion are coaxial, the cross rod and the sliding block are provided with matched tooth grooves and insertion teeth, and a threaded hole is formed in the sliding block and used for installing and fixing a rotary knob. The ground anchors comprise fixing ground anchors and ground anchors with needles. The device has the effect of improving the operation quality.

The utility model discloses a mesenchymal stem cell culture device for arthritis treatment, which comprises a culture box and a mesenchymal stem cell culture temperature adjusting mechanism, and a mesenchymal stem cell separation adjusting mechanism capable of rotating and moving is arranged above the inner wall of the culture box. The mesenchymal stem cell culture temperature adjusting mechanism is fixedly mounted on one side of the outer wall of the culture box, a culture solution replacing mechanism for mounting is arranged below the outer wall of the culture box, and a feeding pipe is connected and mounted on one side of the inner wall of the culture box. According to the mesenchymal stem cell culture device for treating arthritis, the mesenchymal stem cell separation and adjustment mechanism is arranged, so that mesenchymal stem cells can be separated, and when the mesenchymal stem cells are cultured, the mesenchymal stem cells can be compared; the mesenchymal stem cells are placed from the inner wall of the feeding pipe, so that the mesenchymal stem cells can be uniformly placed.

The application relates to the technical field of pharmaceutical preparations, in particular to a sustained-release preparation of isopropyl inosine and a preparation method and application thereof, and the sustained-release preparation of isopropyl inosine comprises a tablet core and a coating film covering the tablet core; wherein the tablet core comprises the following components in percentage by mass: 70%-74.35% of isopropyl inosine, 20%-25% of a hydrophilic gel matrix material, 5%-14.35% of a filling agent, 0.5%-2% of a disintegrating agent and 0.15%-0.5% of a lubricant; the coating film comprises the following components in percentage by mass: 70%-75% of a film control material, 10%-20% of a pore-forming agent and 10%-20% of a plasticizer; the weight of the coating film is 5%-8% of the weight of the tablet core. The application provides the sustained-release preparation of isopropyl inosine and a preparation method and application thereof; the sustained-release preparation of isopropyl inosine plays an anti-inflammatory and joint protection role by regulating T / B lymphocyte activity and inhibiting inflammatory factor release, and makes up for the defects of traditional arthritis treatment drugs, i.e. only relieving symptoms and being unable to regulate immune disorders.

A method for optimizing osteoarthritis (OA) treatment by promoting chondrocyte cell proliferation and migration using thrombomodulin (TM) or soluble TM. This method involves blocking interleukin 1β (IL-1β)-mediated signaling to prevent the loss of bone integrity and maintain knee joint function. Additionally, the administration of miR-up-TM enhances the expression of TM protein, thereby protecting against cartilage damage and potentially preventing cartilage-related diseases.

The present invention provides an environment-responsive drug-loaded microsphere for treating arthritis, a preparation method thereof and an application thereof. By using the microfluidic technology, polyethylene glycol diacrylate molecules undergo a polymerization reaction under the action of a photoinitiator to form a first hydrogel network structure, and modified polyethylene glycol and chitosan molecules undergo a chemical reaction to generate Schiff base bonds to form a second hydrogel network structure, thereby constructing a drug-loaded microsphere with a double network structure. The preparation method of the present invention is simple, the preparation period is short, the particle size of the obtained drug-loaded microsphere is controllable, the particle size distribution is uniform, the batches are stable, and the physical and chemical properties are relatively uniform. The drug-loaded microsphere of the present invention has good application value in the field of drug carriers, has a good encapsulation effect on CST-14, the hydrogel microsphere loaded with CST-14 has a good effect on the treatment of arthritis, and has a stimulus-responsive property and can release drugs according to the change of pH.

The invention discloses a lipid composition and application thereof in nucleic acid delivery. Through subcutaneous administration, the lipid composition can be used for delivering siRNA, and aims to achieve arthritis treatment effects superior to those of existing commercialized proportions of lipid compositions. The lipid composition provided by the invention can be used for delivering nucleic acid drugs, and compared with a marketed LNP formula, the lipid composition has the advantages that the proportion of ionizable cationic lipid is reduced, and the proportion of PEG lipid is increased. When siRNA for treating autoimmune diseases is delivered, the lipid composition is administered through subcutaneous injection near an articular cavity, especially has a better effect in treatment of collagen-induced rat arthritis (CIA), and remarkably reduces the arthritis score and the foot volume.