185 results about "Hypofunctions" patented technology

This invention relates to a remedy for neuropathy, such as nerve injury, nerve degeneration, and hypofunction upon nerve grafting, which contains as the active ingredient galectin-1 having an amino acid sequence represented by SEQ ID NO:1 or its derivative; a protein having the amino acid sequence represented by SEQ ID NO:1 or one having a homology of 90% or more at the amino acid level with the sequence of SEQ ID NO:1 and carrying a disulfide bond(s) at least between Cys at the 16-position (Cys 16) and Cys at the 88-position (Cys 88) among cystein residues at the 2-position (Cys 2), 16-position (Cys 16), 42-position (Cys 42), 60-position (Cys 60), 88-position (Cys 88) and 130-position (Cys 130); and a process for producing the galectin-1 or its derivative protein by using an affinity column having an antibody to the above protein.

The present invention relates to a compound medicine for preventing and curing angiocardiopathy and cerebrovascular disease, belonging to the field of chemical medicine. It is characterized by that said compound medicine includes sexual hormones medicine, lipid-reducing medicine, hypotenser, hypoglycemic medicine and anticoagulant medicine. Said compound medicine can be made into various dosage forms. Besides, said compound medicine also can be used for curing the diseases of climacteric syndrome, osteoporosis, endometrial carcinoma, diabetes and metabolic syndrome, etc.

The invention discloses health-care medicinal liquor with the function of invigorating kidney and a preparation method thereof which belong to the technical field of traditional Chinese medicine. The health-care medicinal liquor is prepared from the following raw materials in weight portion: distilled spirit, and Chinese herbal medicines of aweto, ginseng, fructus schizandrae, medlar, actinolite, male silk moth, astragalus root, herba epimedii, herba cistanches, semen alli tuberosi, yam and tuckahoe. The total effective rate of the health-care medicinal liquor for renal deficiency, renal hypofunction patients, nephropathy, prostatitis, rheumatoid arthritis, cervical spondylopathy and lumbar intervertebral disc protrusion can reach over 90 percent. The health-care medicinal liquor also has auxiliary treatment and health-care function on gastritis, gastric cold, intestinal inflammation, irregular menses, adnexitis, hyperplasia of mammary glands, hypopiesis and arrhythmia. The health-care medicinal liquor has a simple concoction process, available material source, no risk in production, transportation and storage, and wide market prospect.

The invention discloses a Chinese medicinal composition for treating concrement, which is characterized in that: the Chinese medicinal composition is prepared from the following components: 5 to 20g of Chinese angelica, 5 to 20g of combined spicebush root, 5 to 20g of corydalis, 5 to 25 g of white paeony root, 5 to 25g of immature bitter orange, 5 to 20g of officinal magnolia bark, 5 to 25g of elecampane, 5 to 20g of nutgrass galingale rhizome, 5 to 20g of finger citron, 5 to 25g of common burreed rhizome, 5 to 25g of zedoary, 5 to 20g of rhubarb, 80 to 150g of longhairy antenoron herb, 5 to 20g of areca seed, 5 to 25g of turmeric root-tuber, 5 to 20g of Chinese thorowax root, 5 to 25g of Chicken's gizzard-membrane and 3 to 6g of liquoric root. The Chinese medicinal composition can effectively improve clinical symptoms to resolve tetany and relieve pain, maintains and improves gallbladder function, prevents and treats the concrement, and has the effects of coursing liver and disinhibiting gallbladder, abating jaundice, softening and loosening scar tissue, relieving inflammatory response and the like so as to promote the concrement to be moved, dissolved and discharged. The Chinese medicinal composition can effectively improve symptoms of uronephrosis, nephrcystosis, nephrauxe, renal deformation, nephrarctia and renal hypofunction, combines large, medium and small concrement, and has reliable cure rate.

The invention relates to a dendrobium candidum compound preparation capable of regulating the function of a human body in a two-way manner and a preparation method thereof, and the dendrobium candidum compound preparation is prepared from the following traditional Chinese medicine pharmaceutical raw materials in proportion by weight: 2g-40g of dendrobium candidum, 2g-40g of Chinese caterpillar fungus, 5g-80g of American ginseng, 5g-80g of membranous milkvetch root, 5g-80g of lucid ganoderma, 2g-40g of sanchi, 5g-80g of manyprickle acanto-panax root and 5g-40g of bee propolis. The dendrobium candidum compound preparation provided by the invention has the functions of nourishing yin, strengthening kidney, benefiting qi, invigorating spleen, strengthening and consolidating body resistance, tranquillizing, beautifying skin, prolonging life and promising longevity. The dendrobium candidum compound preparation is suitable for people groups in sub-health states and middle-aged and elderly people with health care hypofunction, and can also be used for rehabilitation of patients with cancers after chemicotherapy.

A water-soluble active component of the fermented cordyceps is prepared through extracting in water, concentrating and spray drying. It can be used to prepare medicine and health-care product or food for preventing and treating sexual hypofunction, improving physique and endurance, and relieving fatigue.

The invention discloses a drug for treating diabetes and preparation method of the drug. The raw materials proportioned by weight are 10-20 parts of Radix Astragali, 5-15 parts of Radix Ophiopogonis, 5-15 parts of trichosanthes root, 5-15 parts of fragrant solomonseal rhizome, 5-15 parts of Dendrobium nobile, 5-15 parts of wolfberry fruit, 5-15 parts of kudzu root, 5-15 parts of dried rhizome of rehmannia, 3-6 parts of Rhizoma Anemarrhenae, 5-15 parts of rhizome of common yam and 10-20 parts of Salvia miltiorrhiza. The drug of the invention has the effects of supplementing qi, nourishing yin,promoting the production of body fluid to quench thirst, clearing away heat, invigorating blood circulation and improving eyesight. The drug is obviously effective in treating the insulin hypofunction caused diabetes which is associated with disturbed metabolisms of substances and carbohydrates and with increase of blood sugar level. The drug also has the effects of treating asthenia of kidney, poor vision and visual deterioration, protecting liver, reducing blood fat and sugar and enhancing immunity.

The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.

The present invention is directed to quinolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

The present invention relates to a composition for organ preservation, comprising an inulin type fructan as an active ingredient. The composition for organ preservation can suppress the hypofunction of an organ and damage to a histological structure and can improve the state of preservation of the organ in the course of organ transplantation and the like.

A method of treating hypoparathyroidism in a human DiGeorge syndrome subject comprises (a) implanting thymus tissue into the subject in an amount effective to treat the DiGeorge syndrome; and (b) implanting, preferably concurrently implanting, parathyroid tissue into the subject in an amount effective to treat the hypoparathyroidism.

The present invention discloses a medicine and a preparation method for preventing and treating kidney essence deficiency. The medicine provided by the present invention has the efficacy of nourishing yin and tonifying yang, nourishing the kidney and strengthening the essence. The present invention can prevent and cure various diseases caused by kidney essence deficiency, such as growth retardation in children, oligospermia and sterility in male, less menstruation and amenorrhea in female, sexual deficiency, adult presenility, alopecia and loose teeth, dim eyesight and ear ringing, amnesia, foot atrophic debility, sexual hypofunction and osteoporosis. The present invention includes the following raw materials: prepared rehmannia root, yam, asiatic cornelian cherry fruit, barbary wolfberry fruit, dodder seed, deerhorn glue, tortoise-shell glue, ginseng, Chinese angelica, scurfy pea, eucommia, pachyma cocos, cassia bark, dried citrus peel and amomum villosum. According to the properties of each Chinese medicine, all raw materials are made into condensed water-paste pills, condensed water-honeyed pills or capsules through procedures of air drying, freeze drying and grinding, decocting and extracting, decompressed drying and grinding and disinfecting, which pertains to the art of Chinese medicine. The present invention has the advantages of scientific production method, no change of effective ingredients and significant prevention and cure effect.

Agents for protecting or ameliorating pancreatic cells and tissues which contains as the active ingredient a neurotrophic factor such as BDNF. By using these drugs, degenerative dropout of pancreatic cells and pancreatic hypofunction caused by diabetes, acute / chronic pancreatitis, etc. can be efficaciously prevented and treated.

A glycoside extract DSS-A-N-30 of an anoelica sinensis herbaceous peony prescription comprises an integral glycoside (herbaceous peony glycoside and white peony root glycoside) of 36.0-44.0 of the weight percentage calculated by the weight of the extract, wherein the anoelica sinensis herbaceous peony prescription comprises anoelica sinensis, herbaceous peony, poria cocos wolf, white atractylodes rhizome, rhizoma alismatis, and chuanxiong rhizome of which the weight proportion of the compatibility is 3:16:4:4:8:8. The products or the medicament compositions with the extract are used as the products or the medicament purposes for curing the diseases which are related with the ache, senescence, and hypofunction and disorder of reproductive endocrine, in particular to dysmenorrheal, unregulated menstrual flow, abortion, climacteric metancholia, senile dementia, hypofunction of ootheca and the like.

The invention relates to a health Abelmoschus manihot hard gelatin tablet wherein the weight percents of the active constituent raw material include Abelmoschus manihot seed powder 25-75%, Abelmoschus manihot extract 10-60%, and balancing amount of iso-vitamin C sodium, the content of total flavones is greater than 30mg / 100g. The functions of the capsule include improving human body immunity, enhancing constitution, lowering blood fat and blood pressure, improving microcirculation, improving human body's anti-oxidizing ability, and regulating kidney hypofunction.

The invention relates to a functional feed, in particular to the functional feed for preventing and treating a white liver lesion of micropterus salmoides, and a preparation method thereof. The feed comprises, by weight percentage, 15-25% of fish meal, 20-35% of chicken powder, 16-22% of soybean meal, 8-15% of flour, 4-8% of squid extractum, 1-2% of calcium dihydrogen phosphate, 1-2% of a multi-vitamin premix, 1-2% of a multi-mineral premix, 2-4% of fish oil, 1-2% of soybean oil, 1-2% of phosphatide oil, 2-7% of corn protein powder, 0.2-0.5% of pennisetum sinese herb extract, 0.1-0.5% of mulberry leaf fermentation liquid, and 0.1-0.3% of red rooted saliva root fermentation liquid. Compared with a common puffed feed for the micropterus salmoides, a feed formula provided by the invention can meet the basic nutrient demands of juvenile fishes, medium fishes and adult fishes of the micropterus salmoides, also can effectively enhance exchangeable backflow between artery blood and vein blood in hepatic tissue blood circulation, and has a good prevention effect and a repair treatment effect on the white liver lesion and hepatic tissue hypofunction caused by the white liver lesion.

The invention discloses a medicine for treating thyroid hypofunction, comprising the following medicines by fixed weight ratio: monkshood, cassia twig, rhizoma zingiberis, Codonopsis pilosula, radix astragali, bighead atractylodes rhizome, Indian buead, liquorice and the like. The raw materials of the medicine are easy to obtain and low in cost; and the medicine has the advantages of short course of treatment, excellent curative effect and no side effect.

An infusion pump is disclosed comprising control unit, container, actuation unit and detection unit. The container can store medicinal liquid for treating hypogonadotropic hypogonadism. The control unit can receive external control signal comprising infusion interval, concentration of medicinal liquid and dose of medicament for treating hypogonadotropic hypogonadism at each infusion. The control unit is configured to activate actuation unit based on infusion interval to cause medicinal liquid to flow out of container. The detection unit can detect output of medicinal liquid from container and feed it back to control unit. The control unit is configured to activate actuation unit based on dose at each infusion, concentration of medicinal liquid and fed-back output of medicinal liquid. According to the invention, sustained, automatic infusions of the medicament for treating hypogonadotropic hypogonadism are allowed without patient intervention. As a result, intelligent infusion of medicament is achieved in an easy and efficient manner.

A use of an inhalable powder formulation for preventing or treating an NMDA receptor hypofunction-related disease, a method for preventing or treating an NMDA receptor hypofunction-related disease in a subject, which comprises administering a therapeutically effective amount of an inhalable powder formulation comprising growth hormone (GH) to the subject in need thereof, and an inhalable powder formulation for preventing or treating an NMDA receptor hypofunction-related disease comprising GH as an active ingredient are provided.

The present invention discloses one kind of health medicinal wine with functions of invigorating kidney and resisting rheumatism and its preparation process, and belongs to the field of Chinese medicine technology. The health medicinal wine is prepared with spirit, ginseng, schisandra, wolfberry fruit, safflower, male silkworm moth and other eight kinds of Chinese medicinal materials. It has certain curative effect on kidney deficiency, kidney hypofunction, nephropathy, prostatitis, rheumatic arthritis, etc.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The invention provides a nitrol ointment, preparation method and application thereof, wherein the ointment comprises nitroglycerin, emulsifying agent, deflocculating agent and water, it can be used for treating male erection dysfunction and female sex hypofunction. The advantages of the invention include increased medicament stability, strong safety, simple process for manufacturing, and low cost of manufacture.

The invention relates to a traditional Chinese medicine having functions of invigorating kidney and strengthening yang, and supporting the healthy energy, which is prepared mainly by materials of the following weight ratio (%): 3-5 fructus lycii, 3-5 prepared radix rehmanniae, 1-3 dodders, 1-3 herba epimedii, 3-5 cistanche salsa, 1-3 panax ginseng, 1-3 glossy ganoderma, 5-7 polyrhachis vicina roger, and 5-7 bee pollen, or optional adding with 5-7 propolis, 5-7 royal jelly, and 40-50 honey, in particular the accessories of the prescription are medicinal liquor prepared preferred by 50-60% kaoliang spirit of 200-600. Each material of the prescription can cooperate with each other, complement of yin and yang, thus has effect of enhancing physical strength. The traditional Chinese medicine of the invention has functions of invigorating kidney and strengthening yang, and supporting the healthy energy, strengthening body and removing fatigue, and the like, which is applicable for treating impotence, spermatorrhea, premature ejaculation and sexual hypofunction of elderly person caused by kidney deficiency, or used for enhancing immunity, regulating endocrine for a person having chronic diseases or weak body or an aged person, and the invention is suitable to adjuvant treatment postoperation or followed radiotherapy and chemotherapy of a tumor patient.

The present invention provides a muscular amino acids and peptides and nucleosides injection, which is extracted from the muscle and the cardiac muscle of healthy rabbit and is a freeze-drying agent which is prepared by the sterilized water solution containing the compositions of polypeptide, amino acids, nucleosides, nucleotides, etc. The muscular amino acids and peptides and nucleosides is used for the adjuvant therapy of brain hypofunction and peripheral nerve disease caused by cerebral apoplexy and cerehral circulation insufficiency. The present invention belongs to the technical field of medicine. The invention introduces a preparing method which comprises the steps of cleaning, cutting into blocks, homogenizing, deep freezing, heating to boiled, separating the supernatant, depositing with acid and the base, depositing with the base, hot pressing, deep freezing, ultra-filtering, detecting, adjusting the proportion between the polypeptide and the hypoxanthine, and ultra-filtering. The muscular amino acids and peptides and nucleosides injection is prepared through the steps of sterilizing filtering, filling into containers, and sterilizing. An appropriate amount of accessory is added and the steps of sterilizing filtering, filling into containers, and freeze drying are executed for preparing the muscular amino acids and peptides and nucleosides for injection. The muscular amino acids and peptides and nucleosides and the preparing method of the invention have the advantages of excellent convenience, excellent wholeness, ensured product which satisfies the national standard, guaranteed virus blanching, injection sterilization F0 larger than 8, and high level of sterilizing guaranteeing.

The invention relates to a rosemary sports drink, which comprises the following raw materials in parts by mass: 50 parts of a rosemary extracting solution, 50 parts of medlar water, 1-6 parts of stevia rebaudian water, 1-6 parts of cane sugar, 0.001-0.006 part of ascorbic acid, 0.01-0.06 part of glucose, 0.01-0.042 part of citric acid, and 50 parts of water. The rosemary sports drink disclosed by the invention is free from chemical synthetic matters, such as essence and pigment, safe to eat, free from any toxic or side effect, and good in mouth feel; nutritional components lost in motion of a human body can be supplied; and the rosemary sports drink is not only applied to athletes but also applied to crowds using brains excessively and crowds suffering from chronic diseases, such as hypofunction.

The present invention is directed to pyrazolopyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

The invention discloses novel application of forsythin belonging to active components of natural medicinal plants, and particularly relates to application of forsythin as the only active ingredient to preparation of a medicine for improving a cognitive function and treating Alzheimer's diseases. Animal and cell research results indicate that the forsythin has the exact function of improving the cognitive function and can remarkably improve the spatial learning and memory ability of animals in an aging and Alzheimer's disease model, the level of a center monoamine neurotransmitter of an old-aged animal is increased, the genetic expression of presenilin 2 in a rat brain of an Alzheimer's disease model is reduced, and the survival rate of neuroblastoma cells induced by beta-amyloid protein is increased. The forsythin is matched with relevant auxiliary materials, a health care product or a medicine for purposefully improving the cognitive function and treating the Alzheimer's diseases can be prepared by a conventional preparation method, and the health care product and the medicine can be used for delaying and improving relevant diseases of cognitive hypofunction such as the course of the Alzheimer's diseases, enhancing the healthy quality and the life quality of old people and realizing a healthy aging social value.

Provided are effective and highly safe agents, medicaments and the like for ameliorating various disorders caused by brain hypofunction. Also provided is a preventing or ameliorating agent for brain hypofunction containing N-acetyl-D-mannosamine, a pharmaceutical composition for preventing, ameliorating or treating disorders due to brain hypofunction, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier, and a food comprising N-acetyl-D-mannosamine added thereto.