19 results about "Hypofunctions" patented technology

The invention discloses a traditional Chinese medicine composition, a traditional Chinese medicine extract, a pharmaceutical preparation and application for treating hypoovarian reserve function. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 12 to 18 parts of radix astragali seu hedysari, 9 to 15 parts of radix angelicae sinensis, 9 to 15 parts of fructus ligustri lucidi, 9 to 15 parts of fructus mori, 9 to 15 parts of semen cuscutae, 6 to 12 parts of cornu cervi degelatinatum, 7 to 13 parts of tortoise shell and 7 to 13 parts of radix cyathulae. The traditional Chinese medicine composition, the traditional Chinese medicine extract and the pharmaceutical preparation are low in cost and high in safety, and can remarkably improve the ovarian function of an elderly patient suffering from hypoovarian reserve function, increase the number of sinus follicles and improve the follicle quality.

The invention provides a traditional Chinese medicine composition for treating hypothyroidism and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. In the traditional Chinese medicine composition, fomes officinalis ames, stigma croci, aloe, resina scammoniae, kalimeris indica, radix aucklandiae, pogonatherum crinitum and rhizoma nardostachyos are taken as main medicines of a formula, asamur, cortex cinnamomi, rhizoma calami, myrrh branches, euphorbia pekinensis resina, common jasminum seeds and champignon are taken as auxiliary medicines of the formula, and vernonia anthelmintica, hypericum perforatum, black pepper and white pepper are taken as correction medicines of the formula. The traditional Chinese medicine composition is clear in compatibility, has the effects of promoting blood circulation to remove blood stasis, eliminating cold to stop pain, relaxing tendons and activating collaterals and tonifying the liver and kidney, can effectively treat hypothyroidism, and is definite in curative effect on improvement of clinical manifestations and laboratory indexes of patients, safe and reasonable.

The present invention relates to methods of treating hypogonadism in a male subject through administering intranasally to the male subject an intranasal testosterone bio-adhesive gel formulation to deliver a therapeutically effective amount of testosterone. In particular, the testosterone therapy of the invention remains effective if an allergic rhinitis event occurs in the male during the treatment or when the male subject uses a topical nasal vasoconstrictor or a topical intranasal decongestant during the hypogonadism treatment. Further, the present invention relates to a method of preventing Hie occurrence of an allergic rhinitis event in a male, who is undergoing a hypogonadism treatment with an intranasal testosterone bio-adhesive gel. In certain embodiments, the intranasal testosterone bio-adhesive gel formulation according to the invention comprises 4.0% and 4.5% testosterone.

Disclosed are a compound that is a parathyroid hormone receptor 1 agonist and a method useful for preventing or treating osteoporosis, fractures, osteomalacia, arthritis, thrombocytopenia, hypoparathyroidism, hyperphosphatemia, or neoplastic calcification.

The invention belongs to the technical field of microorganisms, and particularly discloses application of lactobacillus rhamnosus fermented milk in a product for improving male functions. According to the application, the new application of the lactobacillus rhamnosus B6 (CGMCC No.13310) fermented milk in the aspect of improving male functions is disclosed for the first time, and the new application is specifically characterized by improving male fertility desire, reproductive capacity, seminiferous tubule dysfunction and spermatogenesis, testis oxidative stress activity, testis testosterone synthesis and sperm quality; the strain has a potential value of producing a gain substance for improving the male function by fermenting skimmed milk, and also prompts that the fermented milk has a potential application prospect for enhancing the male function.

The invention provides a traditional Chinese medicine composition for treating thyroid postoperative parathyroid hypofunction (hereinafter referred to as subthyroid hyperthyroidism). Specifically, the invention develops a traditional Chinese medicine composition for treating thyroid postoperation combined parathyroid hypofunction for the first time, and the traditional Chinese medicine composition is prepared from the following raw material medicines: 240g of raw astragalus membranaceus, 12g of angelica sinensis, 9g of radix paeoniae rubra, 6g of ligusticum wallichii, 6g of lumbricus, 6g of fried peach kernel, 6g of safflower and 12g of kudzu vine root. The traditional Chinese medicine composition can improve the PTH recovery rate, shorten the PTH recovery time, reduce the total calcium supplement amount, relieve low-calcium clinical symptoms caused by thyroid subtraction after the thyroid surgery to a certain extent, promote qi and blood circulation of the whole body after the surgery, prevent thrombosis, promote wound healing and shorten the hospitalization time at the same time, meets the clinical requirements, and is worthy of popularization and application. The current situation that traditional Chinese medicine prescriptions combined with parathyroid hypofunction after thyroid surgery are insufficient is made up.

The application discloses a processed American ginseng product for treating hypothyroidism, which is prepared from American ginseng as raw material and is obtained through nine times of steaming and drying; the black American ginseng is crushed into coarse powder, and is extracted three times through heating reflux extraction with 50-70% ethanol solution, and each time is 1-3 hours, and the extract is concentrated to obtain the product. The application further discloses application of the processed American ginseng product in preparation of a medicine for treating hypothyroidism. The processed American ginseng product can improve the unbalanced hypothalamus-pituitary-thyroid axis function of a hypothyroidism patient, promote secretion of thyroid hormone, improve thyroid function, and has a remarkable improvement effect on hypothyroidism.

The present invention relates to a PTH compound for use in the treatment of chronic hypoparathyroidism, wherein the treatment comprises the step of administering to a patient having chronic hypoparathyroidism a once weekly dose of a PTH compound and wherein prior to initiation of the treatment the patient is clinically determined as being no longer dependent on active vitamin D and calcium supplement to maintain serum within normal range; and related aspects.

The application discloses an exosome preparation for treating hypofunction of ovary and a preparation method and application thereof, and belongs to the technical field of biological medicine, and particularly relates to a preparation method of an exosome preparation for treating hypofunction of ovary, which comprises the following steps: taking perinatal stem cells, subculturing, obtaining domesticated perinatal stem cells, digesting, expanding and culturing to a density of 80%-85%, adding a culture medium for culturing, collecting supernatant, collecting supernatant for 3 times, combining, filtering through a 0.45 mu m PES filter membrane first, and then concentrating to obtain a concentrated solution; centrifuging, resuspending a precipitate, purifying through a density gradient, obtaining an exosome precipitate, and suspending the exosome precipitate in a cryopreservation protective solution to obtain the exosome preparation. The application provides the exosome preparation for treating hypofunction of ovary and the preparation method and application thereof, a safe, sufficient, high-purity and stable exosome preparation is prepared, and the stem cell exosome for treating hypofunction of ovary is provided.

This invention provides a mouse model of hypothyroidism combined with pulmonary hypertension, its construction method, and its application, belonging to the field of animal experimental model construction technology. In this invention, a hypothyroid mouse model was obtained by intragastric administration of methimazole and feeding mice under normoxic conditions. The hypothyroid mouse model was then further modified by intragastric administration of methimazole, followed by continuous subcutaneous injection of the vascular endothelial growth factor inhibitor Su5416, and feeding the mice under hypoxic conditions to obtain a mouse model of hypothyroidism combined with pulmonary hypertension. This invention successfully established a stable mouse model of hypothyroidism combined with pulmonary hypertension through a combination of drug intervention and hypoxic feeding.

The invention provides an application of a methoxy isoflavone compound in prevention and treatment of premature ovarian failure. A large number of studies find that the biochanin A and formononetin can effectively improve ovarian reserve function decline or estrus cycle disorder caused by premature senility, adjust the estrogen level, promote follicle development and maturity, increase the ovarian index, increase ovarian reserve and recover the ovarian function. Meanwhile, the biochanin A and the formononetin have the advantages of good stability, high biological activity and low toxicity, can be safely used for preparing medicines for preventing or / and treating ovarian reserve hypofunction and premature senility, and have good patent medicine prospects.

A detector system for non-invasively detecting exacerbation of heart hypofunction comprises a sensor (102) configured to produce a measurement signal when being in a movement sensing relation with a jugular vein (105) of an individual. The detector system comprises a processing system (101) configured to receive the measurement signal, and a memory system (103) communicatively connected to the processing system. As changes in high frequency oscillations in jugular vein pressure can be indicative of development of heart hypofunction, the processing system is configured to compare first data stored in the memory system and based on an earlier produced measurement signal to second data based on a later produced measurement signal, and to form indicator data indicative of exacerbation of heart hypofunction based on the comparison between the first data and the second data.

Materials and methods of treating a patient with type 2 diabetes mellitus, metabolic syndrome, obesity, infertility, high blood pressure, hyperthyroidism, and hypothyroidism, hyperlipidaemia, osteoporosis, osteoarthritis, hypoadrenalism, polycystic ovary syndrome, or Parkinson's disease comprising administering a therapeutically effective amount of ex vivo cultured activated peripheral blood mononuclear cells (PBMCs) to the patient. The ex vivo cultured activated cells are activated and cultured in a presence of a cytokine and may be autologous or allogeneic relative to the patient.

This disclosure relates to compositions and methods for treating hypothyroidism. Wherein a method of treating a patient for hypothyroidism, comprises: a) obtaining a sample from a patient containing DNA; b) determining a number of pre-defined single nucleotide polymorphisms (SNPs) contained in the DNA of the sample; c) administering to the patient a therapeutically effective amount of levothyroxine.

The invention is directed to a hypoadrenocorticism diagnostic tool including a computer device for executing a trained machine learning algorithm to analyze bloodwork parameters and determine a hypoadrenocorticism diagnosis based on the bloodwork parameters. The bloodwork parameters may include complete blood count and serum chemistry parameters. The computer device receives the bloodwork parameters associated with a patient and analyzes the bloodwork parameters using the trained machine learning algorithm. The computer device determines the hypoadrenocorticism diagnosis indicating whether the patient is positive or negative for hypoadrenocorticism using the trained machine learning algorithm, and displays the hypoadrenocorticism diagnosis on a graphical user interface.

The invention belongs to the technical field of animal experiment model construction, and particularly relates to a construction method of a hypothyroidism and depression combined mouse model. Comprising the following steps: giving drinking water containing methimazole to a mouse, detecting the serum TSH level every two weeks, carrying out synchronous behavioral evaluation, and determining a modeling end point according to continuous increase of TSH and stable occurrence of depression behaviors so as to obtain the mouse model with hypothyroidism and depression. Through three innovations of methimazole free drinking water administration, double-week TSH-behavioral dynamic monitoring and eight-week multi-index end point verification, a mouse model with thyroid degeneration and depression combined with thyroid degeneration and depression, which can be operated in a standardized manner and has traceable pathology, is established for the first time, and the problems of tissue damage, complicated operation, rough monitoring and model deficiency in the prior art are solved; and an irreplaceable platform tool is provided for co-disease research and drug development.

The present application relates to the use of a PTH compound for the treatment of chronic parathyroidism wherein said treatment comprises the step of administering a weekly dose of a PTH compound per week to a patient suffering from chronic parathyroidism, and wherein before the start of the treatment, the PTH compound is added to the patient. Patients are clinically determined to no longer rely on active vitamin D and calcium supplements to maintain serum within a normal range; and related aspects.