8 results about "Hypofunctions" patented technology

The present invention relates to methods of treating hypogonadism in a male subject through administering intranasally to the male subject an intranasal testosterone bio-adhesive gel formulation to deliver a therapeutically effective amount of testosterone. In particular, the testosterone therapy of the invention remains effective if an allergic rhinitis event occurs in the male during the treatment or when the male subject uses a topical nasal vasoconstrictor or a topical intranasal decongestant during the hypogonadism treatment. Further, the present invention relates to a method of preventing Hie occurrence of an allergic rhinitis event in a male, who is undergoing a hypogonadism treatment with an intranasal testosterone bio-adhesive gel. In certain embodiments, the intranasal testosterone bio-adhesive gel formulation according to the invention comprises 4.0% and 4.5% testosterone.

Disclosed are a compound that is a parathyroid hormone receptor 1 agonist and a method useful for preventing or treating osteoporosis, fractures, osteomalacia, arthritis, thrombocytopenia, hypoparathyroidism, hyperphosphatemia, or neoplastic calcification.

The present invention relates to a PTH compound for use in the treatment of chronic hypoparathyroidism, wherein the treatment comprises the step of administering to a patient having chronic hypoparathyroidism a once weekly dose of a PTH compound and wherein prior to initiation of the treatment the patient is clinically determined as being no longer dependent on active vitamin D and calcium supplement to maintain serum within normal range; and related aspects.

The application discloses an exosome preparation for treating hypofunction of ovary and a preparation method and application thereof, and belongs to the technical field of biological medicine, and particularly relates to a preparation method of an exosome preparation for treating hypofunction of ovary, which comprises the following steps: taking perinatal stem cells, subculturing, obtaining domesticated perinatal stem cells, digesting, expanding and culturing to a density of 80%-85%, adding a culture medium for culturing, collecting supernatant, collecting supernatant for 3 times, combining, filtering through a 0.45 mu m PES filter membrane first, and then concentrating to obtain a concentrated solution; centrifuging, resuspending a precipitate, purifying through a density gradient, obtaining an exosome precipitate, and suspending the exosome precipitate in a cryopreservation protective solution to obtain the exosome preparation. The application provides the exosome preparation for treating hypofunction of ovary and the preparation method and application thereof, a safe, sufficient, high-purity and stable exosome preparation is prepared, and the stem cell exosome for treating hypofunction of ovary is provided.

This invention provides a mouse model of hypothyroidism combined with pulmonary hypertension, its construction method, and its application, belonging to the field of animal experimental model construction technology. In this invention, a hypothyroid mouse model was obtained by intragastric administration of methimazole and feeding mice under normoxic conditions. The hypothyroid mouse model was then further modified by intragastric administration of methimazole, followed by continuous subcutaneous injection of the vascular endothelial growth factor inhibitor Su5416, and feeding the mice under hypoxic conditions to obtain a mouse model of hypothyroidism combined with pulmonary hypertension. This invention successfully established a stable mouse model of hypothyroidism combined with pulmonary hypertension through a combination of drug intervention and hypoxic feeding.

The invention provides an application of a methoxy isoflavone compound in prevention and treatment of premature ovarian failure. A large number of studies find that the biochanin A and formononetin can effectively improve ovarian reserve function decline or estrus cycle disorder caused by premature senility, adjust the estrogen level, promote follicle development and maturity, increase the ovarian index, increase ovarian reserve and recover the ovarian function. Meanwhile, the biochanin A and the formononetin have the advantages of good stability, high biological activity and low toxicity, can be safely used for preparing medicines for preventing or / and treating ovarian reserve hypofunction and premature senility, and have good patent medicine prospects.

Materials and methods of treating a patient with type 2 diabetes mellitus, metabolic syndrome, obesity, infertility, high blood pressure, hyperthyroidism, and hypothyroidism, hyperlipidaemia, osteoporosis, osteoarthritis, hypoadrenalism, polycystic ovary syndrome, or Parkinson's disease comprising administering a therapeutically effective amount of ex vivo cultured activated peripheral blood mononuclear cells (PBMCs) to the patient. The ex vivo cultured activated cells are activated and cultured in a presence of a cytokine and may be autologous or allogeneic relative to the patient.