47 results about "Pituitary tumors" patented technology

The invention relates to a Chinese medicine composition for treating pituitary tumor, which is prepared from the following bulk pharmaceutical chemicals in parts by weight: 15-25 parts of arisacma consanguineum, 10-20 parts of seaweed, 25-35 parts of raw oyster, 4-14 parts of ginger processed pinellia, 7-17 parts of rhizoma sparganii, 10-20 parts of salvia chinensis, 7-17 parts of poria cocos and25-35 parts of raw astragalus mongholicus. The invention also provides an application of the Chinese medicine composition. The Chinese medicine composition has the advantages that the compatibility of the Chinese medicine composition conforms to the assistant and guide principle of the traditional Chinese medicine. The clinical test proves that the Chinese medicine composition disclosed by the invention has obvious curative effect advantages, and has good curative effect on eliminating pituitary tumor, lowering the postoperative recurrence rate and reducing side effect after the western medicine is taken. The Chinese medicine composition also has good curative effect, no obvious toxic or side effect, no adverse reaction and wide clinic application prospect.

To provide a pharmaceutical agent or an antitumor agent useful for the treatment and / or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1):(wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The invention relates to novel application of a transcription factor FOXD1, in particular to application of the transcription factor FOXD1 in regulating pituitary tumor disease. On the basis of a gene chip method, 10 pituitary tumor case samples and 5 normal comparison samples are sequenced, and a backup gene is screened. In addition, QPCR verification and siRNA interference experiment are performed, results show that the FOXD1 is highly related to pituitary tumor, and proliferation of pituitary tumor cells is slowed down by interfering FOXD 1 gene expression. The results provide a novel idea for clinical diagnosis and novel treatment of the pituitary tumor.

The method relates to novel application of PAK3 as a biological marker of a neuroendocrine tumor. Through protein expression level detection of PAK3 on thymic carcinoid, pheochromocytoma, parathyroid adenoma, pituitary tumor, adrenal adenoma, cell strains of islet cell tumor, cell strains of small cell lung cancer and other neuroendocrine tumor tissues and cells, the PAK3 highly expresses and covers neuroendocrine tumors common in clinics and relates to each tissue and gland of body; the novel application initially finds that the PAK3 is relevant to tumors, in particular to the neuroendocrine tumor; the novel application discloses that the PAK3 can obviously increase the transferring capacity of the cell and shows that the PAK3 plays an important role in the developing process of the neuroendocrine tumor; and the result shows that the PAK3 can be used as the biological marker of the neuroendocrine tumor.

The invention discloses a novel isoquinoline compound, and a synthetic method thereof as well as an application of the compound, which is used as an agonist or an inhibitor of dopamine receptors in the medicines for treating Parkinson's disease, schizophrenia, tristimania, Tourette syndrome, attention-deficit hyperkinetic syndrome, pituitary tumor, etc. The constitutional formula of the compound is as follows: wherein, R1 is the hydrocarbyl with a H, C1-C10 linear chain or fork chain, heteroatom-substituted hydrocarbyl and aromatic or fatty heterocycle or non-heterocycle substituted alkyl; X is carbonyl, methylene and imidogen, and is more than C-OH or more than C=; Y is carboxide, methylene and imidogen, and is more than C= or more than C=N-OH; the compound can have no D cycle or the D cycle can be various heterocycles of substituted five-membered fat and substituted six-membered fat or substituted five-membered aromatic and six-membered aromatic; n is 0-3.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e,g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea sydrome, multilocular ovary sydrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention relates to a transsphenoidal pituitary tumor locating device based on ultrasonic blood flow detection guidance. The device consists of a phased array ultrasonic Doppler transducer and anultrasonic main machine, wherein the ultrasonic main machine comprises a central control processing unit, a transmitting / receiving circuit module and a graphic display module, and the ultrasonic Doppler transducer comprises a piezoelectric unit, a transmitting amplifier and a receiving amplifier. The device adopts a phased array technology for carrying out different time delay processing on signals input and output by an array in the transducer. By calculating and obtaining information such as the tissue distance, the blood vessel depth and the Doppler frequency shift amount at the detectionposition and displaying the information in the form of images, the transducer does not need to be rotated mechanically, the blood vessel detection efficiency is improved, and accidental injuries possibly caused in an operation process are avoided.

The invention discloses a traditional Chinese medicine preparation for pituitary tumor surgery postoperative nursing. The traditional Chinese medicine preparation is prepared from the following components according to a certain weight ratio: semen lepidii, rhizoma imperatae, rhizoma sparganii, curcuma rhizome, oriental waterplantain rhizome, polyporus, prepared pinellia tuber, rhizoma typhonii, arisaema cum bile, curcuma tuber, fried peach seed, safflower, pangolin, white peony root, ligusticum wallichii, pseudo-ginseng, rhizoma acori graminei, oldenlandia, barbat skullcap, ground beetle, scorpion, red sage root, poria cocos, Japanese eupatorium, bushy sophora root, trumpet creeper flower, and muscardine silkworm. The traditional Chinese medicine preparation can be mixed with a proper amount of vinegar, and then pasted on the affected parts. The traditional Chinese medicine preparation has the functions of clearing heat, inducing diuresis, clearing damp, promoting diuresis, dissolving lumps, resolving stasis, and removing toxicity. The preparation method is unique and the nursing effect is prominent.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc. or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The embodiments of the application discloses a pituitary tumor image classification method, a pituitary tumor image classification system and electronic equipment. The method comprises the following steps: acquiring a magnetic resonance image of a brain to be classified; inputting the magnetic resonance image of the brain to be classified into a classification model, wherein the classification model is an artificial neural network comprising an attention module, and the classification model is obtained after training by taking the extracted magnetic resonance images form the area where the pituitary tumor is located as a first training sample; extracting image features in the magnetic resonance image of the brain through the classification model, determining the importance degree of each image feature in the the magnetic resonance image of the brain through the attention module, and obtaining a classification result corresponding to the magnetic resonance image of the brain based on the importance degree of each image feature. By implementing the embodiment of the invention, the importance degree of the image feature can be determined through the attention module according to the contribution of each image feature to the classification task, so that the classification accuracy is improved.

The invention discloses a gene MUC21 and application of an expression product of the gene MUC21 in hypophysoma diagnosis and treatment.The gene MUC21 related to generation and development of hypophysoma is screened through a bioinformatics method, function verification is conducted through a fluorescent quantitative method and the like, and down-regulated expression of the gene MUC21 is conducted in hypophysoma patient tissue; by increasing the expression of the gene MUC21, the excessive proliferation of hypophysoma cells can be restrained.The invention further discloses a product for diagnosing hypophysoma and a medicine composition for treating hypophysoma.

The invention discloses a pituitary tumor texture image grading method based on fine-grained medical image segmentation and true value discovery data amplification. The pituitary tumor texture image grading method comprises the following steps: 1, optimizing fruit fly-density peak clustering medical image segmentation based on fine granularity; 2, amplifying pituitary adenoma data discovered on the basis of true values; and 3, grading based on the pituitary adenoma texture images in the step 1 and the step 2. According to the pituitary tumor texture image grading method, the medical image is accurately segmented through fusion of a fine-grained division algorithm and an FOA-DPC algorithm; medical image data amplification based on a true value discovery theory is also realized, and the problem of few available medical image data sets is solved. The pituitary tumor texture image grading method combines a KFOA-DPC segmentation algorithm with deep learning, so as to solve the problems thatthe gray scale of a dicom format image is numerous and jumbled, and features are not easy to extract, realize classification of pituitary adenoma texture softness and toughness and assist clinical diagnosis.

The invention belongs to the field of biotechnology and microbe and animal cell lines and specifically relates to a humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH, especially to a first international humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH and its establishment method and application. Through isolated culture of pituitary tumor cells from a patient with clinical drug-resistant GH-type pituitary tumor, the humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH is obtained. The cell strain is passaged for 50 times for the first time and is mostly round or elliptical, cytoplasm is abundant, and nucleus is large and round. It shows through experimental results that the cell strain can be passaged stably, can secrete growth hormones continuously, is drug-resistant to somatostatin analogue, can be used to provide a necessary cell test tool for researches on pathogenic and drug-resistance mechanisms of pituitary tumor, research and development and screening of new drugs and new biotherapy and detection of related bio-engineering products and the like, and has exploring potential and application value.

The invention relates to a filter collector for pituitary tumor surgical specimens. The filter collector for pituitary tumor surgical specimens comprises a suction tube (2) and a negative pressure suction tube (3). One end of the suction tube (2) is provided with a suction hose (4) used to suck specimen tissues. The other end of the suction tube (2) is provided with a connector. The connector is connected with a filter tube (1). A filter (5) is arranged inside the filter tube (1). The other end of the filer tube (1) matches with a connection of the negative pressure suction tube (3) in shape and is disposed on the connection of the negative pressure suction tube (3). The filter collector enables collection of tumor specimens for brain tumor surgery to be convenient collection to be faster, and acquisition of large specimen tissues to be easy, so that accuracy in laboratory test results is increased and related fundamental research is facilitated.

The invention discloses a compound preparation for treating hyperprolactinemia and a preparation method thereof .The compound preparation is prepared from tamoxifen, letrozole, estradiol valerate, clomifene citrate, human chorionic gonadotropin, progesterone, bromocriptine, levodopa, octahydro benzoquinoline, vitamin B6, ginsenoside Rh2, fucoidan from fucus vesiculosus and paclitaxel .The compound preparation can effectively inhibit the production of pituitary tumor cells and thus inhibit the secretion and synthesis of prolactin of pituitary tumor cells, can effectively reduce the prolactin content in blood of patients with the hyperprolactinemia, the hypothalamus pituitary gonadal axis of the patients can play a good regulating role at all levels, and a feasible method having a wider prospect is provided for effective treatment of the hyperprolactinemia.

The invention provides a traditional Chinese medicine composition for treating intracranial tumors. The traditional Chinese medicine composition comprises more than thirty Chinese herbal medicines including centipede, scorpion, longnosed pit viper, dahurian angelica root, Siberian cocklour fruit, biond magnolia flower bud, tall gastrodia tuber, lucid ganoderma, Chinese caterpillar fungus and the like. The traditional Chinese medicine composition has the effects of detoxifying and inducing resuscitation, resolving phlegm and alleviating mental depression, eliminating swelling and softening hard masses, nourishing the liver and kidneys and the like, and adopts simultaneous elimination and reinforcement for treating intracranial tumors. The traditional Chinese medicine provided by the invention has significant curative effects on intracranial benign and malignant tumors including various types of gliomata, pituitary tumors, meningioma, craniopharyngioma, pinealoma, cavernous tubercule, neurilemmoma, chordoma, metastatic encephaloma and the like, and can enable tumor cells to loss reproductive capacity so as to ensure that tumor bodies are gradually reduced, calcified or disappeared.

The invention discloses a 2-amino-4-indolyl pyrimidine compound as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. In particular to pyrimidine compounds, stereoisomers or pharmaceutically acceptable salts thereof, preparation methods of the pyrimidine compounds and the stereoisomers or the pharmaceutically acceptable salts thereof, and application of the pyrimidine compounds and the stereoisomers or the pharmaceutically acceptable salts in antitumor drugs. Pharmacological experiment results show that the compound can inhibit proliferation of various tumor cells, and the cancer or tumor related diseases comprise various solid tumors and hematoma such as brain glioma, pituitary tumor, glioma, melanoma, breast cancer, lung cancer, stomach cancer, ovarian cancer, colon cancer, liver cancer, pancreatic cancer, prostate cancer, testicular cancer, multiple myeloma, leukemia and the like. The compound provided by the invention is expected to be developed into a new generation of anticancer drugs.

The invention discloses a method for grading pituitary tumor texture images based on fine-grained medical image segmentation and true value discovery data amplification, comprising the following steps: Step 1: medical image segmentation based on fine-grained optimization of Drosophila-density peak clustering; Step 2: Amplification of pituitary tumor data based on true value discovery; Step 3: Grading of pituitary tumor texture images based on Step 1 and Step 2. The present invention accurately segments medical images through the fusion of fine-grained partitioning algorithm and FOA-DPC algorithm; the present invention also realizes medical image data amplification based on truth discovery theory, and solves the problem of too few available medical image data sets. The invention combines the KFOA‑DPC segmentation algorithm with deep learning to solve the problem of dicom format images with complex gray levels and difficult feature extraction, realize the soft and tough classification of pituitary tumors, and assist clinical diagnosis.

The invention discloses a pituitary tumour cutting and clearing-away device. The pituitary tumour cutting and clearing-away device comprises an external clearing-way machine, a drainage tube and a sucking mechanism, wherein the external clearing-away machine is connected to the drainage tube; a negative-pressure suction machine is started; the drainage tube is used for guiding and draining pituitary tumours into a tumour substance collecting box; a sucking head sucks pituitary tumours; after last-time sucking is finished, the sucking tube is pulled upwards, so that extrusion force, on elastictelescopic plates at two sides, of the sucking tube disappears, the elastic telescopic plates at the two sides are shrunk to be closed in a contact mode, and therefore, the drainage tube is preventedfrom generating reflow to make sucked pituitary tumours flow back, the sucking head is prevented from being exposed in air for a long term to be infected with bacteria, and possibility of bacterial infection in operation is reduced; when the sucking mechanism is used again, the sucking tube is downwards extruded, so that two side walls of the sucking tube cling to the elastic telescopic plates, and the sucking head passes through a tube orifice to suck the pituitary tumours; the sucking head adopts a flat tube body, and the inner cavity of the sucking head is gradually reduced from back to front, and a formed liquid knife is more sharp, so that practicability of the device is improved.

Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTTG), and nucleic acids encode them. Examples are the human and rat PTTG proteins. The nucleic acids may be applied to the production of a recombinant protein, and to the detection of the presence of PTTG genes in different species. The nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences and / or being carried by a host cell. The nucleic acids may also be delivered to a mammal to compensate for the absence, or a defective expression, of endogenous protein. The nucleic acids, proteins, and antibodies are also employed in disgnostic assays, as well as, for example, in the production of anti-PTTG antibodies (protein), therapeutic compositions and other applications of the proteins and antibodies. Various kits utilize nucleic acids, polypeptides, and / or antibodies. A transgenic non-human mammal expresses PTTG.

The invention provides application of long-chain non-coding RNA ST8SIA6-AS1 as a pituitary tumor molecular marker, belongs to the technical field of tumor molecular biology, and particularly relates to application of the long-chain non-coding RNA ST8SIA6-AS1 as the pituitary tumor molecular marker. The application comprises the application of the detection reagent of the long-chain non-coding RNA ST8SIA6-AS1 in preparation of a pituitary tumor diagnosis and prognosis detection kit. The invention further discloses application of the inhibitor of the long-chain non-coding RNA ST8SIA6-AS1 or the inhibitor of the long-chain non-coding RNA ST8SIA6-AS1 in preparation of medicines for treating Wherein the nucleotide sequence of the long-chain non-coding RNA ST8SIA6-AS1 is as shown in SEQ ID NO.1. According to the invention, a potential therapeutic target is provided for pituitary tumors.

The invention provides a biomarker method for identifying the existence form of human pituitary tissue lactation hormone protein. The method comprises the following steps of collecting pituitary adenoma and normal pituitary tissue samples, respectively extracting the tissue proteins, scanning a visual PVDF membrane and bidirectional gel into a digital image through bidirectional gel electrophoresis and western blot silver staining, digesting and purifying the corresponding two-way gel protein spots, and identifying the difference of the existing form proportions of different pituitary tissue lactation hormone proteins of different pituitary tumor sub-types through mass spectrum identification and bioinformatics analysis. According to the present invention, the existence forms of the human pituitary tissue lactation hormone protein and the differential expression profiles of the prolactin proteins in different pituitary tumors are identified, so that the development of drugs for blocking prolactin signal channels for clinical treatment is facilitated.

The invention discloses a pituitary tumor operation planning system based on an artificial intelligence technology. The system comprises the following steps: 1, acquiring a vascular medical image sequence, a skeleton medical image sequence and a pituitary tumor medical image sequence; 2, if the medical image sequences are the image sequences shot at different moments or the image sequences shot at the same moment are not in the same coordinate system, performing registration, and placing the image sequences in the same coordinate system; 3, using a deep neural network model to take each medical image sequence in the same coordinate system as input, and outputting a blood vessel image segmentation result, a skeleton image segmentation result and a pituitary tumor image segmentation result; and 4, performing three-dimensional reconstruction on the blood vessel image segmentation result, the skeleton image segmentation result and the pituitary tumor image segmentation result to obtain a three-dimensional model for pituitary tumor preoperative planning. The method is high in processing speed and high in reliability, so that preoperative evaluation and surgical planning of clinicians become simple, accurate and rapid.