Use of hordenine in the preparation of medicines for treating pituitary tumors

A technology for hordenine and pituitary tumor, which is applied in the application field of hordenine in the preparation of drugs for the treatment of pituitary tumors, can solve the problems of incompletely clear pathogenesis of Cushing's disease, high mortality rate, poor prognosis of patients with recurrence, etc. The effect of addressing drug shortages

Active Publication Date: 2021-08-24
王雄 +1
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  • Abstract
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Problems solved by technology

Although the literature reports that the success rate of surgery is 65%-90%, due to the difference in the biological behavior of the tumor itself and the difference in the operation level of the surgeon, the tumor recurrence rate is 3%-47%, and the average recurrence time is 16-49 months , the prognosis of relapsed patients is poor and the mortality rate is high
In recent years, the research on the molecular level of Cushing's disease has mainly focused on the occurrence and development of tumors, the aggressiveness of tumors and hormone secretion, etc., but the pathogenesis of Cushing's disease is still not completely clear

Method used

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  • Use of hordenine in the preparation of medicines for treating pituitary tumors
  • Use of hordenine in the preparation of medicines for treating pituitary tumors
  • Use of hordenine in the preparation of medicines for treating pituitary tumors

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Experimental program
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Embodiment 1

[0063] 1. Establishment of tumor model

[0064] 1.1. Establishment of a prolactinoma model in rats.

[0065] Rat strains used in the rat pituitary prolactinoma model mainly include Fischer344 (F344) [34] rats, wistar-furth (Wister) rats, SD rats, etc. The inventors have found through experimental research that compared with Wister rats and SD rats, F344 rats are more sensitive, and the induced prolactinoma model has a shorter tumor formation time, and the tumor formation rate is as high as 100%. The operation is simple and easy, and No tumor metastasis or associated tumors will occur, and it is an ideal animal model for studying pituitary prolactinoma.

[0066] 80 F344 rats were randomly divided into normal group and model group, and rats in other groups except the normal group were made as prolactinoma models.

[0067] The model group needs to undergo ovariectomy first: the rats are anesthetized, placed on the fixed table in the abdominal position, the long hair is cut off ...

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Abstract

The invention discloses the use of hordenine in the preparation of drugs for treating pituitary tumors, and relates to the technical field of biopharmaceuticals. Specifically, in this application, the inventors have discovered that hordenine can inhibit TLR4 / NF-κB / The MAPK signaling pathway helps to treat prolactinoma and adrenocorticotropic adenoma to play a drug effect, and solves the plight of drug shortage for patients with prolactinoma and adrenocorticotropic adenoma.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to the application of hordenine in the preparation of medicines for treating pituitary tumors. Background technique [0002] Pituitary tumor is one of the common benign intracranial tumors. Its incidence rate is second only to glioma and meningioma in intracranial tumors, accounting for about 10% of intracranial tumors. The rate has been increasing year by year. As the tumor continues to grow, it can compress the surrounding structures of the sella region, such as the optic nerve, cavernous sinus, base of the brain artery, hypothalamus, etc., and even involve the frontal lobe and brainstem, resulting in severe dysfunction. At the same time, tumor growth can also lead to disorders of pituitary hormone secretion. According to peripheral blood hormone levels, pituitary adenomas are divided into non-functioning pituitary adenomas (NFPA) and functional pituitary adenomas, in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61P35/00
CPCA61K31/137A61P35/00
Inventor 王雄吴金虎
Owner 王雄
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