32 results about "Pituitary tumours" patented technology

The invention relates to a Chinese medicine composition for treating pituitary tumor, which is prepared from the following bulk pharmaceutical chemicals in parts by weight: 15-25 parts of arisacma consanguineum, 10-20 parts of seaweed, 25-35 parts of raw oyster, 4-14 parts of ginger processed pinellia, 7-17 parts of rhizoma sparganii, 10-20 parts of salvia chinensis, 7-17 parts of poria cocos and25-35 parts of raw astragalus mongholicus. The invention also provides an application of the Chinese medicine composition. The Chinese medicine composition has the advantages that the compatibility of the Chinese medicine composition conforms to the assistant and guide principle of the traditional Chinese medicine. The clinical test proves that the Chinese medicine composition disclosed by the invention has obvious curative effect advantages, and has good curative effect on eliminating pituitary tumor, lowering the postoperative recurrence rate and reducing side effect after the western medicine is taken. The Chinese medicine composition also has good curative effect, no obvious toxic or side effect, no adverse reaction and wide clinic application prospect.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc. or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The embodiments of the application discloses a pituitary tumor image classification method, a pituitary tumor image classification system and electronic equipment. The method comprises the following steps: acquiring a magnetic resonance image of a brain to be classified; inputting the magnetic resonance image of the brain to be classified into a classification model, wherein the classification model is an artificial neural network comprising an attention module, and the classification model is obtained after training by taking the extracted magnetic resonance images form the area where the pituitary tumor is located as a first training sample; extracting image features in the magnetic resonance image of the brain through the classification model, determining the importance degree of each image feature in the the magnetic resonance image of the brain through the attention module, and obtaining a classification result corresponding to the magnetic resonance image of the brain based on the importance degree of each image feature. By implementing the embodiment of the invention, the importance degree of the image feature can be determined through the attention module according to the contribution of each image feature to the classification task, so that the classification accuracy is improved.

The invention discloses a novel acromegaly screening system and a screening method thereof. The system comprises a pituitary adenoma intelligent health management platform, a hand feature database andan artificial intelligence early screening system; the pituitary adenoma intelligent health management platform is used for collecting hand photos of a to-be-tested person. the pituitary adenoma intelligent health management platform stores the collected hand photos in a hand feature database; the artificial intelligence early screening system comprises a convolutional neural network; the convolutional neural network carries out artificial intelligence deep learning on the hand photos in the hand feature database, so that a deep learning model is established, operation is carried out, and repeated verification and correction and data classification are carried out; and the artificial intelligence early screening system performs artificial intelligence background measurement and calculation on the hand photos, then outputs screening data, and preliminarily determines whether the patient is acromegaly patient or not according to the screening data; The novel acromegaly screening systemis low in cost and high in efficiency, replaces hematology / nuclear magnetic resonance examination and the like, and effectively reduces investment of manpower and material resources for screening.

The invention discloses a pituitary tumor texture image grading method based on fine-grained medical image segmentation and true value discovery data amplification. The pituitary tumor texture image grading method comprises the following steps: 1, optimizing fruit fly-density peak clustering medical image segmentation based on fine granularity; 2, amplifying pituitary adenoma data discovered on the basis of true values; and 3, grading based on the pituitary adenoma texture images in the step 1 and the step 2. According to the pituitary tumor texture image grading method, the medical image is accurately segmented through fusion of a fine-grained division algorithm and an FOA-DPC algorithm; medical image data amplification based on a true value discovery theory is also realized, and the problem of few available medical image data sets is solved. The pituitary tumor texture image grading method combines a KFOA-DPC segmentation algorithm with deep learning, so as to solve the problems thatthe gray scale of a dicom format image is numerous and jumbled, and features are not easy to extract, realize classification of pituitary adenoma texture softness and toughness and assist clinical diagnosis.

The invention belongs to the field of biotechnology and microbe and animal cell lines and specifically relates to a humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH, especially to a first international humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH and its establishment method and application. Through isolated culture of pituitary tumor cells from a patient with clinical drug-resistant GH-type pituitary tumor, the humanized drug-resistant GH-type pituitary tumor cell strain huashanc-CH is obtained. The cell strain is passaged for 50 times for the first time and is mostly round or elliptical, cytoplasm is abundant, and nucleus is large and round. It shows through experimental results that the cell strain can be passaged stably, can secrete growth hormones continuously, is drug-resistant to somatostatin analogue, can be used to provide a necessary cell test tool for researches on pathogenic and drug-resistance mechanisms of pituitary tumor, research and development and screening of new drugs and new biotherapy and detection of related bio-engineering products and the like, and has exploring potential and application value.

The invention discloses an application of miRNA-424 as a diagnostic marker of pituitary adenoma and preparation or screening of drugs for treating pituitary adenoma. The invention discovers for the first time that the expression level of miRNA-424 is related to the occurrence of pituitary adenoma. By detecting the expression level of miRNA-424 in a patient, whether the subject has the risk of pituitary adenoma can be judged, thereby guiding the clinician to provide a prevention scheme or a treatment scheme for the subject.

The invention relates to a dopamine D2 receptor selective agonist and application thereof. Specifically, the invention discloses an agonist with selectivity to DRD2 and discloses a potential application value of the agonist in disease treatment. The invention discloses an agonist with DRD2 selectivity for the first time, and the specific targeting DRD2 of the agonist can play a role in treating low dopamine related diseases such as Parkinson's disease, attention deficit hyperactivity disorder, pituitary adenoma, hyperprolactinemia, hyperactivity leg syndrome, negative schizophrenia and the like while side effects are reduced to the maximum extent.

The invention discloses a conchoscope for a transsphenoidal pituitectomy, which comprises a conchoscope body and an eye lens, wherein the conchoscope body comprises a protection tube, an image transmission system and an image adjusting knob; the image transmission system is arranged in the protection tube; the eye lens is arranged at the front end of the protection tube and connected with the image transmission system; the image adjusting knob is arranged at the rear part of the conchoscope body; a suction hole and a connecting port are formed in the protection tube; the suction hole is located above the eye lens; the connecting port is located near the image adjusting knob; a slim tube is arranged in the protection tube and near a tube wall; the slim tube is communicated with the suction hole and the connecting port; the connecting port is connected with an electric negative pressure suction device; and a suction control button is further arranged at the connecting port.Compared with the prior art, the conchoscope can timely clear away smoke and blood caused intraoperatively, ensures a good operation environment, allows an operator to be proficient operationally, ensures effective conduction of an operation, is reasonable in structural design, and safe and reliable in performance, and facilitates improving an operation effect.

The invention discloses a 2-amino-4-indolyl pyrimidine compound as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. In particular to pyrimidine compounds, stereoisomers or pharmaceutically acceptable salts thereof, preparation methods of the pyrimidine compounds and the stereoisomers or the pharmaceutically acceptable salts thereof, and application of the pyrimidine compounds and the stereoisomers or the pharmaceutically acceptable salts in antitumor drugs. Pharmacological experiment results show that the compound can inhibit proliferation of various tumor cells, and the cancer or tumor related diseases comprise various solid tumors and hematoma such as brain glioma, pituitary tumor, glioma, melanoma, breast cancer, lung cancer, stomach cancer, ovarian cancer, colon cancer, liver cancer, pancreatic cancer, prostate cancer, testicular cancer, multiple myeloma, leukemia and the like. The compound provided by the invention is expected to be developed into a new generation of anticancer drugs.

The invention discloses a method for grading pituitary tumor texture images based on fine-grained medical image segmentation and true value discovery data amplification, comprising the following steps: Step 1: medical image segmentation based on fine-grained optimization of Drosophila-density peak clustering; Step 2: Amplification of pituitary tumor data based on true value discovery; Step 3: Grading of pituitary tumor texture images based on Step 1 and Step 2. The present invention accurately segments medical images through the fusion of fine-grained partitioning algorithm and FOA-DPC algorithm; the present invention also realizes medical image data amplification based on truth discovery theory, and solves the problem of too few available medical image data sets. The invention combines the KFOA‑DPC segmentation algorithm with deep learning to solve the problem of dicom format images with complex gray levels and difficult feature extraction, realize the soft and tough classification of pituitary tumors, and assist clinical diagnosis.

The invention discloses a pituitary tumour cutting and clearing-away device. The pituitary tumour cutting and clearing-away device comprises an external clearing-way machine, a drainage tube and a sucking mechanism, wherein the external clearing-away machine is connected to the drainage tube; a negative-pressure suction machine is started; the drainage tube is used for guiding and draining pituitary tumours into a tumour substance collecting box; a sucking head sucks pituitary tumours; after last-time sucking is finished, the sucking tube is pulled upwards, so that extrusion force, on elastictelescopic plates at two sides, of the sucking tube disappears, the elastic telescopic plates at the two sides are shrunk to be closed in a contact mode, and therefore, the drainage tube is preventedfrom generating reflow to make sucked pituitary tumours flow back, the sucking head is prevented from being exposed in air for a long term to be infected with bacteria, and possibility of bacterial infection in operation is reduced; when the sucking mechanism is used again, the sucking tube is downwards extruded, so that two side walls of the sucking tube cling to the elastic telescopic plates, and the sucking head passes through a tube orifice to suck the pituitary tumours; the sucking head adopts a flat tube body, and the inner cavity of the sucking head is gradually reduced from back to front, and a formed liquid knife is more sharp, so that practicability of the device is improved.

The invention provides application of long-chain non-coding RNA ST8SIA6-AS1 as a pituitary tumor molecular marker, belongs to the technical field of tumor molecular biology, and particularly relates to application of the long-chain non-coding RNA ST8SIA6-AS1 as the pituitary tumor molecular marker. The application comprises the application of the detection reagent of the long-chain non-coding RNA ST8SIA6-AS1 in preparation of a pituitary tumor diagnosis and prognosis detection kit. The invention further discloses application of the inhibitor of the long-chain non-coding RNA ST8SIA6-AS1 or the inhibitor of the long-chain non-coding RNA ST8SIA6-AS1 in preparation of medicines for treating Wherein the nucleotide sequence of the long-chain non-coding RNA ST8SIA6-AS1 is as shown in SEQ ID NO.1. According to the invention, a potential therapeutic target is provided for pituitary tumors.

The invention provides a biomarker method for identifying the existence form of human pituitary tissue lactation hormone protein. The method comprises the following steps of collecting pituitary adenoma and normal pituitary tissue samples, respectively extracting the tissue proteins, scanning a visual PVDF membrane and bidirectional gel into a digital image through bidirectional gel electrophoresis and western blot silver staining, digesting and purifying the corresponding two-way gel protein spots, and identifying the difference of the existing form proportions of different pituitary tissue lactation hormone proteins of different pituitary tumor sub-types through mass spectrum identification and bioinformatics analysis. According to the present invention, the existence forms of the human pituitary tissue lactation hormone protein and the differential expression profiles of the prolactin proteins in different pituitary tumors are identified, so that the development of drugs for blocking prolactin signal channels for clinical treatment is facilitated.

The invention provides a non-functional pituitary adenoma detection device and its application. The device of the present invention performs Massarray SNP typing detection on the single nucleotide polymorphism site rs2981582 of the sample to be tested. This site has a significant correlation with the pathogenesis of non-functioning pituitary tumors. The different genetic models of this locus can provide a certain basis for the diagnosis of non-functioning pituitary tumors and have high clinical value. The invention can provide a simple and reliable diagnostic method for the early diagnosis of patients with non-functional pituitary tumors.

The invention discloses a pituitary tumor operation planning system based on an artificial intelligence technology. The system comprises the following steps: 1, acquiring a vascular medical image sequence, a skeleton medical image sequence and a pituitary tumor medical image sequence; 2, if the medical image sequences are the image sequences shot at different moments or the image sequences shot at the same moment are not in the same coordinate system, performing registration, and placing the image sequences in the same coordinate system; 3, using a deep neural network model to take each medical image sequence in the same coordinate system as input, and outputting a blood vessel image segmentation result, a skeleton image segmentation result and a pituitary tumor image segmentation result; and 4, performing three-dimensional reconstruction on the blood vessel image segmentation result, the skeleton image segmentation result and the pituitary tumor image segmentation result to obtain a three-dimensional model for pituitary tumor preoperative planning. The method is high in processing speed and high in reliability, so that preoperative evaluation and surgical planning of clinicians become simple, accurate and rapid.

The present invention discloses a pituitary tumor sampling device convenient for separating pituitary tumor. The device comprises a bottom plate, supporting legs, universal wheels, a first supporting rod, a first telescopic rod, a first fixing plate, a bracket, a second supporting rod, a wire winding rod, a chassis, a fixing base, a second telescopic rod, a limiting rod, a third telescopic rod, an instrument tray, a transverse rod, a stabilizing device and the like. The device is reasonable and simple in structure, low in production cost and convenient to mount, the whole device is more convenient to move through the arranged universal wheels, doctors and patients do not need to walk back and forth to take medical instruments through the arranged instrument tray, and the working intensity is reduced; through the arrangement of the first supporting rod, the first telescopic rod, the first fixing plate, the bracket, the second supporting rod and the wire winding rod, a drainage tube needing to be used when the device is used can be wound and placed; and according to the invention, pituitary tumors can be better fixed through the arranged stabilizing device, so that subsequent sampling, cutting and the like are facilitated.

The invention relates to a selective agonist of DRD2 and application thereof in treatment of diseases. Specifically, the invention discloses an agonist with high selectivity to DRD2 for the first time. The structure of the agonist is shown as a formula I. The selective agonist can be used as a medicine for treating diseases related low dopamine, e.g., the Parkinson's disease. Further animal experiments show that the selective agonist can be used for treating the Parkinson's disease, so a new hope is brought to treatment of patients with the Parkinson's disease; with the Parkinson's disease asan example, it is proved that the selective agonist can be used as a medicine for treating other low-dopamine related diseases such as attention deficit hyperactivity disorder, pituitary adenoma, hyperprolactinemia, hyperactivity leg syndrome and negative schizophrenia.

The invention relates to a Chinese medicine composition for treating pituitary tumor, which is prepared from the following bulk pharmaceutical chemicals in parts by weight: 15-25 parts of arisacma consanguineum, 10-20 parts of seaweed, 25-35 parts of raw oyster, 4-14 parts of ginger processed pinellia, 7-17 parts of rhizoma sparganii, 10-20 parts of salvia chinensis, 7-17 parts of poria cocos and 25-35 parts of raw astragalus mongholicus. The invention also provides an application of the Chinese medicine composition. The Chinese medicine composition has the advantages that the compatibility of the Chinese medicine composition conforms to the assistant and guide principle of the traditional Chinese medicine. The clinical test proves that the Chinese medicine composition disclosed by the invention has obvious curative effect advantages, and has good curative effect on eliminating pituitary tumor, lowering the postoperative recurrence rate and reducing side effect after the western medicine is taken. The Chinese medicine composition also has good curative effect, no obvious toxic or side effect, no adverse reaction and wide clinic application prospect.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention relates to a transsphenoidal pituitary tumor locating device based on ultrasonic blood flow detection guidance. The device consists of a phased array ultrasonic Doppler transducer and anultrasonic main machine, wherein the ultrasonic main machine comprises a central control processing unit, a transmitting / receiving circuit module and a graphic display module, and the ultrasonic Doppler transducer comprises a piezoelectric unit, a transmitting amplifier and a receiving amplifier. The device adopts a phased array technology for carrying out different time delay processing on signals input and output by an array in the transducer. By calculating and obtaining information such as the tissue distance, the blood vessel depth and the Doppler frequency shift amount at the detectionposition and displaying the information in the form of images, the transducer does not need to be rotated mechanically, the blood vessel detection efficiency is improved, and accidental injuries possibly caused in an operation process are avoided.

The invention discloses a fibrinogen compound and an application thereof. The fibrinogen compound comprises fibrinogen, prothrombin and eleven neurotrophic factors. The fibrinogen compound can be used for preparing drugs for treating glaucoma, hypophysoma, traumatic optic nerve injury, operation caused optic nerve injury and the like; and when the compound is combined with transplanted cells, the transplanting repair effect can be enhanced.

The invention provides a preparation method of a medicine composition for treating pituitary adenoma. The medicine composition is prepared from curcuma zedoary, kelp, sorpio, fructus gardeniae, herba lysimachiae, pericarpium citri reticulatae and the like. Clinical experiments prove that the medicine composition prepared through the preparation method has the obvious treatment effect advantages and the good treatment effects on eliminating the pituitary adenoma and reducing side effects occurring after western medicine is administrated, the treatment effects are stable, no obvious toxic and side effect or reverse reaction occurs, and a wide clinical application prospect is achieved.

The invention discloses application of a composition in preparing a medicine for treating pituitary adenoma, wherein the composition is prepared from the following medicinal raw materials: arisacma consanguineum, curcuma zedoary, kelp, scorpio, cape jasmine fruit, longhairy antenoron herb, dried orange peel and the like. Clinical tests prove that the composition disclosed by the invention has a significant advantage in curing pituitary adenoma, the composition has good treatment effects on eliminating pituitary adenoma and relieving side effect caused by the administration of Western medicine, and the composition has a stable curative effect; and in addition, the composition is free from remarkable toxic and side effects as well as free from the occurrence of adverse reaction, and the composition is extensive in prospect of clinical application.

The invention provides a medicine composition for treating pituitary tumors. The medicine composition is prepared from drug substances such as rhizoma curcumae, kelp, scorpion, cape jasmine fruit, longhairy antenoron herb, and dried orange peel. Clinical tests prove that the medicine composition has obvious superiority in curative effect, and excellent curative effects in eliminating pituitary tumors and reducing side effects caused by taking of Western medicine, is stable in curative effect, and has neither obvious toxic or / and side effects nor adverse reactions, thereby having a wide clinical application prospect.