Novel application of PAK3 as biological marker of neuroendocrine tumor

Abstract

The method relates to novel application of PAK3 as a biological marker of a neuroendocrine tumor. Through protein expression level detection of PAK3 on thymic carcinoid, pheochromocytoma, parathyroid adenoma, pituitary tumor, adrenal adenoma, cell strains of islet cell tumor, cell strains of small cell lung cancer and other neuroendocrine tumor tissues and cells, the PAK3 highly expresses and covers neuroendocrine tumors common in clinics and relates to each tissue and gland of body; the novel application initially finds that the PAK3 is relevant to tumors, in particular to the neuroendocrine tumor; the novel application discloses that the PAK3 can obviously increase the transferring capacity of the cell and shows that the PAK3 plays an important role in the developing process of the neuroendocrine tumor; and the result shows that the PAK3 can be used as the biological marker of the neuroendocrine tumor.

Description

technical field [0001] The invention relates to a new application of PAK3 as a biological marker of neuroendocrine tumors. Background technique [0002] There are two forms of endocrine cells distributed in the human body. One is that endocrine cells cluster to form endocrine organs, such as the pituitary gland, and the other is that endocrine cells are scattered among other tissue cells to form a diffuse endocrine system. Through immunocytochemical methods and ultrastructural observation, people continue to make new discoveries about the distribution, morphology and function of endocrine cells. In 1968, Pearse observed that some cells that secrete peptide substances in the body have common cytochemical characteristics, that is, they have the ability to take up amine precursors and remove their carboxyl groups to become active amines (amine precursor uptake and decarboxylation) and named them APUD cells , assigning these cells to the APUD system. With the continuous deepen...

AI Technical Summary

Problems solved by technology

[0004] There are many types of neuroendocrine tumors, with different clinical phenotypes, insidious onset, atypical early symptoms, low detection rate of conventional imaging methods, and difficult localization

At present, the main diagnostic methods for such diseases are: laboratory-related hormone measurement, imaging B-ultrasound, CT, MRI, and pathological examination, the method is not specific enough, the early diagnosis is not sensitive, and often delays the timing of treatment

However, there is no report on the relationship between PAK3 and tumorigenesis and metastasis.