10 results about "Mimotope" patented technology

Disclosed herein are mimotopes, engineered protease activatable receptors (PARs), immune cells including said engineered PARs and reporter nucleic acids encoding reporter molecules which can be secreted by said immune cells, and methods of detecting cancer using the same.

Described herein are methods of treating a human child including administering to the human child a compound selected from epigallocatechin gallate (EGCG), or a derivative thereof selected from epicatechin (EC), epigallocatechin (RGC) and epicatechin gallate (ECG), sulforaphane, olive oil, phylloquinone, quercetin, safranal, hydroxtyrosol, menaquinone-4, menaquinone-7, oleocanthal, peptide Ins-1 B9-23 19CAM22R-E, peptide Ins-1 B12-23-19CAM, peptide Ins-1 B12-23 19CAM22R-E, or a combination of any of the foregoing, wherein administration of the treatment is started between birth and six months of age. Also described are methods of treating a pregnant human or a nursing human mother who has recently given birth to an infant. Further described are insulin B chain mimotope peptides.

The application discloses a fengycin mimotope peptide which can be specifically combined with fengycin antibody, and a sensitive and rapid competitive enzyme-linked immunoassay method can be established by using the phage displaying the mimotope peptide or the mimotope peptide. 50 The IC50 is 0.30 ng / mL, and the LOD is 0.02 ng / mL, and the sensitivity of the method is improved by 60 times compared with the sensitivity of a traditional enzyme-linked immunoassay method based on a hapten; the competitive immunoassay method based on the mimotope peptide has good cross reactivity to other common structural analogues.

The disclosure provides for covalent dual-functional inhibitors of peanut allergic reactions where the inhibitors include a targeting moiety comprising a peanut allergen protein epitope or mimotope peptide sequence, a reactive functional group capable of forming a site-directed covalent bond to the amine moiety of a lysine amino acid of an allergen reactive immunoglobulin, and a variable length spacer comprising oligomers of ethylene glycol monomers, amino acids, saccharides, hydrocarbons, fluorinated hydrocarbons, or a combination thereof, wherein the 10 spacer is conjugated by one or more amide bonds to the TM and the FG.

The present invention provides peptides that specifically bind to maternal autoantibodies that are generated in the mother or potential mother against one or more endogenous polypeptide antigens selected from lactate dehydrogenase A (LDH A), lactate dehydrogenase B (LDH B), stress-induced phosphoprotein 1 (STIP1), guanine deaminase (GDA), Y Box Binding Protein 1 (YBX1), collapsin response mediator protein 1 (CRMP1), and collapsin response mediator protein 2 (CRMP2). The peptides described herein are useful for determining a risk of an offspring for developing an autism spectrum disorder (ASD) by detecting the presence of maternal autoantibodies in a biological sample of the mother or potential mother. The peptides or mimotopes thereof can also be administered to the mother or potential mother to block the binding between maternal autoantibodies and their antigens, thereby neutralizing the maternal autoantibodies.

The invention relates to an okadaic acid mimic epitope peptide and application. The amino acid sequence of the okadaic acid mimic epitope peptide is shown as SEQ ID NO: 1, 3, 5, 7, 9, 11, 13 or 15. The mimic epitope peptide can be specifically combined with an okadaic acid antibody, and a sensitive and rapid competitive enzyme-linked immunosorbent assay is established by using the phage for displaying the mimic epitope peptide; according to the method, the IC50 is 0.83 ng / mL, the LOD is 0.21 ng / mL, and the detection range is 0.35 to 1.98 ng / mL; the competitive immunoassay method established on the basis of the mimic epitope peptide provided by the invention is more sensitive than the traditional immunoassay method, has good cross reaction to other marine toxins, avoids the use of toxin antigens, and is green and environment-friendly.

Disclosed are a peptide having CGRP mimotope function and CGRP detection using same. The peptide may have the following sequences: DVGSYTKAPDF, YGPGGSQAVDF, CRARAGIGLDF, and YVAKATGPADF. The peptide of the present invention can be used in a rapid and accurate single-step immunoassay for CGRP detection, and thus can be effectively used for diagnosis and treatment monitoring of migraine patients.

Provided herein are self-assembling peptide amphiphiles (PAs) comprising a bioactive Transforming growth factor beta 1 (TGF-β1) mimetic epitope, high-aspect-ratio nanostructures of PAs displaying a TGF-β1 mimetic epitope, and methods of enhancing cartilage regeneration / repair and / or treatment of osteoarthritis and other musculoskeletal injuries and diseases.

The present disclosure relates generally to compositions and methods for improving the safety of adoptive immune cell therapy, including the use of a depletion tag (e.g., an epitope or a mimotope) that is capable of binding to another molecule (e.g., an antibody) to facilitate the depletion of the engineered immune cells. One class of depletion tags disclosed herein contain an epitope or mimotope derived from a biomarker of a hematologic cancer (e.g., CCR4). A second class of depletion tags disclosed herein contain an epitope or mimotope derived from the same antigen that the engineered receptor binds to (e.g., a DLL3 derived depletion tag for engineered immune cells that bind to DLL3).

Disclosed herein are mimotopes, engineered protease activatable receptors (PARs), immune cells including said engineered PARs and reporter nucleic acids encoding reporter molecules which can be secreted by said immune cells, and methods of detecting cancer using the same.