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Antibacterial nano fiber material and preparation method thereof

A technology of nanofibers and antibacterial agents, applied in the field of nanofibers and their preparation, can solve the problems of unsatisfactory filtration effect of particles carrying pathogenic bacteria, large fiber pore size, etc., and achieve good drug dispersion, ultra-high specific surface area, and filtration good sex effect

Inactive Publication Date: 2009-02-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When traditional non-woven fabrics, cotton yarns and other materials are used as medical fabrics, due to the thicker fabric fiber diameter and larger fiber pore size, the filtering effect on particles carrying pathogenic bacteria is not ideal

Method used

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  • Antibacterial nano fiber material and preparation method thereof
  • Antibacterial nano fiber material and preparation method thereof
  • Antibacterial nano fiber material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 0.05g of tetracycline hydrochloride in 1.0mL of distilled water; dissolve 0.6g of polylactic acid PLA in 10mL of dichloromethane, then add 0.05g of sodium dodecylsulfonate, and disperse it evenly by ultrasonic vibration; mix the above two solutions Mix to obtain a homogeneous water-in-oil (W / O) emulsion.

[0033] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0034] The diameter of the obtained nanofiber is between 200nm and 1600nm, and the fiber membrane can be seen to be light yellow of tetracycline hydrochloride when observed by naked eyes, indicating that tetracycline hydrochloride has been wrapped in it.

Embodiment 2

[0036] Dissolve 0.05g of penicillin in 1.0mL of distilled water; dissolve 0.6g of polylactic acid-caprolactone P(LLA-CL) [50:50] in 10mL of dichloromethane, then add 0.05g of SPAN-80, and ultrasonically shake The dispersion is uniform; the above two solutions are mixed to obtain a uniform W / O emulsion.

[0037] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0038] The diameter of the obtained nanofiber is between 400nm and 1200nm.

Embodiment 3

[0040]Dissolve 0.05g streptomycin in 1.0mL distilled water; dissolve 0.6g polylactic acid-caprolactone P(LLA-CL) [50:50] in 10mL dichloromethane, then add 0.05g SPAN-80, and ultrasonically shake Make it dispersed evenly; mix the above two solutions to obtain a uniform W / O emulsion.

[0041] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0042] The diameter of the obtained nanofiber is between 400nm and 1200nm.

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Abstract

The invention relates to an antibacterium nano fiber material and a preparation method thereof; the material comprises polymer superfine fiber and antibacterial agent, and the weight ratio is 60 to 98: 2 to 40; the preparation method comprises the following steps: (1) the antibacterial agent is dissolved in distilled water to prepare solution; the polymer superfine fiber is dissolved in methylene dichloride or chloroform organic solvent, emulsifier is added to be mixed evenly, to obtain solution which is dispersed evenly; (2) the two types of solution are mixed to obtain even water-in-oil W / O latex, and then electrostatic spinning is conducted to the latex, to obtain the antibacterium nano fiber material. The nano fiber material has good ventilation property and filterability, still has bacteriostasis and sterilization functions for a long time after stably releasing the antibacterial agent, has simple preparation method, adopts the biodegradable and bioabsorbable polymer as carrier materials, can be absorbed by the human body after fully releasing, is not left, does not need secondary operation and has no side effect.

Description

Technical field [0001] The invention belongs to the field of nanofibers and their preparation, and in particular relates to an antibacterial nanofiber material and its preparation method. Background technique [0002] Polymer antibacterial nanofibers can be used in many aspects including drug sustained release materials, clinical medicine, drinking water purification and food packaging. Fabric materials will be contaminated by microorganisms for various reasons, such as pathogenic bacteria, odor-producing bacteria, fungi and viruses, etc. These contaminated fabrics will become new breeding sites and transmission media for microorganisms. It has been confirmed that doctors' white coats, bed sheets, curtains and carpets in wards have become important channels for the breeding and infection of harmful microorganisms. Moreover, bacteria can survive on medical fibers for more than 3 months, and are easier to survive and reproduce on synthetic fibers than on natural cotton fibers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F1/10D01D5/00A61K47/34A61K47/26A61K47/32A61K47/36A61K47/42
Inventor 莫秀梅李晓强苏艳何创龙王红声
Owner DONGHUA UNIV
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