Antibacterial nano fiber material and preparation method thereof

A technology of nanofibers and antibacterial agents, applied in the field of nanofibers and their preparation, can solve the problems of unsatisfactory filtration effect of particles carrying pathogenic bacteria, large fiber pore size, etc., and achieve good drug dispersion, ultra-high specific surface area, and filtration good sex effect

Inactive Publication Date: 2009-02-04
DONGHUA UNIV
View PDF0 Cites 117 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When traditional non-woven fabrics, cotton yarns and other materials are used as medical fabrics, due to the thicker fabric fiber diameter and larger fiber pore size, the filtering effect on particles carrying pathogenic bacteria is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antibacterial nano fiber material and preparation method thereof
  • Antibacterial nano fiber material and preparation method thereof
  • Antibacterial nano fiber material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 0.05g of tetracycline hydrochloride in 1.0mL of distilled water; dissolve 0.6g of polylactic acid PLA in 10mL of dichloromethane, then add 0.05g of sodium dodecylsulfonate, and disperse it evenly by ultrasonic vibration; mix the above two solutions Mix to obtain a homogeneous water-in-oil (W / O) emulsion.

[0033] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0034] The diameter of the obtained nanofiber is between 200nm and 1600nm, and the fiber membrane can be seen to be light yellow of tetracycline hydrochloride when observed by naked eyes, indicating that tetracycline hydrochloride has been wrapped in it.

Embodiment 2

[0036] Dissolve 0.05g of penicillin in 1.0mL of distilled water; dissolve 0.6g of polylactic acid-caprolactone P(LLA-CL) [50:50] in 10mL of dichloromethane, then add 0.05g of SPAN-80, and ultrasonically shake The dispersion is uniform; the above two solutions are mixed to obtain a uniform W / O emulsion.

[0037] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0038] The diameter of the obtained nanofiber is between 400nm and 1200nm.

Embodiment 3

[0040]Dissolve 0.05g streptomycin in 1.0mL distilled water; dissolve 0.6g polylactic acid-caprolactone P(LLA-CL) [50:50] in 10mL dichloromethane, then add 0.05g SPAN-80, and ultrasonically shake Make it dispersed evenly; mix the above two solutions to obtain a uniform W / O emulsion.

[0041] Electrospinning was performed on the obtained emulsion so that the applied voltage was 20kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, and the diameter of the spinneret was 0.9mm.

[0042] The diameter of the obtained nanofiber is between 400nm and 1200nm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to an antibacterium nano fiber material and a preparation method thereof; the material comprises polymer superfine fiber and antibacterial agent, and the weight ratio is 60 to 98: 2 to 40; the preparation method comprises the following steps: (1) the antibacterial agent is dissolved in distilled water to prepare solution; the polymer superfine fiber is dissolved in methylene dichloride or chloroform organic solvent, emulsifier is added to be mixed evenly, to obtain solution which is dispersed evenly; (2) the two types of solution are mixed to obtain even water-in-oil W/O latex, and then electrostatic spinning is conducted to the latex, to obtain the antibacterium nano fiber material. The nano fiber material has good ventilation property and filterability, still has bacteriostasis and sterilization functions for a long time after stably releasing the antibacterial agent, has simple preparation method, adopts the biodegradable and bioabsorbable polymer as carrier materials, can be absorbed by the human body after fully releasing, is not left, does not need secondary operation and has no side effect.

Description

technical field [0001] The invention belongs to the field of nanofiber and its preparation, in particular to an antibacterial nanofiber material and its preparation method. Background technique [0002] Polymer antibacterial nanofibers can be used in many aspects including drug sustained release materials, clinical medicine, drinking water purification and food packaging. Fabric materials will be contaminated by microorganisms due to various reasons, such as pathogenic bacteria, odor-producing bacteria, fungi and viruses, etc. These contaminated fabrics will become new breeding places and media for microorganisms. It has been confirmed that doctors' white coats, bed sheets, curtains and carpets in wards have become important ways for the growth and infection of harmful microorganisms. Moreover, bacteria can survive on medical fibers for more than 3 months, and it is easier to survive and multiply on synthetic fibers than natural cotton fibers. Although these fabrics are st...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): D01F1/10D01D5/00A61K47/34A61K47/26A61K47/32A61K47/36A61K47/42
Inventor 莫秀梅李晓强苏艳何创龙王红声
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap