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Surface coating preparation method for reducing degradation rate of fully degradable magnesium alloy vascular stent

A magnesium alloy blood vessel and degradation rate technology, which is applied in the field of surface coating preparation to reduce the degradation rate of fully degradable magnesium alloy vascular stents, can solve the problem of excessive degradation of the coating, loss of protective effect, and binding force between the coating and the magnesium alloy matrix Weakness and other problems, to achieve the effect of reducing the corrosion rate, inhibiting the degradation of the matrix, and alleviating the shedding

Active Publication Date: 2017-01-04
JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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Problems solved by technology

[0004] Chinese patent CN201310306991.1 discloses a method for preparing a surface coating that can regulate the degradation rate of a magnesium alloy stent. The substrate of the stent is a Mg-Nd-Zn-Zr magnesium alloy, and the surface is coated with additive particles such as alkaline earth metals Polylactic acid and other polymers control the degradation rate of the coating by adjusting the content of additives, thereby controlling the degradation rate of the vascular stent, but the bonding force between the coating and the substrate is not good
[0008] It can be seen that in order to solve the defects that magnesium alloy is degraded too fast as a material for vascular stents, and there is not enough time to complete the functions of dredging blood vessels and promoting endothelial healing, the commonly used method is to coat polymer coatings, and the polymer is polylactic acid. , polycaprolactone and other polyester polymers, but the method of direct coating makes the bonding force between the coating and the magnesium alloy substrate weak, resulting in poor coating protection ability, premature and too fast degradation of the coating, peeling off and losing its protection effect

Method used

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  • Surface coating preparation method for reducing degradation rate of fully degradable magnesium alloy vascular stent
  • Surface coating preparation method for reducing degradation rate of fully degradable magnesium alloy vascular stent
  • Surface coating preparation method for reducing degradation rate of fully degradable magnesium alloy vascular stent

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preparation example Construction

[0040] (1) Preparation of the silane coupling agent coating, the silane coupling agent is mixed with an organic solvent to form a silane coupling grafting agent, and the silane coupling grafting agent is grafted to the magnesium for biodegradable vascular stent by dip coating method The surface of the alloy is heated and solidified to form a cross-linked silane coupling agent layer;

[0041] (2) The preparation of polymer coating, the granular polymer is dissolved in organic solvent and mixed to form polymer spin coating solvent, and adopts spin coating method to coat polymer spin coating solvent on the silane coupling compound with the above steps (1). The surface of the sample coated with the grafting agent was vacuum-dried, and the polymer coating was formed after the solvent of the polymer spin-coating was volatilized.

[0042] As an optimization, the silane coupling agent is γ-aminopropyltriethoxysilane KH550, N-(β-aminoethyl)-γ-aminopropylmethyldimethoxysilane KH602, γ-a...

Embodiment 1

[0051] In the first embodiment of the surface coating preparation method for reducing the degradation rate of fully degradable magnesium alloy stents involved in the present invention, the magnesium alloy used for biodegradable stents is Mg-Zn-Y-Nd, and the silane coupling agent is γ-Aminopropyltriethoxysilane KH550, the granular polymer is dissolved in 100,000 (LA:PA=75:25) polylactic acid-glycolic acid particles, and the organic solvent is dichloromethane solution. The method includes the following steps:

[0052] Step 1, preparation of silane coupling agent coating: Dissolving silane coupling agent γ-aminopropyltriethoxysilane KH550 in organic solvent dichloromethane to form silane with a volume percentage of 5% (v / v) The dichloromethane solution of the coupling grafting agent KH550 was stirred for 0.5h, and the biodegradable Mg-Zn-Y-Nd magnesium alloy wire cutting was processed into thin slices with a diameter of ∅=10mm and a wall thickness of d=0.8mm, and polished to 2000...

Embodiment 2

[0056] In the second embodiment of the surface coating preparation method for reducing the degradation rate of fully degradable magnesium alloy stents involved in the present invention, the method includes the following steps:

[0057] Step 1, preparation of silane coupling agent coating: Dissolving silane coupling agent γ-aminopropyltriethoxysilane KH550 in dichloromethane to form a silane coupling with a volume percentage of 5% (v / v) The dichloromethane solution of grafting agent KH550 was stirred for 0.5h; the biodegradable magnesium alloy was wire-cut into thin slices with a diameter of ∅=10mm and a wall thickness of d=0.8mm, and polished to 2000 # , after cleaning with acetone and deionized water, ultrasonic cleaning in absolute ethanol for 30min; soak the sample in 5% (v / v) silane coupling grafting agent KH550 solution for 1.0h, and silane coupling grafting agent KH550 branch to the surface of the magnesium alloy, heat and cure at 100°C for 60 minutes to form a cross-lin...

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Abstract

The present invention relates to a surface coating preparation method for reducing the degradation rate of a fully degradable magnesium alloy stent. The method first prepares a silane coupling agent coating on the surface of a magnesium alloy: mixing a silane coupling agent with an organic solvent, and dip coating The silane coupling agent is grafted onto the magnesium alloy surface of the biodegradable vascular stent by heating and curing to form a coating; secondly, a polymer coating is prepared on the surface after the pretreatment of the silane coupling agent, and the polymer is coated by the spin coating method. Coated on the surface of the sample treated with the silane coupling agent, dried in vacuum, and the polymer coating was formed after the solvent evaporated; through this technical scheme, the polymer coating coated on the surface of the magnesium alloy pretreated by the silane coupling agent , it has a strong binding force with the surface of the fully degradable magnesium alloy vascular stent, inhibits the rapid degradation of the magnesium alloy matrix, improves its biocompatibility, and the final coating will completely degrade with the matrix, and has no toxic side effects on the human body.

Description

technical field [0001] The invention relates to the preparation of a magnesium alloy biological material, in particular to a method for preparing a surface coating for reducing the degradation rate of a fully degradable magnesium alloy vascular stent. Background technique [0002] Interventional vascular stent therapy has become the most important method in the field of cardiovascular disease treatment for more than ten years. The research on vascular stent materials has also experienced permanent bare stents, permanent drug-loaded stents, fully degradable metal stents and polymer stents. three stages of development. [0003] At present, most of the permanent bare stents used in clinical practice are stainless steel, cobalt-chromium alloy and nickel-titanium alloy. After completing the treatment function, they are still left in the human body as foreign bodies, which stimulate the vessel wall and significantly increase the intimal hyperplasia rate of the vessel. The resteno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08
CPCA61L31/10A61L31/022A61L2420/02A61L31/14C08L67/04
Inventor 奚廷斐刘婧王敏张志雄
Owner JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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