A jugular vein intubation drug delivery device for cerebral infarction

A drug delivery device and jugular vein technology, applied in the field of medical devices, can solve problems such as lack of elasticity of the skull, inaccurate drug delivery sites, and biased experimental results, achieving long drug delivery duration, increasing the success rate of experiments, and reducing adverse events The effect of the reaction

Active Publication Date: 2021-12-10
上海澎立生技医药研究有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of using the implanted micro-osmotic pressure pump to administer cerebral infarction rats, the skull of the rat needs to be perforated. The surgical trauma is large, which is not conducive to the recovery of the rat. The skull is not elastic, making the catheter easy to detach. This leads to inaccurate administration sites, which lead to bias in experimental results.

Method used

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  • A jugular vein intubation drug delivery device for cerebral infarction

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Comparison scheme
Effect test

Embodiment 1

[0045] Such as figure 1 As shown, the present invention provides a jugular vein intubation drug delivery device for cerebral infarction, which includes an inner membrane 3 and a semipermeable body 1 for forming a closed first accommodation space for accommodating medicines. The inner membrane 3 is tightly connected to the semi-permeable body 1 in such a way that it can form a second accommodation space for the osmotic agent 2 . The first accommodation space and the second accommodation space are separated by the inner membrane 3 . The osmotic agent 2 is installed in the storage space so as to allow moisture in the external environment to flow into the storage space based on the osmotic pressure. The semi-permeable body 1 is set so that only water can pass through it. The inner membrane 3 is set as a water-impermeable membrane layer in such a way that it can prevent the moisture that is formed by the osmotic pressure formed by the osmotic agent 2 from entering the second acco...

Embodiment 2

[0052] The drug delivery device of the present invention is applied to the jugular vein drug delivery of cerebral infarction rats, and the specific implementation method is as follows.

[0053] First make the cerebral infarction rat model, the rat cerebral infarction model making method of the present invention is as follows:

[0054] Before the operation, the rats need to fast overnight, and the rats are weighed, and the weight of the rats is 180g-220g.

[0055] a. Use a marker pen to mark the tie line at a distance of 1.8cm from the head;

[0056] b. Intraperitoneal injection of 10mg / kg Shutai anesthesia into the rat, fixed in supine position, cut off neck hair, and operated under iodophor disinfection skin surgery microscope;

[0057] c. An incision of 1.5 cm in the middle of the neck; the right sternocleidomastoid muscle was exposed after the fascia lata was cut open, and the carotid sheath was exposed after the deep separation between the sternocleidomastoid muscle and t...

Embodiment 3

[0075] The device is used to carry out the jugular vein administration experiment on rats.

[0076] The improved nerve injury severity score was performed on 25 rats 24 hours after the model was made, and the improved nerve injury severity score of 15 rats was between 10 and 13 points, and they were randomly divided into 3 groups: drug delivery device group, Routine administration group and control group, 5 rats in each group. The drug delivery device implanted the drug delivery device with the above-mentioned operation for drug delivery, and the conventional drug delivery group used a micro-injector for jugular vein drug administration, 60 μl VEGF solution, VEGF content was 4 μg, and the drug delivery rate was 4 μl / min. Rats in the control group were microinjected with 60 μl of normal saline at an injection speed of 4 μl / min. After the experiment, 24 hours after the model was made, the improved nerve injury severity scores of the three groups of rats were stable at 10-13 poi...

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Abstract

The present invention relates to a jugular vein intubation drug delivery device for cerebral infarction, at least comprising an inner membrane for constituting a first accommodation cavity for containing medicine and a rigid semi-permeable body for water to flow through, the inner membrane and the semi-permeable body according to The means capable of forming a second receiving chamber for holding the osmotic agent are connected in a closed connection with each other. The sum of the volumes of the first accommodation chamber and the second accommodation chamber is defined by a rigid semi-permeable body, and the first accommodation chamber can change its shape or size to adapt to the osmotic pressure of the second accommodation chamber due to the presence of osmotic agent in the external environment Under the action of the semipermeable body entering the second accommodation cavity and combining with the osmotic agent, the change in shape or size is adjacent to each other with the flexible inner membrane as the boundary. Through the above-mentioned setting method, the device is used for jugular vein intubation administration of the rat cerebral infarction model, with less trauma, continuous and stable administration, and avoiding the trouble of administration on weekends and nights.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a jugular vein intubation drug delivery device for cerebral infarction. Background technique [0002] Cerebral infarction is a disease that seriously endangers human health. At present, there is no more effective method except timely thrombolytic therapy within 4-5 hours of onset. Cerebral infarction in the elderly is a type of critical cerebrovascular disease. After the onset, it may lead to insufficient blood supply to the brain tissue, resulting in local brain tissue ischemia, hypoxic necrosis, affecting the patient's neurological function, and causing the patient to become conscious. , language, and physical impairments. In the process of treating elderly patients with cerebral infarction, the main method is intravenous thrombolysis, but the application effect of conventional intravenous infusion of thrombolysis is not ideal. Therefore, a better method of intravenous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 段继峰杨平戴飞鸿俞诚
Owner 上海澎立生技医药研究有限公司
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