32results about How to "No need for secondary surgery" patented technology

The invention relates to an antibacterium nano fiber material and a preparation method thereof; the material comprises polymer superfine fiber and antibacterial agent, and the weight ratio is 60 to 98: 2 to 40; the preparation method comprises the following steps: (1) the antibacterial agent is dissolved in distilled water to prepare solution; the polymer superfine fiber is dissolved in methylene dichloride or chloroform organic solvent, emulsifier is added to be mixed evenly, to obtain solution which is dispersed evenly; (2) the two types of solution are mixed to obtain even water-in-oil W/O latex, and then electrostatic spinning is conducted to the latex, to obtain the antibacterium nano fiber material. The nano fiber material has good ventilation property and filterability, still has bacteriostasis and sterilization functions for a long time after stably releasing the antibacterial agent, has simple preparation method, adopts the biodegradable and bioabsorbable polymer as carrier materials, can be absorbed by the human body after fully releasing, is not left, does not need secondary operation and has no side effect.

The invention relates to a degradable nano-short fiber material for tissue repair. The nano-short fiber material is composed of nano-short fibers, wherein the diameter of the nano-short fibers is 200-800 nm, and the length of the nano-short fibers does not exceed 500 [mu] m; the length of at least 93% of the nano-short fibers in the nano-short fiber material is within 20-200 [mu] m, and the stacking density of the nano-short fiber material is 0.001-0.099 g/cm<3>. According to the nano-short fiber material, the length of the nano-fibers is shortened, the dispersing performance and repairing performance of the nano-fibers are improved, and the application range of the nano-short fiber material is expanded.

The invention relates to the technical field of medical instruments, in particular to a degradable bile duct bracket with stone dissolution function and a preparation method thereof. The degradable bile duct bracket is prepared by the following raw materials in proportion: 60-98% by weight (wt) of degradable polymer, 0.1-2.0 % by weight of nucleating agent, 1-15 % by weight of plasticizer, and the balance of stone dissolution drug, wherein the total weight amounts to 100%. The degradable bile duct bracket is obtained by evenly mixing the degradable polymer, the nucleating agent, the plasticizer and the stone dissolution drug, and then fusing and extruding the mixture through a medical catheter precise extruder; by successfully selecting proper degradable polymer, nucleating agent and plasticizer, the defects of the plastic bracket and metal bracket in the bile duct interventional therapy are overcome; moreover, by adding the stone dissolution drug, the curative effective of gall-stone is improved; therefore, the degradable bile duct bracket has wide application prospect.

The invention discloses a fabrication method for a fracture fixator, which includes the following steps: scanning the fracture and the corresponding healthy-side part of a patient, and acquiring initial data; adopting three-dimensional software to convert the initial data into a three-dimensional model, so that a skeleton model at the fracture and the corresponding healthy-side part of the patient is obtained; utilizing the three-dimensional software to carry out a fixation analysis on the skeleton model at the fracture and design a fracture fixator model; preparing bioactive artificial bone material; converting the designed fracture fixator model into a rapid prototyping file format, and feeding the prepared bioactive artificial bone material as prototyping material into a rapid prototyping machine to produce the fracture fixator. The invention has the advantage that the rapid prototyping technique, the three-dimensional computer design and the bioactive artificial bone material are combined to fabricate degradable fracture fixators adapted to different parts and different degrees of individualized shape designs.

The invention relates to an auxiliary calcaneus reduction fixing device for calcaneus fracture occlusion or minimal invasion reduction internal fixation. The auxiliary calcaneus reduction fixing device for calcaneus fracture occlusion or minimal invasion reduction internal fixation comprises a right outer side splint or a left outer side splint, a right inner side splint or a left inner side splint and a driving device used for fixing the right outer side splint and the right inner side splint or fixing the left outer side splint and the left inner side splint, wherein the driving device drives the right outer side splint and the right inner side splint or fixing the left outer side splint and the left inner side splint to move relatively. Compared with an existing operation method, the auxiliary calcaneus reduction fixing device does not need to carry out open reduction and internal fixation, thereby having the advantages of a small wound and accurate anatomical reduction. The right outer side splint 1 or the left outer side splint 2, and the right inner side splint 3 or the left inner side splint 4 correspond to the outer side wall or inner side wall of the right calcaneus in shape, and therefore the auxiliary calcaneus reduction fixing device has the advantages of being firm in fixation, few in complication, free of a second operation, small in pain of a patient and the like, and calcaneus fracture is made to be back to minimally invasive therapy.

The invention discloses a high-strength degradable bone fracture binding band and a preparation method of the high-strength degradable bone fracture binding band and belongs to the technical field of medical instruments. The bone fracture binding band is formed by combined preparation of a high-strength orientation fiber band and a randomly arranged fiber film or a random orientation thin film. The degree of crystallinity is increased through a nucleating agent, and the orientation technology is adopted to obtain the high-strength orientation fiber band; the bone fracture binding band is prepared under the condition that the linear speed of a disc-shaped yarn take-up device is greater than or equal to 500 m/min by the adoption of the solution electrospinning technology; the mass percent of a spinning solution is that a degradable polymer accounts for 5-12%, the nucleating agent accounts for 0.5-2%, and a solvent accounts for 86-95%. The orientation fiber band is arranged in a single orientation or double orientations, the random fiber film is sprayed on the surface of the orientation fiber band, or the random orientation thin film is stacked on the orientation fiber band, and then the bone fracture binding band is prepared by means of ultrasonic welding. The tensile strength and tensile modulus of the prepared bone fracture binding band are improved substantially compared with those of a randomly arranged electrostatic spinning film, and the bone fracture binding band has good application prospect with respect to repair and fixation of clinical bone fractures.

The invention relates to a combined joint movement apparatus comprising two carbon fiber poles, multiple connection block components and multiple wire clamping components. One connection block component is connected to the head of each carbon fiber pole, the two connection block components of the heads of the carbon fiber poles are connected with each other via a screw, more than one of the connection block components is arranged on a pole body of each carbon fiber poles, more than one of the wire clamping components is connected on each connection block component on the pole bodies, and Kirschner wires are arranged on each wire clamping component. Connection blocks of the heads of the carbon fiber poles are connected serially via screws, the first carbon fiber pole and the second carbon fiber pole are in the state of rotating freely and axially around the screws 5 or being locked, movement of joints is facilitated by dynamic and static combination, and poor blood circulation or muscle atrophy is prevented. The Kirschner wires pierce for fixation from the outside, minimally invasive treatment of fracture is realized, second operation is not required, the joints can be moved after operation, and the joint functions are unaffected after fracture healing.

The invention discloses a scaffold material capable of blood sugar induced controlled-release of drugs and used for periodontal treatment and a preparation method thereof. The preparation method is characterized by comprising the following steps: dissolving collagen or gelatin or fibrin in a 0.5 to 5% dilute hydrochloric acid solution or 0.1 to 1% dilute acetic acid solution, or dissolving sodium alginate protein in double distilled water to form a solution with a concentration of 0.1 to 5 wt%; adjusting the pH value of the solution with alkali to 6.5 to 7.5; adding 10 to 20 parts of a natural degradable substance solution, 10 to 20 parts of quaternized chitosan, 1 to 5 parts of glucose oxidase and 5 to 15 parts of anti-inflammatory protein into a reaction vessel and carrying out stirring at a speed of 500 to 5000 rpm at a temperature below 4 DEG C for 10 to 30 min so as to obtain a uniform solution; adding 2 to 6 parts of sodium phosphate into the solution drop by drop; and adding obtained liquid into equipment with a cold eluting agent and into a plastic die with a constant temperature of 4 DEG C, disposing the liquid at a temperature of -20 DEG C for 2 to 4 h, refrigerating the liquid at a temperature of -80 DEG C for 24 to 48 h and carrying out freeze drying at a temperature of -100 DGE C so as to prepare the drug-loaded scaffold material. The scaffold material is stored in equipment with a temperature of 4 DEG C after disinfection by Co60 irradiation.

The invention provides a dental implant with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure. The dental implant consists of a dental implant and a drug controlled-release system with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure, and the drug controlled-release system is composed of an osteogenesis layer, an anti-inflammation layer and a blood glucose sensing layer. The osteogenesis layer is composed of chitosan hydrogel and nano-hydroxyapatite dispersed in the chitosan hydrogel, the anti-inflammation layer is composed of cross-linked quaternized chitosan hydrogel and anti-inflammation substances and glucose oxidase which are dispersed in the cross-linked quaternized chitosan hydrogel, and the blood glucose sensing layer is a coating composed of glucose oxidase. The surface of the dental implant is provided with a nanopore structure, the nanopore structure of the dental implant is filled with the osteogenesislayer of the drug controlled-release system, the osteogenesis layer coats the dental implant, the anti-inflammation layer coats the osteogenesis layer, and the blood glucose sensing layer coats the anti-inflammation layer. The dental implant can promote osseointegration in a hyperglycemia state, provides a new anti-inflammation treatment technology for patients with diabetes mellitus, and can meetthe clinical requirements of dental implant repair of the patients with diabetes mellitus.

A minitype sleeve kirschner wire fixing device used for fixing a fracture of the metacarpal bone comprises a kirschner wire with puncture heads at the two ends, a minitype sleeve guider, a hollow cylindrical minitype sleeve with the zigzag front end, a first minitype sleeve core and a second minitype sleeve core. The minitype sleeve guider is composed of a handle and a hollow cylindrical guide sleeve with the zigzag front end, the handle is movably connected with the guide sleeve, the first minitype sleeve core and the second minitype sleeve core are kirschner wires with caps at the tail ends, and the minitype sleeve and the kirschner wire with the puncture heads are combined to form a minitype sleeve kirschner wire. The minitype sleeve kirschner wire fixing device used for fixing the fracture of the metacarpal bone aims to reduce damage to the interosseus during surgical method operation and popularize the coronal transverse fixing technology for the fracture of the metacarpal bone.