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A kind of polylactic acid/β-calcium phosphate/type I collagen composite nerve guide and its preparation method

A technology of nerve conduit and polylactic acid, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor conduit performance and inability to meet the needs of nerve repair, and achieve the goal of facilitating the entry of nerve growth factor and glucose , solve the actual needs, and the effect of simple preparation technology

Active Publication Date: 2020-01-14
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor performance of catheters made of a single material, they cannot well meet the needs of nerve repair, and nerve catheters made of multiple materials can solve this problem well.

Method used

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  • A kind of polylactic acid/β-calcium phosphate/type I collagen composite nerve guide and its preparation method
  • A kind of polylactic acid/β-calcium phosphate/type I collagen composite nerve guide and its preparation method
  • A kind of polylactic acid/β-calcium phosphate/type I collagen composite nerve guide and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 0.3g of polylactic acid and 0.9g of type I collagen in 10mL of organic solvent (dichloromethane:ethyl acetate volume ratio is 7:4) with an electronic balance, and use an electromagnetic stirrer to stir for 6h to mix the solution evenly. To obtain a uniform and stable polylactic acid / type I collagen spinning solution, use a No. 21 needle to control spinning parameters (spinning solution flow rate 0.1mm / min, positive high voltage +10kV, negative high voltage -3kV, spinning membrane receiving device and jet The needle distance is 13cm), and the spinning solution is made into a 0.15mm thick spinning film (inner layer); similarly, 0.8g polylactic acid is weighed with an electronic balance, and 0.2g β-calcium phosphate is dissolved in 10mL organic solvent (dichloromethane: The volume ratio of ethyl acetate is 7:4), using an electromagnetic stirrer to stir for 6h, the solution is mixed to obtain a uniform and stable polylactic acid / β-calcium phosphate spinning solution, u...

Embodiment 2

[0034] Weigh 0.4g polylactic acid and 1.2g type I collagen in 10mL organic solvent (dichloromethane: ethyl acetate volume ratio is 7:4) with an electronic balance, and use an electromagnetic stirrer to stir for 6h to mix the solution evenly. To obtain a uniform and stable polylactic acid / type I collagen spinning solution, use a No. 21 needle to control spinning parameters (spinning solution flow rate 0.2mm / min, positive high voltage +10kV, negative high voltage -3kV, spinning membrane receiving device and jet The needle distance is 14cm), and the spinning solution is made into a 0.15mm thick spinning film (inner layer); similarly, 1.0g polylactic acid is weighed with an electronic balance, and 0.25g β-calcium phosphate is dissolved in 10mL organic solvent (dichloromethane: The volume ratio of ethyl acetate is 7:4), using an electromagnetic stirrer to stir for 6h, the solution is mixed to obtain a uniform and stable polylactic acid / β-calcium phosphate spinning solution, using No...

Embodiment 3

[0036]Weigh 0.5g of polylactic acid and 1.5g of type I collagen in 10mL of organic solvent (dichloromethane:ethyl acetate volume ratio is 7:4) with an electronic balance, and stir for 6h with an electromagnetic stirrer to mix the solution evenly. To obtain a uniform and stable polylactic acid / type I collagen spinning solution, use a No. 21 needle to control spinning parameters (spinning solution flow rate 0.1mm / min, positive high voltage +10kV, negative high voltage -3kV, spinning membrane receiving device and jet The needle distance is 14cm), and the spinning solution is made into a 0.15mm thick spinning film (inner layer); similarly, 1.2g polylactic acid is weighed with an electronic balance, and 0.3g β-calcium phosphate is dissolved in 10mL organic solvent (dichloromethane: The volume ratio of ethyl acetate is 7:4), using an electromagnetic stirrer to stir for 6h, the solution is mixed to obtain a uniform and stable polylactic acid / β-calcium phosphate spinning solution, usin...

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Abstract

The invention belongs to the technical field of medical biological materials, and in particular relates to a polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit and a preparation method thereof. The polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit is prepared as follows: dissolving polylactic acid and I type collagen in an organic solvent, evenly mixing, using electrospinning technique to prepare a nerve conduit inner layer membrane; dissolving the polylactic acid and beta-calcium phosphate in the organic solvent, evenly mixing, spraying the nerve conduit inner layer membrane with a spinning liquid by the electrospinning technique to form a nerve conduit outer layer membrane, and preparing a polylactic acid / beta-calcium phosphate / I type collagen composite electrospinning film into a tubular conduit, putting the tubular conduit in a vacuum drying oven to fully evaporate the organic solvent to obtain the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit. The three material of the polylactic acid, the beta-calcium phosphate and the I type collagen are compounded by the electrospinning technique for complement of advantages, the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit has excellent mechanical properties, cellular affinity and hydrophilicity, can simulate the structure of an extracellular matrix, and is bionic.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, in particular to a polylactic acid / beta-calcium phosphate / type I collagen composite nerve guide and a preparation method thereof. Background technique [0002] Due to the occurrence of medical accidents and traffic accidents, the phenomenon of peripheral nerve injury is very common in daily life. In recent years, the number of nerve injury cases has been on the rise. Peripheral nerve injury generally causes degeneration of the nerve innervation area and severe functional impairment. Obstacles, long-term damage to the physical and mental health of patients and the decline in quality of life have become a major challenge in the world of medicine, so it is extremely urgent to find a way to repair peripheral nerve damage. [0003] At present, in the clinical repair of peripheral nerve injuries, autologous nerve transplantation is mainly used. Autologous nerve transplantation is often con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/18A61L27/24A61L27/50A61L27/56A61L27/58
CPCA61L27/12A61L27/18A61L27/24A61L27/50A61L27/56A61L27/58A61L2430/32C08L67/04
Inventor 王欣宇林飞
Owner WUHAN UNIV OF TECH
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