A nano-short fiber material for tissue repair and its preparation method and application

A tissue repair and nanofiber technology, used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as inability to adapt to minimally invasive surgery, and achieve the effect of maintaining biocompatibility, tissue repair performance, and good dispersion performance

Active Publication Date: 2021-07-16
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the defect that the existing electrospun tissue repair products are mostly sheets or blocks composed of continuous long fibers, which cannot meet the requirements of minimally invasive surgery, and provide a nano-short fiber material for tissue repair

Method used

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  • A nano-short fiber material for tissue repair and its preparation method and application
  • A nano-short fiber material for tissue repair and its preparation method and application
  • A nano-short fiber material for tissue repair and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Embodiment 1 Preparation of polylactic acid nano short fiber material

[0061] This embodiment provides a short polylactic acid nanofiber material, which is prepared by the following method.

[0062] S1. Add 0.8g polylactic acid into 10ml hexafluoroisopropanol solution, stir at room temperature until dissolved, and make 8% (w / v) spinning solution;

[0063] S2. Add the spinning solution into the syringe, add an extension tube to the front end of the syringe and connect a 20G needle, place the syringe on the micro-injection pump, the needle is perpendicular to the receiving plate, and the lower part of the receiving plate is grounded; set the injection rate to 6ml / h, when When the solution is extruded from the needle tip, a voltage of 22kv is applied to the needle tip; at this time, nanofibers are ejected and collected on the receiving plate to form a nanofiber film;

[0064] S3. Vacuum-dry the nanofibrous membrane for 48 hours to remove hexafluoroisopropanol, then trans...

Embodiment 2

[0069] The preparation of embodiment 2 PLGA / gelatin nano-short fiber material

[0070] This embodiment provides a PLGA / gelatin nano-short fiber material, which is prepared by the following method.

[0071] S1. Add 1g of PLGA to 10ml of hexafluoroisopropanol solution, stir at room temperature until dissolved, then add 0.2g of gelatin, and dissolve to make a 10% (w / v) spinning solution;

[0072] S2. Add the spinning solution into the syringe, add an extension tube to the front end of the syringe and connect a 23G needle, place the syringe on the micro-injection pump, the needle is perpendicular to the receiving plate, and the lower part of the receiving plate is grounded; set the injection rate to 2ml / h, when When the solution is extruded from the needle tip, a voltage of 30kv is applied to the needle tip; at this time, nanofibers are ejected and collected on the receiving plate to form a nanofiber film;

[0073] S3. Vacuum-dry the nanofibrous membrane for 48 hours to remove he...

Embodiment 3

[0079] This embodiment provides a short polylactic acid nanofiber material, which is prepared by the following method.

[0080] S1. Add 0.8g polylactic acid into 10ml hexafluoroisopropanol solution, stir at room temperature until dissolved, and make 8% (w / v) spinning solution;

[0081] S2. Add the spinning solution into the syringe, add an extension tube to the front end of the syringe and connect a 20G needle, place the syringe on the micro-injection pump, the needle is perpendicular to the receiving plate, and the lower part of the receiving plate is grounded; set the injection rate to 6ml / h, when When the solution is extruded from the needle tip, a voltage of 22kv is applied to the needle tip; at this time, nanofibers are ejected and collected on the receiving plate to form a nanofiber film;

[0082] S3. Vacuum-dry the nanofibrous membrane for 48 hours to remove hexafluoroisopropanol, then transfer it to 25% ammonia water according to the mass-to-liquid ratio of 1:50, let i...

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Abstract

The invention relates to a nano-short fiber material for tissue repair, a preparation method and application thereof. The nano-short fiber material includes nano-short fibers with a diameter of 200-800 nm and a length of 10-200 μm, and at least one nano-short fiber has a porous structure on its surface. The nano-short fiber material provided by the present invention shortens the length of the nano-fiber and has better dispersion performance, and the nano-short fiber material is made of a biodegradable biomaterial with good biocompatibility and tissue repair performance, and does not need to be removed , no need for secondary surgery, especially suitable for tissue repair of small area or deep defect. In addition, the nano-short fiber material provided by the present invention can not only be prepared into powder, injection, etc., and can be used alone in combination with minimally invasive, laparoscopy, injection and other surgical methods, and can also be used in combination with other materials.

Description

technical field [0001] The invention belongs to the field of tissue repair materials, and more particularly relates to a nano-short fiber material for tissue repair and its preparation method and application. Background technique [0002] Minimally invasive surgery has become a new trend in clinical surgery. Compared with traditional surgery, minimally invasive surgery results in smaller incisions, faster recovery for patients, and a significantly lower incidence of complications such as infection. With the promotion of minimally invasive surgery, the cooperation of corresponding minimally invasive medical devices is also required. Tissue repair products, as high-end consumables in medical devices, can provide necessary support and filling for defect parts. At the same time, their microstructure is conducive to the adhesion, migration and proliferation of tissue cells, which greatly accelerates the repair of defect parts. [0003] Among tissue repair products, tissue engin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/18A61L27/22A61L27/54
CPCA61L27/18A61L27/222A61L27/50A61L27/54A61L27/56A61L2400/12C08L67/04
Inventor 张海涛邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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