Novel allogeneic amnion composite material repair catheter and preparation method thereof

Abstract

The invention discloses a novel allogeneic amnion composite material repair catheter and a preparation method, and relates to the field of nerve repair catheters. The preparation method comprises the following steps: firstly, after a puerpera cesarean placenta is obtained, conducting serum detection, adding a protective agent for protection after the placenta is qualified, conducting refrigeration, soaking and washing the placenta through a washing solution, then stripping the amnion, adding the protective agent to maintain the activity of the amnion; and secondly, selecting modified high polymer materials such as polylactic acid and amino polylactic acid which meet the requirements of controllable tensile strength, compressive strength, elasticity, tensile strength, molecular weight and degradation time, adhesion performance, safety and metabolic pathways, positively charging the modified high polymer materials. The amniotic membrane belt is rolled into a pipe shape and distributed inside and outside the high polymer materials; after being freeze-dried, the composite material can be firmly adhered to a polymer tubular material to prepare a novel allogenic amnion composite material nerve repair conduit taking a composite polymer material as a skeleton, so that the problem that the amnion material is softened when meeting water in vivo can be effectively solved.

Description

technical field [0001] The invention relates to the field of nerve repair catheters, in particular to a novel allogeneic amniotic membrane composite material repair catheter and a preparation method thereof. Background technique [0002] The peripheral nervous system connects the brain, spinal cord and remote organs and systems, so that the central nervous system can effectively and precisely control various activities of the body. It is also called the peripheral nervous system. The treatment of nerve injuries mainly includes two types: when When the nerve defect distance is short, the "end-to-end" anastomosis technique is usually used to directly suture the two ends of the nerve; when the long-distance nerve defect cannot be directly sutured, autologous nerve transplantation is used to repair the long-distance nerve injury. And this method has become the main means of clinical nerve repair. [0003] At present, with the development of tissue engineering, the use of the ba...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is: in order to solve the long-distance nerve defect that needs autologous nerve transplantation, the donor source is limited, and the tissue structure is difficult to match; the activity of amnion is low; It will decompose and lose its rigidity within two months, and the catheter will collapse in blocks when the material is degraded. A new allogeneic amniotic membrane composite material repair catheter and its preparation method are provided.