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Topical hemostatic composition

A composition and topical technology, applied in the directions of drug combination, carbohydrate active ingredients, blood diseases, etc., can solve problems such as inability to exert hemostatic effect, and achieve the effect of promoting tissue repair and anti-wound infection

Pending Publication Date: 2022-04-01
林春木 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] Three: Can not play a hemostatic effect in water

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0055] As a first preferred embodiment of one aspect of the present invention, the content of N-acetylglucosamine accounts for 3-30% w / v of the total amount of the local hemostatic composition.

[0056] As a second preferred embodiment of one aspect of the present invention, the local hemostatic composition may further include one or more other sugars selected from sucrose, maltose, invert sugar, glucose and fructose. The content of other carbohydrates accounts for 1-80% w / w, preferably 10-70% w / w of the total amount of the local hemostatic composition.

[0057] The other sugars are used to increase the viscosity of the local hemostatic composition of the present invention, quickly absorb water in blood through osmotic pressure, and make plasma proteins and blood cells easy to aggregate.

[0058] As a third preferred embodiment of one aspect of the present invention, the local hemostatic composition may also include calcium chloride (CaCl 2 ), sodium chloride (NaCl), ferric c...

example 1

[0132] Example 1: Hemostatic effect of rat femoral artery bleeding

[0133] Observation group: test drugs 1-9

[0134] Control group: normal saline as control

[0135] Select 770 healthy rats, weighing 130-180g, both male and female. The experimental animals were divided into control group and observation group, and the experimental animals in the observation group (groups 1 to 9 of test drugs) were randomly divided into 9 groups, with 80 animals in each group. Control group (10% normal saline) 50 rats. The left femoral artery was cut off, the observation group soaked the cotton wool in the test drug, the control group soaked the cotton wool in 10% saline, and then directly pressed the cotton wool on the bleeding site for ten seconds and then let go. See Table 3 for the results of local bleeding such as bleeding in the observation group.

[0136] Table 3, the hemostatic effect of rat femoral artery cutting bleeding

[0137]

[0138]

[0139] *(Note: Compared with the ...

example 2

[0141] Example 2: The hemostatic effect of porcine femoral artery severed bleeding

[0142] Experimental animals: select healthy pigs, weighing 60-70kg, male or female

[0143] Observation group: test drugs 7 and 8

[0144] Control group 1: Zeolite hemostatic agent

[0145] Control group 2: hemostatic powder and antibacterial powder (Fuzhou Juxiangtang Medical Supplies Co., Ltd., China)

[0146] Method: Select 400 healthy pigs, both male and female. Divide into control group and observation group at random, wherein with observation group (experimental drug 7 and 8 groups) 300 are divided into 3 subgroups at random, each group 100, control group 100 are divided into 2 subgroups at random again, every group 50 only. The femoral artery was surgically cut. The observation group soaked the cotton wool in the test drug, and then directly pressed the cotton wool on the bleeding site for four minutes and then let it go. The control group used zeolite hemostatic agent or hemostat...

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Abstract

The topical hemostatic composition comprises 0.5-50% w / v of N-acetylglucosamine and distilled water as a solvent. The topical hemostatic composition may also include one or more other sugars selected from sucrose, maltose, invert sugars, glucose, and fructose. The topical hemostatic composition may also include a salt of one or more selected from the group consisting of calcium chloride (CaCl2), sodium chloride (NaCl), ferric trichloride (FeCl3), alum [KAl (SO4) 2], and copperas (FeSO4). The local hemostatic composition can be applied to various traumatic hemorrhage including main artery hemorrhage, surgical hemorrhage or alimentary tract hemorrhage and the like, and also has a hemostatic curative effect in water.

Description

technical field [0001] The present invention relates to a topical hemostatic composition comprising N-acetylglucosamine. Background technique [0002] Bleeding often endangers the life of the injured, therefore, timely and effective emergency hemostasis is particularly important. [0003] It is reported that the total blood volume of a person accounts for 8% of the body weight. In the total blood volume, if the blood loss is 20%, hemorrhagic shock will occur, and in severe cases, death will occur. [0004] Hemostatic therapy is so important that many hemostatic methods, hemostatic drugs, and hemostatic devices have been developed and used. [0005] As local hemostatic drugs, drugs that constrict local blood vessels or drugs that promote blood coagulation through astringent, oxidative or protein coagulation effects are selected and used. [0006] Representative local hemostatic drugs include epinephrine, hydrogen peroxide, potassium permanganate, thrombin solution, hyperton...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7008A61K31/70A61K33/00A61K9/08A61P7/04A61P7/02
CPCA61K31/7008A61P7/04A61K9/08A61K47/02A61K47/26A61K9/0014A61K9/0053A61P17/02A61K31/7004A61K31/7016A61K33/14A61K33/20A61K33/26A61K2300/00
Inventor 林春木
Owner 林春木
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