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Degradable self-expandable esophageal stent and preparation method thereof

A self-expanding, esophageal technology, applied in the field of medical devices, to achieve the effects of no toxic side effects, broad application prospects, and enhanced treatment and diagnosis

Inactive Publication Date: 2011-04-06
苏州同科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a degradable self-expanding esophageal stent and its preparation method, which solves many problems of metal stents used in esophageal interventional treatment at present, and enhances the diagnosis and treatment of esophageal diseases by coating drugs and / or X-ray contrast agents. Treatment and Diagnosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation of degradable self-expanding esophageal stent

[0028] Take polylactic acid (molecular weight: 250,000) with a total mass of 80%, add a nucleating agent with a total mass of 1% after drying, and mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm. Mixed raw materials; under the conditions of extrusion temperature of 160°C, screw speed of 30 rpm, feeding speed of 2.0kg / h and traction speed of 1m / s, the mixed raw materials are melted and extruded through an extruder to obtain a degradable material with a diameter of 0.3mm. Filaments, degradable filaments are used to weave mesh esophageal stents on a mold of a certain shape, the external diameter of the stent is 30mm, and the length is 100mm; 9% paclitaxel is made into 0.10g / ml solution, immerse the net-like support in the solution, take out the net-like support and make the dichloromethane evaporate quickly to dryness, and finally use ethylene peroxide to fumigate and ste...

Embodiment 2

[0029] Example 2 Preparation of degradable self-expanding esophageal stent

[0030] Get 50% polylactic acid (molecular weight is 250,000) of total mass and 30% polycaprolactone (molecular weight is 70,000) of total mass, add the nucleating agent of 1% total mass after drying, at 40 ℃ temperature and 300 Mix the raw materials in a mixer under the condition of rotation speed per minute to obtain the mixed raw materials; under the conditions of extrusion temperature of 160°C, screw speed of 30 rotations per minute, feeding speed of 2.0kg / h and traction speed of 1m / s, the mixing The raw materials are melted and extruded by an extruder to obtain degradable filaments with a diameter of 0.3 mm, and the degradable filaments are used to weave a mesh esophageal stent on a mold of a certain shape. The external diameter of the stent is 25 mm and the length is 80 mm; The polylactic acid (molecular weight is 150,000) of total mass 10% and the X-ray developing agent of total mass 9% are made...

Embodiment 3

[0031] Example 3 Preparation of degradable self-expanding esophageal stent

[0032]Get polylactic acid (molecular weight is 250,000) of total mass 50% and polycaprolactone (molecular weight is 70,000) of total mass 21%, add the plasticizer of total mass 10% after drying, at 40 ℃ of temperature and 300 Mix the raw materials in a mixer under the condition of rotation speed per minute to obtain the mixed raw material; under the conditions of extrusion temperature of 170°C, screw speed of 35 rotations per minute, feeding speed of 3.0kg / h and traction speed of 0.5m / s, the The mixed raw materials were melted and extruded by an extruder to obtain degradable filaments with a diameter of 0.8mm, and the degradable filaments were used to weave a mesh esophageal stent on a mold of a certain shape, with an outer diameter of 35mm and a length of 120mm; Quality 10% degradable polyurethane (molecular weight is 80,000) and total mass 9% paclitaxel are made into 0.10g / ml solution, will have net...

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PUM

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Abstract

The invention relates to the technical field of medical appliances, and in particular discloses a degradable self-expandable esophageal stent and a preparation method thereof. The degradable self-expandable esophageal stent is characterized in that: the degradable self-expandable esophageal stent has anticancer and developing effects and is obtained by mixing a degradable polymer and other auxiliary agents uniformly to obtain a mixture, melting and extruding the mixture by using an extruder to obtain degradable filaments, weaving the degradable filaments into a mesh esophageal stent on a mould which has a certain shape, and performing film-coating treatment on the stent. The degradable self-expandable esophageal stent not only overcomes the shortcomings of a metal stent, but also reinforces the treatment and the diagnosis of esophageal diseases by coating an anti-cancer medicament or an X-ray developing agent, so the degradable self-expandable esophageal stent has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a degradable self-expandable esophageal stent and a preparation method thereof. Background technique [0002] Interventional therapy is to make a small channel with a diameter of a few millimeters on the blood vessel or skin or pass through the original pipeline of the human body without exposing the lesion by surgery. The minimally invasive treatment method that treats the lesion locally under the guidance of the patient. Interventional therapy is an emerging treatment method between surgery and medical treatment, including endovascular intervention and non-vascular interventional therapy, among which esophageal stent belongs to non-vascular interventional therapy, it is to solve benign and malignant esophageal stricture and various esophageal fistula, For the repair of esophageal and tracheal fistula, esophageal stent placement has the advantages of less tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14A61L31/16A61F2/90
Inventor 任天斌黄超李建波刘秋明贾梦虹
Owner 苏州同科生物科技有限公司
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