Bionic nerve graft used for peripheral nervous recovery and preparation method thereof

A technology for peripheral nerve and nerve transplantation, applied in the field of bionic nerve grafts and its preparation, can solve problems such as poor repair of nerve conduits, and achieve good cell affinity and mechanical properties
CN106729980AActive Publication Date: 2017-05-31TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2017-05-31

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Abstract

The invention relates to a bionic nerve graft used for peripheral nervous recovery and a preparation method and application thereof. The bionic nerve graft comprises a chitosan film conduit and a fibrous protein hydrogel beam positioned in the chitosan film conduit, wherein the fibrous protein hydrogel beam is prepared from fibrous protein through an electrospinning technique. The bionic nerve graft prepared by the preparation method is formed by the filling of the chitosan film conduit and the fibrous protein hydrogel beam of a multi-stage orientation structure, wherein a nerve regrowth space is effectively supported by a chitosan film, the orientational regeneration of a nerve axon is effectively guided by the fibrous protein hydrogel beam of multi-stage orientation, the cell affinity and the mechanical property of whole materials are good, and in addition, degrading speed and the repairing speed of peripheral nervous tissues are matched.
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Description

technical field

[0001] The invention relates to the technical field of biomedical materials, in particular to a bionic nerve graft for repairing peripheral nerves and a preparation method thereof. Background technique

[0002] The repair of nerve injury is a series of complex pathological processes. The slow nerve regeneration process, the formation of scar tissue, the generation of inhibitory microenvironment, the degeneration of motor terminal tissue and function all restrict the repair of damaged nerve. Small-segment nerve defects can be restored by the nerve's self-repair ability. The repair and functional reconstruction of long-segment nerve defects is still a clinical problem in neurosurgery, which seriously affects the health status and quality of life of patients.

[0003] Nerve stump anastomosis and nerve conduit bridging are often used in surgical operations for the regeneration of damaged nerves. The former is suitable for small nerve injuries, and the treatment ...

Claims

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