Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Hydrophobia vaccine freezing drying preparations for stable human beings and the preparations thereof

A technology of rabies vaccine and freeze-dried preparation, which is applied in the field of freeze-dried preparation of human rabies vaccine and its preparation, to achieve the effects of preventing rabies, reducing the incidence of side effects, and reducing costs

Active Publication Date: 2008-01-02
LIAONING CHENGDA BIOTECH
View PDF2 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on replacing the routinely used human serum albumin stabilizer in rabies vaccine preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A phosphate buffer system with a pH of 7.2 is used, the concentration of sodium chloride is 0.8%, then 2% trehalose, 2% sucrose, and 3% dextran are added to make the freeze-drying excipient, and then 0.1-0.2 um filter membrane to filter and sterilize, then add inactivated rabies virus antigen (derived from pv2061 strain) to 12IU / ml, mix well and divide into 0.5ml preparations per bottle, freeze-dry to make human serum albumin-free The lyophilized preparation of rabies vaccine was used to determine the immune potency of the preparation.

Embodiment 2

[0020] According to Example 1, 1% maltose was used instead of trehalose, and 3% dextran was used instead of dextran as excipients to prepare a freeze-dried preparation of rabies vaccine without human serum albumin, and its immune potency was determined.

Embodiment 3

[0022] According to Example 1, 3% gelatin was used instead of trehalose to prepare a freeze-dried preparation of rabies vaccine without human serum albumin, and its immune potency was determined.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a kind of hydrophobia vaccine for human, which in detail relates to a freeze-drying hydrophobia vaccine for human and its preparation method. It is contained in physiological soluble buffer solution with pH being 7-8, the sodium chloride weight proportion is 0.4-1.0%, one or several from mycose, sucrose, gelatin, maltose and dextran is used as stabilizing agent, the concentration is 0.5-5%; the weight proportion of shaping agent for freeze-drying agent is 1-5%, and the purified hydrophobia viral antigen concentration is 4-20 IU per ml.

Description

technical field [0001] The invention relates to a human rabies vaccine preparation, in particular to a freeze-dried human albumin-free, compatible and storage-stable rabies vaccine preparation and its preparation. Background technique [0002] Rabies vaccine is the application of cell culture engineering to cultivate and harvest rabies virus. After special purification and inactivation, a certain concentration of human albumin is added to make various liquid and freeze-dried preparations. It is a kind of vaccine used for prevention and treatment. Immunization vaccines after exposure to rabies virus can effectively stimulate the body to produce anti-rabies virus antibodies and prevent rabies clinically. [0003] Stable rabies vaccine preparations have corresponding products on the market at home and abroad, which all contain human serum albumin as a stabilizer, and the use of human serum albumin as a stabilizer complicates the production process. As a blood product, human ser...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/205A61K9/19A61P31/14
Inventor 杨旭高军查力白珠穆李旭侯剑英杨俊伟
Owner LIAONING CHENGDA BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com