50results about How to "Low side reaction rate" patented technology

The invention relates to a vascular targeting embolism sustained release agent of a triple compound microsphere for an antituberculosis drug, a preparation method and applications thereof. The sustained release agent comprises a carrier and a drug, wherein the drug is encapsulated by the carrier, the carrier is selected from sodium alginate or chitosan, and the drug is a triple compound antituberculosis drug which comprises rifampin, isoniazide and pyrazinamide or moxifloxacin. Three antituberculosis drugs are employed as matrixes of a drug solution, sodium alginate or chitosan is used as a carrier solution, and a prepared solution is obtained by mixing the drug solution and the carrier solution. A polymer solution having the drug is enabled to be dispersed into droplets with certain particle sizes and to be sprayed into a curing liquid through a method of high voltage electrostatic droplets, and thus the microsphere for the antituberculosis drug are prepared in the presence of calcium ions. The embolism sustained release agent can be used in the drug for treating pulmonary tuberculosis, pulmonary tuberculosis massive hemoptysis, cavitary pulmonary tuberculosis, renal tuberculosis, osteoarticular tuberculosis, genital tubercolosis, thyroid tuberculosis, tuberculosis of cervical lymph nodes, pericardial tuberculosis, chest-wall tuberculosis and other in-vivo tuberculosises.

The invention relates to a cefoxitin sodium medicinal composition, powder injection and a preparation method thereof. The medicinal composition consists of cefoxitin sodium, histidine and hydroxypropyl-beta-cyclodextrin, wherein the weight of the histidine is 3 to 8 percent of that of the cefoxitin sodium, and the weight of the hydroxypropyl-beta-cyclodextrin is 5 to 10 percent of that of the cefoxitin sodium. The medicinal composition is high in stability, related medicament content of the medicinal composition is further lower than that of a commercial cefoxitin sodium product, gastrointestinal side effect is low, the quality of the medicaments is greatly promoted, and the safety of the medicaments is improved.

The invention provides a polymer micro negative pressure pyrolysis method for waste tires. Specifically, in the present invention, block tires are directly pulverized in two stages, and the pulverized materials are injected into the microporous plate in the kettle body through the embedded tube of the reaction kettle, and then the kettle body is closed, and firstly, it is crushed at a low speed under a slight negative pressure condition. Raise the temperature to about 120°C, keep it for a period of time, then turn it into a deep negative pressure, and raise the temperature to 450°C at a relatively high speed, and carry out nitrogen protection, and then carry out continuous pyrolysis under reduced pressure conditions, and the pyrolyzed oil can be in Under pressure, it is discharged downward through the microporous plate, while the solid phase remains on the microporous plate. After drying and grinding, the existing metal wires in the tire exist in the form of particles or flakes, which can be removed by sieving . By applying the present invention, the whole process of tire crushing, pyrolysis and material collection can be completed in a consistent manner, and the stripping link of metal wires can be omitted, thereby obviously improving the continuity and process efficiency of the pyrolysis process.

The invention discloses a preparation method of 2,5-furandicarboxylic acid under mild conditions. The preparation method comprises: making a mixed reaction system comprising 5-hydroxymethylfurfural and / or 5-hydroxymethylfurfural derivatives, hydrogen peroxide, catalyst, hydrogen peroxide stabilizer, alkali and water at 0-80 ℃ for 1-24 hours to prepare 2,5-furandicarboxylic acid, and the pH value of the mixed reaction system is 7-13. The method provided by the invention is carried out in an aqueous phase, using a non-noble metal catalyst, hydrogen peroxide as an oxygen source, and adjusting the pH value and adding a hydrogen peroxide stabilizer to prepare 2,5-furandicarboxylic acid with high yield under mild conditions. The method provided by the invention is green and pollution-free; the operation is convenient and the process is simple; the conversion rate of reactants and the selectivity of product 2,5-furandicarboxylic acid are both high.

The invention relates to a kind of hydrophobia vaccine for human, which in detail relates to a freeze-drying hydrophobia vaccine for human and its preparation method. It is contained in physiological soluble buffer solution with pH being 7-8, the sodium chloride weight proportion is 0.4-1.0%, one or several from mycose, sucrose, gelatin, maltose and dextran is used as stabilizing agent, the concentration is 0.5-5%; the weight proportion of shaping agent for freeze-drying agent is 1-5%, and the purified hydrophobia viral antigen concentration is 4-20 IU per ml.