7 results about "Rabies Virus Antigen" patented technology

The present invention provides immunogenic compositions comprising a secreted fusion protein, wherein the secreted fusion protein comprises a soluble influenza or rabies virus antigen linked by in-frame fusion to a collagen C-terminal portion capable of self-trimerization to form a disulfide-linked trimeric fusion protein. The present invention also provides uses of the immunogenic compositions for generating an immune response against influenza or rabies infection and for use in vaccine compositions. The present invention also provides methods of producing recombinant peptides and proteins, methods of prevention, treatment, and / or diagnosis, and related kits.

This invention relates to the field of veterinary vaccines, specifically to a porcine pseudorabies virus antigen, a porcine pseudorabies subunit vaccine, its preparation method, and its application. The porcine pseudorabies virus antigen of this invention is the porcine pseudorabies virus gD protein, and the amino acid sequence of the porcine pseudorabies virus gD protein is shown in SEQ ID NO:1. The porcine pseudorabies subunit vaccine prepared using the porcine pseudorabies virus antigen has a simple preparation method, high neutralizing antibody value, and strong antigenic immunogenicity. It can effectively activate the body's immune response and provide excellent immunoprotection against porcine pseudorabies.

Provided herein are varicella-zoster virus vaccine, human papilloma virus vaccine, and rabies vaccine antigens, compositions thereof, and uses thereof in cancer immunotherapy and treatment of cancer.

Provided herein are varicella-zoster virus vaccine, human papillomavirus vaccine, and Rabies vaccine antigens, compositions thereof, and uses thereof in cancer immunotherapy and cancer treatment.

The invention belongs to the technical field of biology, and discloses a replication-deficient CAV2 recombinant virus for expressing a rabies virus ERA-G antigen gene, and the replication-deficient CAV2 recombinant virus is a recombinant canine type 2 adenovirus and is preserved in China Center for Type Culture Collection; the preservation date is March 13, 2024; the preservation number is CCTCC (China Center For Type Culture Collection) NO: The preservation address is Wuhan University, Wuhan, China. The recombinant virus has a good protection effect, is particularly suitable for nasal drip and intramuscular injection combined immunization, and can be efficiently rescued, propagated and passaged in a specific cell line. Meanwhile, the invention also provides a rescue method, a passage or propagation method and a vaccine of the recombinant virus as well as another replication-defective CAV2 recombinant virus and application of the replication-defective CAV2 recombinant virus.

This invention concerns molecular markers based on nucleotide and amino acid substitutions in the nucleoprotein and glycoprotein genes of the Indonesian rabies virus that are used for variant identification and antigenicity evaluation. These molecular markers are obtained through analysis of specific changes in the nucleotide and amino acid sequences in the N and G genes of the Indonesian natural strain of rabies virus by comparing them to reference sequences. The identified substitutions are used as a basis for distinguishing rabies virus variants, mapping genetic variations between isolates, and evaluating potential differences in the antigenic properties of the rabies virus. These molecular markers can be applied in molecular surveillance activities, monitoring the evolution of the rabies virus, and as a basis for evaluating antigenic compatibility with reference strains or rabies vaccine strains.This invention provides a more specific and efficient approach in the genetic characterization of the Indonesian rabies virus compared to previous methods that have not utilized nucleotide and amino acid substitution markers in an integrated manner.

To provide a vaccine for rabies virus.SOLUTION: Provided is an immunogenic composition comprising an alphavirus RNA replicon particle encoding a rabies virus antigen.SELECTED DRAWING: None