Biological and haemostatic wound dressing and preparation method thereof

A hemostatic dressing and biological technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems of not meeting clinical requirements, unsatisfactory retention time, etc. Effect

Inactive Publication Date: 2012-07-18
山东省医疗器械研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The natural hyaluronic acid or its salt used in this invention has not undergone any cross-linking, and the natural hyaluronic acid is easily degraded by enzymes in body tissues, and its good water solubility makes it easy to be diffused in tissues, so it is in animal tissues The local retention time is not satisfactory and cannot meet the clinical requirements of 10-20 days for wound healing

Method used

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  • Biological and haemostatic wound dressing and preparation method thereof
  • Biological and haemostatic wound dressing and preparation method thereof
  • Biological and haemostatic wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1, the preparation of biological hemostatic dressing

[0045] The biological hemostatic dressing is prepared by the method of the present invention, comprising the following steps:

[0046] 1) Preparation of cross-linked gel: 1 g of a specific substance A, carboxymethyl cellulose, was added to 99 ml (g) of water (1:99) to obtain an aqueous solution of carboxymethyl cellulose with a mass concentration of 1%. 3 hours to dissolve or swell, adjust the aqueous solution to pH 4-6 with 0.1N HCl; then mix 30 mL of carboxymethyl cellulose aqueous solution with 1 mL of a specific B substance mass concentration of 10% aluminum chloride solution (mixing ratio 30:1), after mixing, place at room temperature for 2 hours until it is cross-linked into a water-insoluble gel; neutralize the gel with 0.2N aqueous sodium hydroxide solution to neutral pH, and wash with distilled water 3 times, funnel filtration, and the cross-linked gel was obtained after removing the filtrate. ...

Embodiment 2-10

[0049] Embodiment 2-10, the preparation of biological hemostatic dressing

[0050] Different biological hemostatic dressings were prepared by the same method as in Example, with the changes listed in Table 1:

[0051] Table 1: Optimized ratio of biological hemostatic dressings

[0052]

[0053] Note: Instructions for high esterified pectin:

[0054] Pectin with an esterification degree greater than 50% is high-esterification pectin; pectin with an esterification degree less than 50% is low-esterification pectin. High-esterified pectin means that more than half of the carboxyl groups in high-methoxy pectin exist in the form of methyl esterification (-COOCH3), and the remaining carboxyl groups exist in the form of free acid (-COOH) and salt (-COONa).

[0055] The structure of pectin is

[0056]

[0057] Manufacturers: Guangzhou Jianke Biotechnology Co., Ltd., Guangdong Xinyuehai Commercial Development Co., Ltd., Quzhou Pectin Co., Ltd., Guangzhou Yexing Trading Co., Ltd...

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Abstract

The invention discloses biological and haemostatic wound dressing and the preparation method thereof. The biological and haemostatic wound dressing provided by the invention is water-insoluble gel formed through cross linking after mixing water solution of high molecular compound containing carboxyl as well as environment-friendly ion cross-linking agent, and then the water-insoluble gel is placed into a refrigerator tray and a product is obtained after freezing, drying and suppressing are carried out sequentially. Experiment prove that the biological and haemostatic wound dressing provided by the invention has a better adhesive effect on wound surfaces and bleeding, is less susceptible to dropping off from the wound surfaces, and has an obvious hemostatic effect. The biological and haemostatic wound dressing expands rapidly after partly absorbing body fluid and becomes the gel to play the insulating and expanding effect, thereby having excellent haemostatic and anti-adhesion effects.

Description

technical field [0001] The invention relates to a biological hemostatic dressing for medical use and a preparation method thereof, in particular to a biological hemostatic dressing with functions of hemostasis, anti-adhesion, degradable in vivo and a preparation method thereof. Background technique [0002] Extensive bleeding and oozing during surgery is a frequent problem encountered by surgeons. Bleeding or oozing of blood is unavoidable when performing surgery on organs with rich blood supply, especially in multivascular solid organs (such as traumatic hemorrhage of liver and spleen). Bleeding from surgical wounds can be caused by local factors and systemic factors. The former can be caused by arterial, venous, or capillary bleeding, and the latter can be caused by insufficient platelet function, coagulation dysfunction, or excessive fibrinolytic activity. Liver transplantation bleeding is caused by mixed factors and coagulation disorders. Immediate results can sometime...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42C08J3/075C08J3/24
Inventor 李红梅赵成如郈秀菊
Owner 山东省医疗器械研究所
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