Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof

A technology of carboxymethyl chitosan sponge and carboxymethyl chitosan, applied in absorbent pads, medical science, bandages, etc., can solve the problems of environmental impact, easy residual toxicity, etc., and achieve accurate hemostatic effect and hemostatic effect , the effect of improving safety

Active Publication Date: 2005-09-21
上海美宝生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, chitosan sponges were prepared using acidic solutions, which easily affected environmental protection, and the aldehyde crosslinking agents used were prone to residual toxicity

Method used

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  • Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof
  • Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Add 100ml of 1% carboxymethyl chitosan aqueous solution, add 1.0g of 100 mesh chitin powder and 1ml of glycerin, mix well at 50°C, foam at room temperature for 30 minutes, add 15ml of 1% aluminum chloride solution at the same time for crosslinking, and then Put it into the mold and fully freeze it at -20°C. After taking it out, it was unmoulded and immediately freeze-dried for 24 hours. The resulting sponge body was cut to the desired size.

Embodiment 2

[0021] 100ml of 2% carboxymethyl chitosan aqueous solution, add 2g of 100 mesh chitin powder and 5ml of glycerin, mix well at 50°C, foam at room temperature for 30 minutes, add 1ml of 20% aluminum chloride solution for cross-linking, and then pack Pour into molds and freeze at -20°C for 24 hours. After taking it out, it was unmoulded and immediately freeze-dried for 24 hours. The resulting sponge body was cut to the desired size.

Embodiment 3

[0023] 100ml of 2% carboxymethyl chitosan aqueous solution, add 0.5g of 100 mesh chitosan powder and 1ml of glycerin, foam for 30 minutes, add 5ml of 1% calcium chloride solution at the same time, then put it into a mold, freeze at -20°C for 24 Hour. After taking it out, it was unmoulded and immediately freeze-dried for 24 hours. The resulting sponge body was cut to the desired size.

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PUM

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Abstract

The invention relates to a method for producing a water-absorbing swellable carboxymethyl chitosan sponge and its application, which comprises: adding a little chitosan powder or chitosan powder into the carboxymethyl chitosan solution with a quantitation of glycerin as the elasticizer, making every 100 ml solution with carboxymethyl chitosan of 1-5 g, chitosan powder or chitosan powder of 0.5-2 g and glycer of 1-5 g, stirring to foam and adding the environment-friendly ion-cross linker to cross-linking completely, cooling and drying to get the production. In the invention, using water-soluble materials as raw materials to avoid contamination, and using non-aldehyde group ion-cross linker to avoid residual toxicity of aldehyde group.

Description

1. Technical field: [0001] The invention relates to a novel biological sponge, specifically a soluble, degradable and water-absorbing-swellable sponge prepared from carboxymethyl chitosan as a main raw material, as well as its preparation method and application. 2. Background technology: [0002] At present, in my country's medical market, more than 30 kinds of medical sponge products are widely used in surgical hemostasis, cavity hemostasis and wound healing treatment. They are mainly made of gelatin, collagen and other materials, because the raw materials are foreign proteins, which are stored in the human body and easily cause immunogenic reactions. Chitosan is a natural biological material, which can be degraded into safe and non-toxic glucosamine in the human body, and will not cause immunogenic reactions, so it has excellent biocompatibility; at the same time, chitosan is the only Positively charged glucosamine, because of its unique physical and chemical structure, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42C08L5/08
Inventor 商庆新金箭飞易智强
Owner 上海美宝生命科技有限公司
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