45results about How to "Removal without secondary surgery" patented technology

The invention relates to a 3D-printed porous tantalum metal bone plate. The 3D-printed porous tantalum metal bone plate is characterized in that tantalum metal powder is taken as a base material, andthe bone-imitating trabecular bone plate having bone induction property and produced by 3D printing has an interconnecting-pore structure fit for bone growth. The production method includes: under argon production, using medical grade spherical tantalum powder as a raw material to produce the porous bone plate by 3D printing; removing excess metal powder adhering to the surface of the bone plate through sandblasting; removing residual stress through heat treatment to make the surface of the bone plate smooth. By the arrangement, the porous bone plate with the bone induction property can form excellent bone integration with bone tissue so as to achieve permanent fixation in biology.

The invention belongs to the technical fields of macromolecule materials and biomedical engineering, in particular to a method for constructing a composite structure tissue engineering bracket containing different extracellular matrixes. The method comprises the following steps: preparing a blood vessel bracket by an electrostatic spinning method; preparing a poriferous bracket part by adopting a blend of polylactic acid and polycaprolactone through a hot-pressing and salting-out method; and introducing the blood vessel bracket into the poriferous bracket. The composite structure tissue engineering bracket constructed in the invention realizes that different extracellular matrixes are constructed in a same bracket.

The invention discloses a degradable pure magnesium metal osteosynthesis plate for long bone fractures of extremities, which comprises a long bone plate body and a through hole provided on the bone plate body, and the through hole includes a threaded circular locking hole and a strip-shaped pressure hole, the pressure hole is located in the center of the body, the locking holes are symmetrically distributed on both sides of the pressure hole, and the upper surface of the bone plate body is provided with rib protrusions , the locking hole and the pressurizing hole are located on the inner side of the protrusion of the reinforcing rib, and the two sides of the bone plate body are respectively fixedly connected with side wings protruding outward, and the side wings are provided with screw fixing holes. The upper surface of the bone plate body of the present invention is provided with a ring of reinforcing ribs, which strengthens the biomechanical properties of the degradable magnesium metal and prevents it from breaking. The bone plate can be better attached to the bone surface, has a pressurizing effect, and has a better holding and fixing effect on the fracture.

The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.

The invention discloses a bionic bone joint based on curved surface 3D printing and a preparation method thereof. The multilayer bionic joint is formed by an inner layer, a middle layer and an outer layer which are in close contact in sequence, wherein the inner layer is a porous tantalum metal support, the middle layer is a solid biological ceramic support, the outer layer is a solid gelatin/ sodium alginate composite hydrogel support, the inner layer, the middle layer and the outer layer are all of an arc-shaped shell structure, the radian of the arc-shaped shell is 120-240 degrees, and a cell loading cavity formed by continuous or discontinuous edges formed by protruding outwards from the surface of the outer layer and grooves formed between the edges is formed in the surface of the outer layer. The multilayer bionic joint is large in arc surface radian and suitable for repairing large-area osteochondral joint defects, and the repairing area can be larger than 1/2 of the area of thewhole joint. Cells are inoculated into the cell loading cavity, so that the adhesion rate of the cells is increased, and the problem that the surface of the outer layer of the bionic joint is smooth,so that the inoculated cells are not prone to adhesion is solved.

The invention provides an oral guided bone regeneration and repair system and a preparation method thereof, and belongs to the technical field of oral implantation. The oral guided bone regeneration and repair system comprises a bone filling support, a barrier film and bone cell growth guiding fibers, wherein the barrier film comprises a first arc-shaped surface and a second arc-shaped surface which are oppositely arranged in the thickness direction of the barrier film, and the first arc-shaped surface corresponds to a bone defect area of an oral cavity to be repaired; the bone filling supportis arranged on the first arc-shaped surface, and the bone cell growth guiding fibers are arranged on the bone filling support in a winding mode according to the preset orientation so as to guide directional growth of bone cells in the bone defect area. The oral guided regeneration and repair system provides enough space for growth of bone cells, has the capacity of resisting bacterium breeding and the characteristic of being completely degradable and absorbable, does not need to be taken out through a secondary operation, can also accelerate the bone growth speed, can shorten the treatment time of an oral cavity bone defect patient, and can improve the postoperative recovery probability of implantation.

The invention belongs to the field of medicine bioengineering and particularly relates to a drug composition containing glutathione (GSH) and an application of the drug composition. More particularly, the invention provides an application of reduced GSH to preparation of drugs for promoting diabetic implant bone integration, and further provides the drug composition containing GSH. The drug composition can promote diabetic implant bone integration and comprises GSH and other drugs, wherein the other drugs are preferably selected from resveratrol and/or insulin. Furthermore, the invention provides a drug preparation containing the drug composition and a preparation method of the drug preparation; the drug preparation is preferably selected from sustained-release microspheres.

The invention discloses a preparation method for a natural basin-based bionic structure bone scaffold. Silk protein and wool protein are taken as main raw materials, a silk protein solution and glycerinum are uniformly mixed according to the mass ratio of 60-120:20-60 and injected in a bone scaffold mold, a wool keratin solution is slowly injected into the mixed solution, and then through -40--20DEG C freezing and -72-5 DEG C vacuum freezing drying under 1.0*105-1.0 Pa, the silk protein/wool keratin bionic bone scaffold material is obtained. The prepared scaffold material is similar to the autogenous bone structure, the porosity rate reaches 70-95%, the hole diameter is uniform in distribution, the outer layer is compact, the hole diameter is smaller, the diameter range is 30-150 microns,the scaffold material has certain mechanical supporting performance, the diameter of inner holes is larger, the diameter range is 250-600 microns, and the scaffold material is suitable for migration,dependence and proliferation of cells.

The invention provides an orthopedic internal fixation plate. The cross section on one side contacted with the backbone is an arc matched with the backbone, and the orthopedic internal fixation plate is made of PLLA or composite material of PLLA and HA. A preparation method for the orthopedic internal fixation plate comprises the following steps: a) manufacturing a die, and enabling the cross section of the orthopedic internal fixation plate on the one side contacted with the backbone to be the arc matched with the backbone; and b) putting a biodegradable polymer material into the die, and performing compression molding. The orthopedic internal fixation plate has a shape of a certain radian matched with the backbone aiming at the structure of the backbone of a human body, and can be effectively attached to the shape of the vertebral column, reconstruct and recover the stability of the vertebral column, prevent adhesion and slipping displacement, and relieve the pain of patients; and the orthopedic internal fixation plate made of the biodegradable polymer material has good biocompatibility and abrasion resistance, can be retained in the human body for long term, finally can be fully biodegraded, and does not need to be taken out through a secondary operation.

The invention discloses a degradable zinc alloy anastomotic apparatus and a preparation method thereof. The degradable zinc alloy anastomotic apparatus uses a degradable Zn-Li-Mn-Y alloy as a material, and the degradable Zn-Li-Mn-Y alloy includes the following components: 0-1 wt.% of Li, 0-1 wt.% of Mn and 0-1 wt.% of Y, without including 0, and the rest are Zn and unavoidable impurities. The degradable zinc alloy anastomotic apparatus includes any one of absorbable suture, medical zipper, anastomotic nail, anastomotic ring, anastomotic clip, anastomotic cannula or vascular clamp. The degradable zinc alloy anastomotic apparatus of the invention is excellent in mechanical properties, simple and convenient in operation, firm in anastomosis, capable of being decomposed in tissues or organs, capable of being fully absorbed by tissues and high in tissue compatibility.

The invention provides a composition for preventing osteoporotic compression fractures, and a preparation method thereof. The composition comprises bone cement and allogeneic bone according to a mass ratio of 1:3 to 3:1. The composition can be used in a vertebral body reinforcement filler, reserves the three-dimensional grid structure of natural bone tissues, and has good cell compatibility and bone conduction effects; bone cells in the allogeneic bone grow in vertebral body marrows to realize uniform sclerotin and firm combination, so the adjacent segment endplate stress after vertebral body reinforcement operation is reduced, and adjacent vertebral body fractures are avoided; and adherence growth and gene expression of the bone cells are finally completely substituted by creeping, so the composition injected to the vertebral body does not cause vertebral body height loss and permanently becomes human body bone tissues after bone healing, and secondary operation removal is prevented.

The invention provides a mold for preparing a degradable joint balloon and a use method thereof. During using, a degradable polymer solution is prepared first; the prepared degradable polymer solutionis injected into a forming cavity of a combined mold through any runner; after the degradable polymer solution is solidified, a first external mold and a second external mold are detached to obtain afirst mold release product; dissolving a soluble internal mold in the first mold release product to obtain a second mold release product; changing clean water to clean the second mold release productfor multiple times; and after the second mold release product is dried, a degradable balloon can be prepared, wherein the degradable balloon is prepared by using a degradable polymer material with good biocompatibility, can be gradually degraded in vivo and absorbed by human body within 2-18 months, can have a supporting and stress buffering effect, cannot obstruct the repairing of normal tissuesand does not need to be taken out through second operation.

The invention relates to an absorbable rib fixing plate, and belongs to the technical field of medical supplies. A key point of the technical scheme is the absorbable rib fixing plate, the absorbablerib fixing plate includes an absorbable bone plate, an absorbable support plate and an absorbable screw; and the absorbable bone plate and the absorbable support plate are all in arc shape and matchedwith ribs, and the absorbable bone plate is provided with a plurality of connecting holes, a plurality of threaded holes corresponding to the connecting holes are formed in the absorbable support plate, after the absorbable screws penetrate through the connecting holes and the ribs, and the absorbable screws are matched with the threaded holes in a threaded mode so as to improve supporting and shaping effects on fractured ribs.

The invention discloses a subcutaneous soft tissue stitching instrument and a degradable metal stitching nail. The subcutaneous soft tissue stitching instrument comprises a nail pushing mechanism, a nailing mechanism and a nail storage cabin mechanism, the nail pushing mechanism comprises a supporting plate, a top plate, a nail pushing plate reset spring, a pressing block and a nail pushing plate, and the top plate is arranged at the top end of the supporting plate; the top plate is connected with the top face of the pressing block fixing end through a nail pushing plate reset spring, the nail pushing plate is slidably arranged on the supporting plate, and the end face of the pressing block fixing end is fixed to the top end of the side face of the nail pushing plate. The nailing mechanism comprises a nailing track used for containing suturing nails, and the nailing track is arranged at the bottom end of the nail pushing plate. And the nail storage cabin mechanism can continuously push the suturing staples into the nailing track. The effects of continuous nailing and rapid nailing are achieved through the nail pushing mechanism and the nail storage cabin mechanism, the suturing time of muscles or subcutaneous tissues is effectively saved, and surgical trauma and infection risks are effectively reduced; the suturing nail is made of biodegradable magnesium alloy or zinc alloy, can be automatically degraded and absorbed in vivo, and has no adverse side effect.