The present invention relates to a high strength nickel base corrosion resistance alloy, which has the following components, by mass, 0.06-0.10% of C, less than or equal to 1.0% of Si, less than or equal to 1.50% of Mn, 19.0-23.0% of Cr, less than or equal to 0.035% of P, less than or equal to 0.001% of S, less than or equal to 0.020% of N, 29.0-35.0% of Ni, 0.15-0.6% of Ti, 0.15-0.6% of Al, 0.001-0.005% of Mg, less than or equal to 0.5% of Cu+O, and the balance of Fe and unavoidable impurities. The nickel base corrosion resistance alloy has a fully austenite structure, and forms MgO and/or MgO.Al2O3 particles with a diameter of about 10 nm-1 mum and a number of 30-50/mm<2> in a liquid alloy so as to refine the diameter of the initial solidified grains of the alloy continuous casting billet to about 0.5-1.0 mm. In addition, a vertical continuous casting process is adopted to produce, such that surface cracks of the continuous casting billet are avoided; and the grain size of the final product is controlled to the 3.5-4 level, such that the product has characteristics of excellent mechanical property, excellent high temperature creep resistance, and the like, and is suitable for manufacture of parts of furnace devices, heat exchangers, steam-powered turbines, and the like.