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Personalized 3D printing porous titanium-based tantalum-coating bone fracture plate and preparation method thereof

A 3D printing, porous titanium technology, applied in the direction of outer plate, internal bone synthesis, medical science, etc., can solve the problems of shape mismatch, secondary extraction, stress shielding, etc., to avoid stress shielding, improve biological activity, and good plasticity Effect

Active Publication Date: 2019-08-06
赵德伟 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims at the above-mentioned traditional metal bone plate having many disadvantages in material properties, infection and aseptic loosening caused by the release of toxic metal ions, stress shielding, secondary removal, shape mismatch, etc., and researches and designs a 3D printing technology. Fabrication of porous titanium-based bone plate and tantalum coating, the bone plate can be personalized, permanent implantation, avoid stress shielding, have high histocompatibility and biomechanical properties, and can induce bone tissue generation

Method used

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  • Personalized 3D printing porous titanium-based tantalum-coating bone fracture plate and preparation method thereof
  • Personalized 3D printing porous titanium-based tantalum-coating bone fracture plate and preparation method thereof
  • Personalized 3D printing porous titanium-based tantalum-coating bone fracture plate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A personalized 3D printed porous titanium-based tantalum metal-coated bone plate with osteoinductive activity, which uses titanium metal powder as a substrate, and a porous titanium-based bone plate with a void structure made by 3D printing is formed with a tantalum coating. The layer is prepared.

[0048] Such as figure 1 with figure 2 As shown, the porous titanium-based bone plate includes a main body, and the main body includes an outer reinforcing rib located on the peripheral edge of the main body, an inner reinforcing rib located inside the outer reinforcing rib, a void structure, and a screw hole. The outer reinforcing ribs are in a continuous structure to form the edge of the body, and the inner reinforcing ribs are in a mesh structure to improve the mechanical strength of the bone plate. The void structure is distributed between the outer reinforcement ribs, the inner reinforcement ribs and the screw holes, and is composed of internally connected diamond-shaped p...

Embodiment 2

[0052] Using high-purity titanium powder (spherical powder, particle size 15μm-30μm) as raw material, it is processed and manufactured by 3D printing to prepare personalized 3D printed tantalum metal coated porous titanium bone plate, which specifically includes the following steps:

[0053] (1) Understand the anatomical structure of the patient's fracture through CT scan, and reconstruct the CT scan data into a 3D model (ie 3D geometric image);

[0054] (2) Use Auto CAD, Pro E, Magics software to design the shape and void structure of the personalized bone plate, and obtain the three-dimensional geometric model of the porous target bone plate (such as figure 2 Shown) to further obtain the .stl format file of the three-dimensional geometric model of the porous target bone plate;

[0055] (3) such as figure 2 The 3D printing process of the porous bone plate shown is: merge the titanium metal parameter package with the .stl file on the Building Processing interface to obtain the .mtt ...

Embodiment 3

[0066] A male goat weighing about 20kg was selected as the experimental animal, and the anatomical structure of the goat's tibia was understood through CT scan, and the CT scan data was reconstructed into a 3D model (ie, geometric image). Use Auto CAD, Pro E, Magics software to design the shape and void structure of the personalized bone plate, obtain the three-dimensional geometric model of the porous target bone plate, and further obtain the .stl format file of the three-dimensional geometric model of the porous target bone plate. Then merge the titanium metal parameter package with the .stl file in the Building Processing interface to obtain the .mtt format file that can be recognized by the 3D printer device, and input the .mtt format file into the 3D printing device for printing. The width of the bone plate It is 1.2cm and the length is 10cm; the diameter of the screw is 2.7mm, and the length is 14mm. Then, tantalum metal was deposited on the prepared porous titanium bone ...

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Abstract

The invention provides a personalized 3D printing porous titanium-based tantalum metal-coating bone fracture plate with osteoinductive activity. The plate is prepared by taking titanium metal powder or titanium alloy metal powder as a base material, and forming a tantalum coating on the surface of a porous titanium-based bone fracture plate which is prepared by 3D printing processing and has a void structure. The porous titanium-based tantalum metal-coating bone fracture plate has the porosity of 50-80%, the bending strength of 50-150 MPa, the elastic modulus of 2-30 GPa, the void diameter of200-800 [mu]m and the tantalum coating thickness of 30-60 [mu]m, and has sufficient strength and good osteoinductive performance. The implanted bone fracture plate conforming to the anatomical structure of the fracture part can form excellent bone integration with bone tissues, and the problem that a conventional bone fracture plate easily gets loosened and breaks after being implanted into a bodyfor a long time is avoided, so that permanent biological internal fixation is achieved.

Description

Technical field [0001] The invention relates to a medical internal fixation device, in particular to a personalized 3D printing porous titanium-based tantalum-coated bone plate with osteoinductive activity for medical fixation of long bone fractures of limbs and a preparation method thereof. Background technique [0002] For long bone fractures of the extremities, open reduction and internal fixation are often used in clinical practice. The curvature of the traditional orthopedic surgery bone plate and the screw implantation process are often used to ensure accuracy and avoid damage to important structures such as peripheral nerves, blood vessels, and organs. It is necessary to rely on the experience of the surgeon and the position of the bone plate and the screw multiple times during the operation, resulting in a long operation time, the bone plate and the bone cannot be tightly combined, and the risk of screw loosening and failure. At present, the commonly used bone plate mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/80B33Y10/00A61L31/02A61L31/14
CPCA61B17/80A61B2017/00526A61L31/022A61L31/14A61L31/146B33Y10/00
Inventor 赵德伟马志杰李军雷
Owner 赵德伟
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