Medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and preparation method thereof

A composite rod, osteoinductive technology, applied in pharmaceutical formulations, medical science, manufacturing tools, etc., can solve the problems of rapid degradation of implanted magnesium alloys, loss of osteoinductive activity, poor adhesion, etc., and achieves obvious osteoinductive activity. The effect of obvious biocompatibility and good mechanical properties

Inactive Publication Date: 2020-05-26
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the deficiencies in the prior art, one of the purposes of the present invention is to provide a medical degradable magnesium-zinc-magnesium composite rod with osteoinductive activity, to solve the following technical problems: ① how to solve the problem of excessive degradation of magnesium alloys for medical implants ② How to solve the problem of poor adhesion of the biological coating on the surface of the rod, which is easy to fall off during operation and lose its osteoinductive activity; ③ How to solve the problem that degradable materials have certain anti-inflammatory and antibacterial effects The problem

Method used

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  • Medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and preparation method thereof
  • Medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and preparation method thereof
  • Medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and preparation method thereof

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Experimental program
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Embodiment 1

[0034] Such as Figures 1 to 3 Shown: a medical degradable magnesium-zinc-magnesium composite rod with osteoinductive activity, the innermost layer of the composite rod is deformed magnesium alloy layer 1, the middle layer is zinc alloy layer 2, and the outermost layer is cast magnesium The alloy layer 3, the deformed magnesium alloy layer 1 is provided with dovetail ribs I1-1 and dovetail grooves I1-2 combined with the zinc alloy layer, and the dovetail ribs I1-1 and dovetail grooves I1-2 are formed on the deformed magnesium alloy layer The circumferential direction of 1 is evenly spaced, and the dovetail rib I1-1 is provided with protrusions I1-1-1 and grooves I1-1-2 at intervals along the length direction of the bar, and the dovetail groove I1-2 runs through the length direction of the bar ;

[0035] The zinc alloy layer 2 is provided with dovetail ribs II 2-1 and dovetail grooves II 2-2 combined with the cast magnesium alloy layer 3, and the dovetail ribs II 2-1 and dovet...

Embodiment 2

[0040] A method for preparing a medical degradable magnesium-zinc-magnesium composite rod with osteoinductive activity, comprising the following steps:

[0041] (1) Preparation of magnesium alloy melt

[0042] 1) Alloy ingredients: The chemical composition is calculated by mass percentage: Cu 2.2%, Ag 1.5%, Sr 1.2%, Ca 2.2%, Y 0.5%, La 1.0%, and the balance is Mg.

[0043] 2) Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 －4 Pa, pass in argon gas with a purity of 99.99% for 3 times of repeated gas scrubbing, smelting with electricity, the temperature is 750°C, and the holding time is 60 minutes.

[0044] (2) Preparation of deformed magnesium alloy layer

[0045] The magnesium alloy melt is poured into an ingot, and then the ingot is turned over 180° and remelted 5 times to ensure the uniformity of the composition; then the ingot is homogenized, and the homogenization treat...

Embodiment 3

[0071] A method for preparing a medical degradable magnesium-zinc-magnesium composite rod with osteoinductive activity, comprising the following steps:

[0072] (1) Preparation of magnesium alloy melt

[0073] 1) Alloy ingredients: The chemical composition is calculated by mass percentage: Cu 2.5%, Ag 1.8%, Sr 1.4%, Ca 2.6%, Y 0.9%, La 1.2%, and the balance is Mg.

[0074] 2) Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 －4 Pa, pass in argon gas with a purity of 99.99% for 3 times of repeated gas scrubbing, smelting with electricity, the temperature is 750°C, and the holding time is 60 minutes.

[0075] (2) Preparation of deformed magnesium alloy layer

[0076] The magnesium alloy melt is poured into an ingot, and then the ingot is turned over 180° and remelted 5 times to ensure the uniformity of the composition; then the ingot is homogenized, and the homogenization treat...

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Abstract

The invention discloses a medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity, and a preparation method thereof. The innermost layer is a wrought magnesium alloy layer, the middle layer is a zinc alloy layer, the outer layer is a cast magnesium alloy layer, the zinc alloy layer and the cast magnesium alloy layer are connected in the form of dovetail grooves and dovetail protruding edges, protrusions and grooves are formed in the dovetail protruding edges at intervals in the length direction of the bar, the dovetail grooves are communicated in the length direction of the bar, the separation phenomenon between different layers in the length direction of the bar is avoided, liquid alloy is poured around the bar at the solid state and the high temperature ofthe alloy to enable the bar to be metallurgically bonded, and the bonding strength is high. Round holes are formed in the cast magnesium alloy layer, and biological filling layers are arranged in theround holes and cannot fall off when implanted into a human body. The whole material can be completely degraded and does not need to be taken out through a secondary operation. The invention further provides a preparation method of the medical degradable magnesium-zinc-magnesium composite bar with osteoinductive activity. The preparation method has the characteristics of convenience in operation and easiness in industrial production.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, in particular to a medical degradable magnesium-zinc-magnesium composite rod with osteoinductive activity and a preparation method thereof. Background technique [0002] At present, the implant materials mainly used clinically include stainless steel, titanium and titanium alloy, Co-Cr alloy, etc., but the clinical application of these materials has the following problems: ①The elastic modulus of metal materials is much higher than that of human bone modulus, which has a great "stress shielding" effect on local bone tissue, which may lead to the possibility of degeneration or even atrophy of natural bone function; ② is not degradable in the body, and should be used as temporary implant materials such as vascular stents, bone nails, and bone plates When the spicule is removed, a second operation is required to remove it. In this case, biodegradable absorbing materials in vivo have b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/02A61L31/04A61L31/06A61L31/14A61L31/16C22C18/02B22D19/16C22C23/00C22F1/06C21D9/00C22F1/16
CPCA61L31/022A61L31/028A61L31/042A61L31/06A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/104A61L2300/236A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2300/42A61L2400/12B22D19/16C21D9/0075C22C18/02C22C23/00C22F1/06C22F1/165C08L5/08C08L67/04
Inventor 李宇徐艺铭谷晨熙谢颖颖许建中普亚华
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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