A drug-loaded degradable vascular stent

Abstract

The invention provides a drug-loaded degradable vessel stent. The drug-loaded degradable vessel stent comprises a net-shaped stent body with fully-distributed micro-pores, and a drug loaded in the micro-pores; the drug-loaded degradable vessel stent is obtained by carrying out immersion treatment on the stent body in a drug solution to load the drug in the micro-pores of the stent body, and sterilizing, wherein the mass ratio of the stent body to the drugs is 10 to (1 to 2); the stent body is prepared by mixing silk fibroin, chitosan and a degradable polymer; the degradable polymer is preparedby mixing polyglycolic acid and polyamino acid according to the mass ratio of 1 to (2 to 3); the drug is a drug for treating hemadostenosis. The vessel stent has good biocompatibility and has relatively good mechanical property; the restenosis rate can be reduced, and the proliferation of endothelial progenitor cells and the formation of vessels are facilitated.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug-loaded degradable vascular stent. Background technique [0002] The morbidity and mortality of cardiovascular diseases are quite high, which brings with it the high demand for artificial vascular stents. Vascular stents are based on the balloon expansion of the lumen, and an internal stent is placed in the lesion to achieve a stenotic occlusion of the blood vessel, reduce the elastic retraction and reshaping of the blood vessel, and keep the blood flow in the lumen unobstructed. Vascular stents are generally divided into coronary stents, cerebrovascular stents, renal artery stents, aortic stents, etc. [0003] Vascular stents have the following requirements: no bleeding when connected, certain strength and flexibility, stable physical and chemical properties, appropriate porosity, good biocompatibility, etc. [0004] Vascular stents can be divided into metal tant...

AI Technical Summary

Problems solved by technology

[0005] Patent CN102286685B discloses a SiC / stainless steel composite vascular stent material. Although the surface potential of the metal stent is reduced by the good semiconductor properties of the ceramic whiskers, the metal beam will remain permanently after the metal stent is implanted, which may affect the future treatment of patients.

Patent CN101327343B discloses a compound drug vascular stent, the stent body is provided with holes, and different drugs are fixed inside and outside the holes, thereby increasing the biocompatibility of the stent and preventing restenosis, but its essence is still a metal stent, and there are still metal stents. Problems with the stand itself

[0006] Patent CN102764171B discloses an electrospinning composite vascular stent, which consists of two parts: an annular bottom membrane layer and an electrospinning stent layer. The former ensures mechanical properties, and the latter has a typical three-dimensional space structure, which is conducive to cell adhesion and proliferation. They are all made of degradable polymer materials, but they are not loaded with drugs and cannot achieve therapeutic effects such as reducing the rate of restenosis

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