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Degradable bile duct bracket with stone dissolution function and preparation method thereof

A bile duct stent and functional technology, which is applied in the field of medical devices to achieve good histocompatibility, inhibit the occurrence and treatment of gallstones, and be less prone to inflammatory reactions.

Inactive Publication Date: 2011-04-06
苏州同科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a degradable bile duct stent with stone-dissolving function, which solves many shortcomings of the plastic stent and metal stent used in the current interventional treatment of the bile duct, and strengthens the treatment of gallstones by adding stone-dissolving drugs

Method used

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  • Degradable bile duct bracket with stone dissolution function and preparation method thereof
  • Degradable bile duct bracket with stone dissolution function and preparation method thereof
  • Degradable bile duct bracket with stone dissolution function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 The composition ratio (wt%) of various raw materials of the degradable bile duct stent with stone-dissolving function:

[0027] components

[0028] According to the proportion, polylactic acid (molecular weight: 250,000) and sodium cholate were taken, and then vacuum-dried at 45°C for 24 hours, and nucleating agent and plasticizer were added after drying. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feeding speed of 4.0kg / h The obtained mixed raw material is melted and extruded into a tube by a medical catheter precision extruder, the surface of the catheter bracket is cleaned, and then fumigated and sterilized with ethylene peroxide to obtain a degradable bile duct bracket with a stone-dissolving function.

Embodiment 2

[0029] Example 2 Composition ratios (wt%) of various raw materials of the degradable bile duct stent with stone-dissolving function:

[0030]

[0031] According to the ratio, polylactic acid (molecular weight: 250,000), polycaprolactone (molecular weight: 70,000) and sodium edetate were taken, and then vacuum-dried at 45°C for 24 hours. After drying, nucleating agent and plasticizer. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material; at an extrusion temperature of 170°C, a screw speed of 50 rpm and a feeding speed of 4.0kg / h The obtained mixed raw material is melted and extruded into a tube by a medical catheter precision extruder, the surface of the catheter bracket is cleaned, and then fumigated and sterilized with ethylene peroxide to obtain a degradable bile duct bracket with a stone-dissolving function.

Embodiment 3

[0032] Example 3 Composition ratio (wt%) of various raw materials of degradable bile duct stent with stone-dissolving function:

[0033]

[0034] According to the ratio, take polyglycolic acid (molecular weight: 150,000), polycaprolactone (molecular weight: 70,000), 5g sodium cholate and 5g sodium edetate, then vacuum dry at 45°C for 24 hours, and dry After adding nucleating agent and plasticizer. Mix the raw materials in a mixer at a temperature of 40°C and a speed of 300 rpm to obtain a mixed raw material; at an extrusion temperature of 190°C, a screw speed of 50 rpm and a feeding speed of 4.0kg / h The obtained mixed raw material is melted and extruded into a tube by a medical catheter precision extruder, the surface of the catheter bracket is cleaned, and then fumigated and sterilized with ethylene peroxide to obtain a degradable bile duct bracket with a stone-dissolving function.

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Abstract

The invention relates to the technical field of medical instruments, in particular to a degradable bile duct bracket with stone dissolution function and a preparation method thereof. The degradable bile duct bracket is prepared by the following raw materials in proportion: 60-98% by weight (wt) of degradable polymer, 0.1-2.0 % by weight of nucleating agent, 1-15 % by weight of plasticizer, and the balance of stone dissolution drug, wherein the total weight amounts to 100%. The degradable bile duct bracket is obtained by evenly mixing the degradable polymer, the nucleating agent, the plasticizer and the stone dissolution drug, and then fusing and extruding the mixture through a medical catheter precise extruder; by successfully selecting proper degradable polymer, nucleating agent and plasticizer, the defects of the plastic bracket and metal bracket in the bile duct interventional therapy are overcome; moreover, by adding the stone dissolution drug, the curative effective of gall-stone is improved; therefore, the degradable bile duct bracket has wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a degradable bile duct stent with a stone-dissolving function and a preparation method thereof. Background technique [0002] Biodegradable material is a kind of artificially synthesized organic compound, which can be gradually degraded into low molecular weight compounds or monomers through hydrolysis, enzymolysis and other ways in the living body, and then be excreted from the body or participate in the normal metabolism of the body. Inert and degradable in vivo, it has been widely used in various aspects such as drug release carriers, surgical sutures, surgical operations and tissue repair materials. With the in-depth study of biodegradable polymer materials, homopolymers and random copolymers of aliphatic cyclic esters (CL, LA, GA, EO) are the most widely used absorbable biomedical materials in the world, and have been Approved by the US Federal Health an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14A61L31/16A61L31/02
Inventor 任天斌黄超李建波贾梦虹
Owner 苏州同科生物科技有限公司
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