Dental implant with osteogenesis-anti-inflammation-blood glucose three-dimensional response structure and preparation method thereof

A dental implant and osteogenesis technology, which is applied in the field of dental implants with an osteogenic-anti-inflammatory-blood glucose three-dimensional response structure and the preparation thereof, and can solve the problems such as the inability to meet the clinical needs of dental implant restoration in patients with diabetes mellitus.

Active Publication Date: 2020-03-06
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to obtain the desired biological activity and anti-inflammatory effect at the same time through surf...

Method used

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  • Dental implant with osteogenesis-anti-inflammation-blood glucose three-dimensional response structure and preparation method thereof
  • Dental implant with osteogenesis-anti-inflammation-blood glucose three-dimensional response structure and preparation method thereof
  • Dental implant with osteogenesis-anti-inflammation-blood glucose three-dimensional response structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] In this example, a method for preparing a dental implant with an osteogenic-anti-inflammatory-blood sugar three-dimensional response structure is provided, and the steps are as follows:

[0056] (1) Preparation of dental implants with nanopore structure on the surface

[0057] ① Pretreatment

[0058] The threaded pure titanium implants were sandblasted step by step, ultrasonically cleaned in acetone, ethanol and deionized water for 10-20 minutes, taken out and dried naturally, and then placed in HF-H 2 SO 4 In the mixed acid, when no obvious air bubbles are observed on the surface of the implant, take it out, put it in deionized water immediately to prevent the implant surface from being corroded by residual acid, clean it three times with deionized water ultrasonically, take it out and dry the surface with filter paper Blow dry to complete the pretreatment, store in a petri dish, and seal it for use.

[0059] The HF-H 2 SO 4 The concentration of HF in the mixed ac...

Embodiment 2

[0076] In this example, a method for preparing a dental implant with an osteogenic-anti-inflammatory-blood sugar three-dimensional response structure is provided, and the steps are as follows:

[0077] (1) Preparation of dental implants with nanopore structure on the surface

[0078] ① Pretreatment

[0079] The threaded pure titanium implants were sandblasted step by step, ultrasonically cleaned in acetone, ethanol and deionized water for 10-20 minutes, taken out and dried naturally, and then placed in HF-H 2 SO 4 In the mixed acid, when no obvious air bubbles are observed on the surface of the implant, take it out, put it in deionized water immediately to prevent the implant surface from being corroded by residual acid, clean it three times with deionized water ultrasonically, take it out and dry the surface with filter paper Blow dry to complete the pretreatment, store in a petri dish, and seal it for use.

[0080] The HF-H 2 SO 4 The concentration of HF in the mixed ac...

Embodiment 3

[0094] In this example, a method for preparing a dental implant with an osteogenic-anti-inflammatory-blood sugar three-dimensional response structure is provided, and the steps are as follows:

[0095] (1) Preparation of dental implants with nanopore structure on the surface

[0096] ① Pretreatment

[0097] The threaded pure titanium implants were sandblasted step by step, ultrasonically cleaned in acetone, ethanol and deionized water for 10-20 minutes, taken out and dried naturally, and then placed in HF-H 2 SO 4 In the mixed acid, when no obvious air bubbles are observed on the surface of the implant, take it out, put it in deionized water immediately to prevent the implant surface from being corroded by residual acid, clean it three times with deionized water ultrasonically, take it out and dry the surface with filter paper Blow dry to complete the pretreatment, store in a petri dish, and seal it for use.

[0098] The HF-H 2 SO 4 The concentration of HF in the mixed ac...

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Abstract

The invention provides a dental implant with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure. The dental implant consists of a dental implant and a drug controlled-release system with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure, and the drug controlled-release system is composed of an osteogenesis layer, an anti-inflammation layer and a blood glucose sensing layer. The osteogenesis layer is composed of chitosan hydrogel and nano-hydroxyapatite dispersed in the chitosan hydrogel, the anti-inflammation layer is composed of cross-linked quaternized chitosan hydrogel and anti-inflammation substances and glucose oxidase which are dispersed in the cross-linked quaternized chitosan hydrogel, and the blood glucose sensing layer is a coating composed of glucose oxidase. The surface of the dental implant is provided with a nanopore structure, the nanopore structure of the dental implant is filled with the osteogenesislayer of the drug controlled-release system, the osteogenesis layer coats the dental implant, the anti-inflammation layer coats the osteogenesis layer, and the blood glucose sensing layer coats the anti-inflammation layer. The dental implant can promote osseointegration in a hyperglycemia state, provides a new anti-inflammation treatment technology for patients with diabetes mellitus, and can meetthe clinical requirements of dental implant repair of the patients with diabetes mellitus.

Description

technical field [0001] The invention belongs to the field of dental implants, and relates to a dental implant with an osteogenesis-anti-inflammatory-blood sugar three-dimensional response structure and a preparation method thereof. Background technique [0002] Implant restoration has become a routine repair method for missing or missing dentition. However, for complex cases, such as patients with systemic diseases such as diabetes and osteoporosis, because the current surface modification methods and preparation processes of titanium implants cannot meet the complex clinical requirements, implant restoration is still a relative contraindication, which limits the its clinical application. Therefore, the development of dental implants suitable for patients with systemic diseases has become a new challenge in the field of implant restoration. [0003] Diabetes can easily lead to imbalance of bone metabolism, aggravated local inflammatory response, and severe damage to period...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58
CPCA61L27/32A61L27/34A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58A61L2300/204A61L2300/252A61L2300/254A61L2300/256A61L2300/41A61L2300/414A61L2420/02A61L2420/04A61L2420/06A61L2420/08A61L2430/12C08L5/08
Inventor 王琪王倩张鹏周欣奕赵鹏飞聂鲁凌霄梁星丁一
Owner SICHUAN UNIV
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