54results about How to "Reduce medication burden" patented technology

The invention provides an industrialized production and synthesis process of an adefovir dipivoxil raw medicine. The synthesis process comprises the following process routes of: reacting 2-chlorohydrin subjected to cholromethylation and triisopropyl phosphite to generate an adefovir lateral chain which is condensed and hydrolyzed with adenine to generate adefovir, and then carrying out condensation on the adefovir and chloromethyl pivalate to prepare the adefovir dipivoxil product. The invention has simple process, easy operation, safety, environment protection, mild reaction condition and high product purity, uses the most elementary raw materials and common reagents, and can be used for industrialized production. The invention is used for producing the adefovir dipivoxil raw material.

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

The invention discloses a spirodiclofen-containing compound pesticidal composition. Effective components of the spirodiclofen-containing compound pesticidal composition comprises a component I and a component II, wherein the component I is spirodiclofen; the component II is one of indoxacarb, chlorantraniliprole, tolfenpyrad, chromafenozide, pyridalyl,flubendiamide and chlorfluazuron; and the mass ratio of the component I to the component II is 40:1-1:40. The invention further discloses a preparation which is prepared from the spirodiclofen-containing compound pesticidal composition and is suitable for agricultural use, and application of the spirodiclofen-containing compound pesticidal composition to pest control of crops. The spirodiclofen-containing compound pesticidal composition has a significant synergistic effect and is applied to the pest control of the crops such as fruit trees, cotton, wheat, vegetables, flower, rice and the like, especially with significant effect on control of lepidopteran pests and mite pests.

The invention discloses a composite pesticide composition containing spirodiclofen, the effective components of the composition comprise a component I and a component II, wherein the component I is spirodiclofen, the component II is one component selected from the following components: pymetrozine, thiamethoxam, nitenpyram, clothianidin, dinotefuran, spirotetramat and flonicamid, and the mass ratio of the component I to the component II is 50:1 to 1:50. The invention also discloses a preparation, which is prepared from the composition mentioned above and is suitable for being applied to the agriculture, and an application of the composition mentioned above in the crop pest control. The composite pesticide composition containing spirodiclofen has a prominent synergetic effect, can be used to control pests in fruit trees, cottons, wheat, vegetables, and flowers, and especially has a prominent control effect on pests with piercing-sucking mouthparts and mite pests.

The invention discloses a medicine preparation containing 5-fluorouracil drug eutectic with nicotinamide as a precursor and a preparation method of the medicine preparation.5-fluorouracil raw material medicine is selected as medicine API, nicotinamide serves as the medicine precursor, a liquid-phase assisted grinding method is adopted, the high-purity 5-fluorouracil drug eutectic is obtained, and the effect that the medicine can be more stable can be achieved; in addition, the invention further provides the medicine preparation containing the 5-fluorouracil drug eutectic, the medicine preparation comprises tablets, slow-release tablets, microspheres, micro-capsules, suppository, emulsion, a film agent and an injection agent so that stability and the curative effect of the 5-fluorouracil drug eutectic with the nicotinamide as the precursor can be better improved, different medicine application modes are utilized, and possibility of fully playing the treatment function of medicine and lowering or avoiding adverse reactions is provided.Auxiliaries applied to the preparation method of the preparation are easy to buy in the market and low in price, therefore cost is quite low, and the medicine application burden of patients can be remarkably lowered.

The invention provides a pharmaceutical composition containing sildenafil citrate, which adopts a wet granulation process and comprises the following components in percentage by weight: 3 to 45 percent of sildenafil citrate, 0.5 to 5 percent of adhesive, 2 to 20 percent of sweetening agent, 3 to 20 percent of disintegrating agent, 0.5 to 3 percent of flow aid, 0.5 to 5 percent of lubricating agent, and the balance of filler. The filler is selected from a mixture of microcrystalline cellulose and mannitol; the adhesive is selected from one or a mixture of more than one of povidone, hydroxypropyl methylcellulose and hydroxy propyl cellulose; the disintegrating agent is selected from one or a mixture of more than one of polyvinylpolypyrrolidone, croscarmellose sodium and low-substituted hydroxy propyl cellulose, and the pharmaceutical composition is a low-dose dispersible tablet of sildenafil citrate and has the advantages of low cost, easiness in preparation, high dissolution speed and short disintegration time.

The invention discloses an external traditional Chinese medicine ointment for treating scapulohumeral periarthritis. The external traditional Chinese medicine ointment is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of spreading hedyotis herb, 8-12 parts of cassia twig, 12-15 parts of incised notopterygium, 15-20 parts of white peony root, 18-25 parts of clematis root, 8-12 parts of zedoary rhizome, 8-12 parts of cape jasmine fruit, 3-5 parts of borax, 5-6 parts of rhizoma corydalis, 8-12 parts of weeping forsythia capsule, 10-12 parts of root of lobed kudzuvine, 8-12 parts of mongolian dandelion herb, 8-12 parts of safflower, 10-15 parts of schizonepeta spike, 2-5 parts of oxytetracycline powder, 8-12 parts of fruit-spike of common selfheal, 8-12 parts of barbed skullcap herb, 8-12 parts of Chinese thorowax root, 8-12 parts of milkvetch root, 8-10 parts of dried tangerine peel, 10-12 parts of flower of Japanese pagodatree, 12-15 parts of tree peony bark and 4-6 parts of talc powder. The external traditional Chinese medicine ointment disclosed by the invention is dialectical in compatibility of all raw medicinal materials to achieve the effects of clearing away heat and toxic materials, promoting blood circulation to dispel blood stasis, invigorating spleen and kidney, regulating qi to relieve epigastric distention, diminishing inflammation and relieving pains and the like, has a significant curative effect on scapulohumeral periarthritis patients, is high in cure rate and quick in response, and does not have toxic or side effects.

The invention relates to a traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and a preparing method and application thereof. The traditional Chinese medicine composition is prepared from the roots of red-rooted salvia, radix notoginseng, ginseng, flos rosae rugosae, rhizoma alismatis, ginkgo leaves, hawthorn, rhizoma chuanxiong, lotus leaves, safflowers, gastrodia elata and rhodiola rosea. The traditional Chinese medicine composition has the advantages of being lasting in effect and high in cure rate; the effective-ingredient extraction ratio of the preparing method is high, and capsules prepared with the method are convenient to take.

The invention provides a new application of dracorhodin A, including an application of dracorhodin A in preparation of hypoglycemic drugs, health-care products or functional foods, and further including an application of dracorhodin A in preparation of an alpha-glucosidase activity inhibitor. The application creatively finds that dracorhodin A can inhibit the activity of alpha-glucosidase, and theinhibitory activity of dracorhodin A is far higher than that of acarbose serving as a clinical drug. The invention also provides a hypoglycemic composition, which comprises dracorhodin A and pharmaceutic adjuvants or health-care product adjuvants, and is used as a pharmaceutical preparation or a health-care product preparation.

The invention provides a dental implant with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure. The dental implant consists of a dental implant and a drug controlled-release system with an osteogenesis-anti-inflammation-blood glucose three-dimensional response structure, and the drug controlled-release system is composed of an osteogenesis layer, an anti-inflammation layer and a blood glucose sensing layer. The osteogenesis layer is composed of chitosan hydrogel and nano-hydroxyapatite dispersed in the chitosan hydrogel, the anti-inflammation layer is composed of cross-linked quaternized chitosan hydrogel and anti-inflammation substances and glucose oxidase which are dispersed in the cross-linked quaternized chitosan hydrogel, and the blood glucose sensing layer is a coating composed of glucose oxidase. The surface of the dental implant is provided with a nanopore structure, the nanopore structure of the dental implant is filled with the osteogenesislayer of the drug controlled-release system, the osteogenesis layer coats the dental implant, the anti-inflammation layer coats the osteogenesis layer, and the blood glucose sensing layer coats the anti-inflammation layer. The dental implant can promote osseointegration in a hyperglycemia state, provides a new anti-inflammation treatment technology for patients with diabetes mellitus, and can meetthe clinical requirements of dental implant repair of the patients with diabetes mellitus.

The invention relates to a dexamethasone slow-release microsphere for injection in a glass body. The microsphere contains dexamethasone and poly(lactide-co-glycolide). A solvent volatilizing method isadopted to prepare the microsphere, the preparation conditions are mild, the requirements for equipment are low, industrial production is easy, and a conventional injection needle can be used for completing administration in the glass body. The drug loading ratio of the prepared dexamethasone slow-release microsphere reaches 10-20%, the release behavior of the first-day release rate being less than or equal to 10%, the 7th day cumulative release rate being less than or equal to 30%, the 14th day cumulative release rate being 30% to 80% and the 21st day cumulative release rate being greater than or equal to 55% can be achieved, the effective treatment concentration is maintained for six months, through a stability test, it is shown that the quality characteristic is not changed significantly, the redissolving effect is good, and the microsphere is convenient for clinical application.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating allergic rhinitis. The composition comprises siberian cocklebur herb, and also comprises optional one or more of winkled gianthyssop herb, dahurian angelica roots, biond magnolia flower-bud, forsythia fruits and baical skullcap roots. The traditional Chinese medicine composition for treating rhinitis is easy to absorb, has small side effect in use, can quickly and effectively treat nasal obstruction and rhinorrhea and keep smooth respiration, has quick effect and high cure rate for treating allergic rhinitis, greatly reduces the drug burden of patients, and is suitable for popularization and application.

The invention relates to a cefaclor granule pharmaceutical composition, and belongs to the technical field of pharmaceutical preparations. According to the technical scheme, the cefaclor granule composition contains cefaclor, corn starch, cane sugar, sodium carboxymethyl starch, silicon dioxide and hydroxypropyl methylcellulose, and the dosage of the hydroxypropyl methylcellulose and the dosage ofthe sodium carboxymethyl starch are not lower than 9% of the total weight of a unit dose product respectively. The mass ratio of the hydroxypropyl methylcellulose to the sodium carboxymethyl starch is 1: 1, the mass ratio of the sum of the dosages of the hydroxypropyl methylcellulose and the sodium carboxymethyl starch to the cefaclor (anhydrous) is (18-24): (12-16), and the viscosity of the hydroxypropyl methylcellulose is less than 100mPa.S (at 20 DEG C). The invention provides the cefaclor granule pharmaceutical composition which is stable in quality and biologically equivalent to originalresearch.

The present invention discloses a Gukang tablet and its preparation method. It is made up by using Chinese medicinal materials of psoralea seed, banana stump, dipsacus root, notoginseng and creeping wood sorrel as raw material through a certain preparation process.

The invention discloses a compound pesticide composition containing spirodiclofen. The effective components comprise a component I and a component II, wherein the component I is spirodiclofen; the component II is one of indoxacarb, chlorantraniliprole, tolfenpyrad, chromafenozide, pyridalyl, flubendiamide and chlorfluazuron; and the mass ratio of the component I to the component II is 40:1-1:40. The invention also discloses an agriculturally applicable preparation formulation prepared from the composition and application of the composition in preventing and treating crop pests. The compound pesticide containing spirodiclofen has an obvious synergistic action, is used for preventing and treating pests on fruit trees, cotton, wheat, vegetables, flowers, rice and other crops, and especially has an obvious effect on preventing and treating Lepidoptera pests and acarid pests.