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Method for preparing composite hydrogel of sodium alginate and artemisia desertorum seed gum

A technology of composite hydrogel and sodium alginate, applied in the fields of biological materials and tissue engineering materials, can solve the problems of inability to form a uniform gel and application difficulties of artemisia gum, and achieve enhanced water absorption and mechanical properties, low cost, The effect of expanding the scope of application

Active Publication Date: 2013-05-08
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong water absorption capacity of Artemisia gum, it cannot form a uniform gel in the water system, which brings difficulties to the application of Artemisia gum in the field of hydrogel.

Method used

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  • Method for preparing composite hydrogel of sodium alginate and artemisia desertorum seed gum
  • Method for preparing composite hydrogel of sodium alginate and artemisia desertorum seed gum
  • Method for preparing composite hydrogel of sodium alginate and artemisia desertorum seed gum

Examples

Experimental program
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Effect test

Embodiment 1

[0029] (1) Measure Na at room temperature 2 CO 3 Solution (0.2 mol / L) 100 mL, add 20 mL sodium polystyrene sulfonate (4 g / L), stir well and pour 100 mL CaCl 2 solution (0.2 mol / L), stirred at 1500 rpm for 10 min, and then centrifuged at 4500 rpm to collect the precipitate; the precipitate was washed three times in acetone and distilled water successively; at 0.07 Suction filtration under MPa; collect the filter cake and dry at 60°C for 8 hours to obtain microporous calcium carbonate;

[0030] (2) Weigh 0.03 g of microporous calcium carbonate, add it to sodium alginate solution (the mass ratio of sodium alginate to water is 1:100), and stir evenly to obtain a mixed solution of microporous calcium carbonate-sodium alginate;

[0031] (3) Weigh 0.15g of artemisia gum, add it to 15mL of absolute ethanol, stir evenly, and drop it into the mixed solution of microporous calcium carbonate-sodium alginate at a speed of 1500 rpm at a rate of 10 drops / min , to obtain a mixed s...

Embodiment 2

[0035] (1) Measure Na at room temperature 2 CO 3 Solution (0.3 mol / L) 100 mL, add 20 mL sodium polystyrene sulfonate (3 g / L), stir well and pour 100 mL CaCl 2 solution (0.3 mol / L), stirred at 2000 rpm for 5 min, and then centrifuged at 3500 rpm to collect the precipitate; the precipitate was washed three times in acetone and distilled water successively, at 0.06 Suction filtration under the condition of MPa, the collected filter cake was dried at 60°C for 7 hours to obtain microporous calcium carbonate;

[0036] (2) Weigh 0.04 g of microporous calcium carbonate, add it to sodium alginate solution (the mass ratio of sodium alginate to water is 1:200), and stir evenly to obtain a mixed solution of microporous calcium carbonate-sodium alginate;

[0037] (3) Weigh 0.075g of artemisia gum, add it into 15mL of absolute ethanol and stir evenly, then drop it into the mixed solution of microporous calcium carbonate-sodium alginate at a speed of 15 drops / min at 1500 rpm , to...

Embodiment 3

[0041] (1) Measure Na at room temperature 2 CO 3 Solution (0.3 mol / L) 100 mL, add 20 mL sodium polystyrene sulfonate (2 g / L), stir well and pour 100 mL CaCl 2 solution (0.3 mol / L), stirred at 1800 rpm for 8 min, and then centrifuged at 4000 rpm to collect the precipitate; the precipitate was washed three times in acetone and distilled water successively, and the Under the condition of suction filtration, the collected filter cake was dried at 60°C for 6 hours to obtain microporous calcium carbonate;

[0042] (2) Weigh 0.05 g of microporous calcium carbonate, add it into sodium alginate solution (the mass ratio of sodium alginate to water is 1:50), and stir evenly to obtain a mixed solution of microporous calcium carbonate-sodium alginate;

[0043] (3) Weigh 0.045g of artemisia gum, add it to 15mL of absolute ethanol, stir evenly, and drop it into the mixed solution of microporous calcium carbonate-sodium alginate at a speed of 20 drops / min at 1800 rpm , to obtain a...

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Abstract

The invention discloses a method for preparing a composite hydrogel of sodium alginate and artemisia desertorum seed gum. The method comprises the steps of: introducing the artemisia desertorum seed gum in a sodium alginate solution system, and slowly releasing Ca<2+> in a glucolactone solution by utilizing micropore calcium carbonate, thereby forming the composite hydrogel of sodium alginate and artemisia desertorum seed gum in situ. The properties of the sodium alginate and the artemisia desertorum seed gum are complementary, so that the water absorption capability and the mechanical properties of the sodium alginate base composite hydrogel are enhanced and the application range of the sodium alginate serving as a medicament carrier and a tissue engineering material is expanded. The strength and the gelation time of the the composite hydrogel prepared by the method can be regulated and optimized by changing the proportion of each component and the concentration of glucolactone so as to meet the requirements in different fields. In addition, the method is simple without needing special equipment; the reaction occurs in normal temperature and normal pressure and is simple and controllable; and the method is low in cost and suitable to popularization and application.

Description

technical field [0001] The invention belongs to the field of biological materials and tissue engineering materials, and relates to the preparation of a sodium alginate-based composite hydrogel used for drug carriers or tissue engineering materials, in particular to the preparation of a sodium alginate-artemisia gum composite hydrogel Preparation. technical background [0002] Sodium alginate is a natural linear polysaccharide of brown algae, which is widely used in cosmetics, food and pharmaceutical preparations. It is non-toxic and non-irritating, and can be taken orally and externally. The gel formed by sodium alginate has good bioadhesion, biocompatibility, biodegradability and no toxic and side effects, and is an excellent drug carrier and tissue engineering material. However, during the gel formation process of sodium alginate, Ca 2+ Usually used as a crosslinking agent. direct addition of Ca 2+ The gelation speed is fast, and the resulting gel is extremely uneven...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L5/00C08K7/24C08K3/26C01F11/18
Inventor 王俊龙李先洲赵美珍赵保堂姚健张继
Owner NORTHWEST NORMAL UNIVERSITY
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