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Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method

A technology of calcium carbonate microspheres and calcium alginate, which is applied in the directions of non-active ingredients, such as medical preparations, pharmaceutical formulations, inorganic non-active ingredients, etc., can solve the problems of affecting the use effect, easy to break, and low surface strength of gel beads. , to achieve the effect of good adsorption performance of active substances and improvement of surface strength

Inactive Publication Date: 2007-06-27
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The calcium alginate gel beads prepared by the above methods have a common disadvantage that the surface strength of the gel beads is not high, and they are easy to break, which affects its actual use effect.

Method used

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  • Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The porous calcium carbonate microspheres (see Fig. 1) of 40g 5 μm are uniformly dispersed in the sunflower oil of 4L, then 1L 1% sodium alginate aqueous solution is added dropwise in the mixed solution of porous calcium carbonate microspheres and sunflower oil, at 150rpm Stir for 10 min at a rotating speed of 10 min to form an emulsion. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface (see Figure 2), with regular appearance and high degree of sphericity. The particle size is between 100 μm and 1000 μm.

Embodiment 2

[0030] Evenly disperse 30g of 5 μm porous calcium carbonate microspheres in 4L of sunflower oil, then add 1L of 1% sodium alginate aqueous solution dropwise to the mixed solution of porous calcium carbonate microspheres and liquid paraffin, and stir at 150rpm for 10min. An emulsion is formed. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface. 1000μm.

Embodiment 3

[0032] Evenly disperse 50g of 1 μm porous calcium carbonate microspheres in 4L of sunflower oil, then add 1L of 1% sodium alginate aqueous solution dropwise to the mixture of porous calcium carbonate microspheres and decane, and stir at 150rpm for 10min. An emulsion is formed. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface. 1000μm.

[0033] In the foregoing examples, the coverage of the porous calcium carbonate microspheres on the surface shell of the prepared calcium alginate gel beads is regulated by the weight ratio of the porous calcium carbonate microspheres to the sodium alginate aqueous solution. Gel beads with different surface strengths and penetration rates need to be prepared.

[0034] As can be seen from the above, the present invention can improve the surface strength of the gel beads and im...

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Abstract

The present invention relates to preparation process of calcium alginate gel bead with shell of porous calcium carbonate microsphere. Water phase of sodium alginate is dispersed in oil phase containing porous calcium carbonate microsphere and the mixture is emulsified to form water-in-oil emulsion. The porous calcium carbonate microsphere is adsorbed to the surface of the emulsion drop to form the shell stabilizing the emulsion drop, and water solution of gluconolactone is added for the geltinization reaction of sodium alginate. The present invention makes it possible to match prepare micro bead comprising porous calcium carbonate microsphere as shell and calcium alginate gel as core.

Description

technical field [0001] The invention relates to a controlled-release carrier in the field of biomedicine, in particular to calcium alginate gel beads with porous calcium carbonate microspheres as shell layers and a preparation method thereof. Background technique [0002] Calcium alginate gel beads are currently commonly used cell and protein immobilization materials, especially the microcapsules formed by outer polymer material membranes (such as polylysine and chitosan) are used as immune isolation tools for cell transplantation and protein and protein. The controlled-release carrier of polypeptide biologically active substances has great application prospects in the field of biomedicine. Calcium alginate gel beads are prepared by cross-linking sodium alginate with calcium ions. Among the preparation methods of calcium alginate gel beads reported so far, the electrostatic method (Canadian patent No. 1241598) is to squeeze the sodium alginate solution through the needle an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/02A61K9/00A61K9/16
Inventor 王朝阳刘红霞高权星童真
Owner SOUTH CHINA UNIV OF TECH
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