138results about How to "High proximity" patented technology

The subject invention is a series of methods and systems for using the Surface-Enhanced Raman (SER)-labeled Gene Probe for hybridization, detection and identification of SER-labeled hybridized target oligonucleotide material comprising the steps of immobilizing SER-labeled hybridized target oligonucleotide material on a support means, wherein the SER-labeled hybridized target oligonucleotide material comprise a SER label attached either to a target oligonucleotide of unknown sequence or to a gene probe of known sequence complementary to the target oligonucleotide sequence, the SER label is unique for the target oligonucleotide strands of a particular sequence wherein the SER-labeled oligonucleotide is hybridized to its complementary oligonucleotide strand, then the support means having the SER-labeled hybridized target oligonucleotide material adsorbed thereon is SERS activated with a SERS activating means, then the support means is analyzed.

An information handling system includes a processor having access to a system memory. The system is operable to detect a thermal alert and identify an associated portion of system memory. The system may then modify memory allocation information used by an operating system to allocate system memory. When the thermal alert indicates a rising memory module temperature that exceeds a specified threshold, the modification of the memory allocation information causes the memory to appear to be more “distant” from the system processor(s) and thereby allocated less preferentially than other memory. If the temperature continues to rise beyond a higher threshold, a second modification of the memory allocation information is performed to simulate a “hot eject” of the memory module. As the memory module cools, the memory allocation information can be restored to simulate a hot add of the memory module and to restore the proximity of the memory module.

The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as “the drug uptake capability”). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.

The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as “the drug uptake capability”). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.

The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (NpxN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.

A proximity sensor for use with a guidance system of a smart bomb including a ranging radar proximity sensor configured for mounting on a smart bomb and a radome connected to the ranging radar proximity sensor. A laser radiation sensor system is attached to the proximity sensor, which is configured and arranged to detect laser radiation reflected from a target which passes through the radome and output the azimuth and elevation angles to the target to the guidance system.

A semiconductor package, provided with a multilayer interconnect structure, for mounting a semiconductor chip on its top surface, wherein a topmost stacked structure of the multilayer interconnect structure includes a capacitor structure, the capacitor structure having a dielectric layer comprised of a mixed electrodeposited layer of high dielectric constant inorganic filler and insulating resin and including chip connection pads for directly connecting top electrodes and bottom electrodes with electrodes of the semiconductor chip, whereby greater freedom in design of interconnect patterns can be secured, the degree of proximity of the capacitor and semiconductor chip can be greatly improved, and the package can be made smaller and lighter in weight, a method of production of the same, and a semiconductor device using this semiconductor package.

An inductive proximity sensor and related method for sensing a presence / position of a target, with mounting effect compensation, are disclosed. In at least one embodiment, the method includes providing a proximity sensor having first and second coils that are both at least indirectly in communication with control circuitry. The method also includes receiving respective first and second signals at least indirectly indicative of respective first and second electromagnetic field components respectively experienced by the first coil as influenced both by a target and a structure supporting the sensor and the second coil as influenced by the supporting structure. The method further includes determining by way of the circuitry a third signal based at least in part upon the first signal, as modified based at least in part upon the second signal, whereby the third signal is indicative of the presence or position of the target relative to the sensor.

A FinFet formed by depositing a thin layer of polycrystalline silicon followed by depositing a stress containing material, including a high Ge percentage silicon germanium film and / or a high stress W film on top of a polycrystalline silicon film. Freeing space between fins allows stressor films to be deposited closer to the transistor channel, improving the proximity of the stress containing material to the transistor channel and enhancing the stress coupling efficiency by defining a ratio between stress level in the stressor film and stress transferred to the channel for a mobility enhancement. The stress level is enhanced by patterning by removing the n-type workfunction metal from the p-FinFET. After stripping off the soft or hard mask, the p-type workfunction metal is deposited in the n- and p-FinFET regions. The freed space specifically for p-FinFet between the fins achieves an even higher stressor coupling to further boost the carrier mobility.

A semiconductor package, provided with a multilayer interconnect structure, for mounting a semiconductor chip on its top surface, wherein a topmost stacked structure of the multilayer interconnect structure includes a capacitor structure, the capacitor structure having a dielectric layer comprised of a mixed electrodeposited layer of high dielectric constant inorganic filler and insulating resin and including chip connection pads for directly connecting top electrodes and bottom electrodes with electrodes of the semiconductor chip, whereby greater freedom in design of interconnect patterns can be secured, the degree of proximity of the capacitor and semiconductor chip can be greatly improved, and the package can be made smaller and lighter in weight, a method of production of the same, and a semiconductor device using this semiconductor package.

The inventions describes a method for increasing effector T cell accumulation in cancer cell-containing sites of a tumor, comprising administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of CXCR4 signaling.

The present invention relates to a micro-hotplate device comprising a frame, a membrane, an active area comprising at least one active layer, and a heating structure designed to heat said active layer, said heating structure having concentric tracks and comprising inner tracks (20) and inner spaces (22) and outer tracks (24) and outer spaces (26) as being the one or two tracks and spaces located the furthest away from the center of the heating structure, characterized in that said outer tracks (24) are designed to be located closer to their neighboring tracks and / or are designed to have a width which is lower thanthose of the inner tracks (20), the width and the spacing of said inner tracks (20) being substantially constant.

An apparatus and method for precisely detecting very small distances between a measurement probe and a surface, and more particularly to a proximity sensor using a constant liquid flow and sensing a liquid mass flow rate within a bridge to detect very small distances. Within the apparatus the use of a flow restrictor and / or snubber made of porous material and / or a liquid mass flow rate controller enables detection of very small distances in the nanometer to sub-nanometer range. A further embodiment wherein a measurement channel of a proximity sensor is connected to multiple measurement branches.

An apparatus and method for precisely detecting very small distances between a measurement probe and a surface, and more particularly to a proximity sensor using a constant gas flow and sensing a mass flow rate within a pneumatic bridge to detect very small distances. Within the apparatus the use of a flow restrictor, and / or snubber made of porous material, and / or a mass flow rate controller enables detection of very small distances in the nanometer to sub-nanometer range. A further embodiment wherein a measurement channel of a proximity sensor is connected to multiple measurement branches.

Catalytically activated carbon materials and methods for their preparation are described. The activated carbon materials are engineered to have a controlled porosity distribution that is readily optimized for specific applications using metal-containing nanoparticles as activation catalysts for the mesopores. The activated carbon materials may be used in all manner of devices that contain carbon materials, including but not limited to various electrochemical devices (e.g., capacitors, batteries, fuel cells, and the like), hydrogen storage devices, filtration devices, catalytic substrates, and the like.

The invention relates to a machine tool comprising frame (1) which has rigid side walls (2, 3) with linear guides (4, 5) on the top; compound slides (6, 11) which is movable and situated in or on the linear guides (4, 5) of the side walls, and which guides a processing unit (14) with a spindle head (15) at a front side so as to move the processing unit (14) vertically; and workpiece holding units (24-28) which are arranged in a gap between the side walls and may include a workbench (28) or a workpiece clamping device. One side wall (3) at the front side is shorter than the other side wall (2) for forming an enlarged access to a working space of the machine tool. The linear guides (4, 5) on the side walls (2, 3) of a machine frame (1) are aligned under an acute angle to a vertical center plane of the machine frame (1).

The invention relates to a digital die-free sand mould extrusion forming method, belonging to a combined casting and rapid forming field. The digital die-free sand mould extrusion forming method provided by the invention has the following steps of: establishing a CAD (Computer Aided Design) model according to a sand mould shape, establishing a similar model of a sand mould according to the CAD model, compiling an extrusion head control code, and controlling an extrusion head to generate a similar shape of the sand mould; intruding a shaping material and shaping through extrusion, so as to obtain a sand mould pre-forming piece; and milling the sand mould pre-forming piece so as to obtain a final sand mould. Compared with the conventional shaping method, according to the shaping method provided by the invention, the die manufacturing step is eliminated, the machining process is reduced, the production period is reduced, and the production cost of the sand mould is greatly reduced. The digital die-free sand mould extrusion forming method is particularly applicable to machining and manufacturing a small scale of the sand moulds with complex structures.

An internal combustion engine cylinder head (142) has an exterior wall that contains a walled compartment (140). A wall of that compartment is exposed to an internal coolant passage (146) through which liquid coolant circulates. An exhaust gas passageway (160) running through the compartment has an exhaust gas entrance (162) into the compartment and an exhaust gas exit (164) from the compartment. The compartment comprises a receptacle (148) that intersects the exhaust gas passageway between the entrance and the exit. An EGR valve (10) disposed on the exterior wall comprises a base (12) that has an inlet port (30) and an outlet port (32) and that is disposed within the receptacle with the inlet port open to the entrance via the passageway and the outlet port open to the exit via the passageway. As hot exhaust gas is recirculated, coolant that circulates through the coolant passage aids in limiting peak temperatures to which the valve may be subjected.

The invention discloses a non-contact river surface velocity measurement based regression calculation method for an instantaneous flow rate. According to the method, river multipoint surface flow velocities Vi and a river level height H are measured simultaneously through a non-contact method, a river section area S is obtained according to the river level height H, S is a function of H, that is, S=(S)H, a river surface average flow velocity is obtained according to river multipoint surface flow velocities Vi as following, and then a formula that M=K*Vs*S is used for calculating a river section instantaneous flow rate, wherein Vs is the river surface average flow velocity, and S is the river section area obtained according to the river level height. By the aid of the method, the instantaneous flow rate of a river can be calculated through surface flow velocities, river levels and section data provided by a non-contact velocity measurement technology, the proximity of the data obtained through non-contact measurements to data obtained through manual measurements is high, the error is small, and non-contact measurements can completely substitute for manual measurements.

The present invention is directed to an apparatus for reducing the impact of cross winds on gas flow emitted from a nozzle. The apparatus includes a shroud that affixes to the nozzle. A plenum is located inside the shroud that holds a shroud gas, which is fed into the plenum through one or more intake holes. The shroud gas is emitted out through a series of openings, such as holes or slots, along a bottom surface of the shroud in a direction away from the nozzle. The shroud gas that is emitted forms an air curtain around the nozzle to prevent cross winds from impacting the flow of gas out of the nozzle. In one application, the apparatus is used with a lithography gas gauge proximity sensor. The apparatus can also be used with nozzles that emit liquids, such as, for example, an immersion lithography proximity sensor.

Alicyclic methacrylate compounds having an oxygen substituent group on their α-methyl group, represented by formula (1), are novel wherein R1 is H or C1–C10 alkyl which may contain a halogen atom, hydroxyl group, ether bond, carbonyl group, carboxyl group or cyano group, and R2 is a monovalent C3–C20 organic group having an alicyclic structure. Polymers prepared from these alicyclic methacrylate compounds have improved transparency, especially at the exposure wavelength of an excimer laser, and improved dry etching resistance. Resist compositions comprising the polymers are sensitive to high-energy radiation, show a high resolution, allow smooth development, lend themselves to micropatterning, and are thus suitable as micropatterning material for VLSI fabrication

A public transportation system combines a unique combination of components that includes interoperable electric-powered vehicles, facilities, hardware and software having specifications, standards, processes, capabilities, nomenclature, and concepts of operations that together include a concerted, comprehensive, multi-modal, future system for moving people and goods that is herein named Quiet Urban Air Delivery (QUAD) and in which uniquely-capable, ultra-quiet, one to six-seat, electrically-powered, autonomous aircraft (SkyQarts) fly sub-193 kilometer trips on precise trajectories with negligible control latency and perform extremely short take-offs and landings (ESTOL) with curved traffic patterns at a highly-distributed network of very small, airports (“SkyNests”) that themselves have standardized compatible facilities that interoperate with SkyQarts as well as with versatile, autonomous electric-powered payload carts (EPCs) and robotic delivery carts (RDCs) to provide safe, fast, on-demand, community-acceptable, environmentally friendly, high-capacity, affordable door-to-door delivery of both passengers and cargo across urban, suburban and rural settings across the globe.

An information handling system includes a processor having access to a system memory. The system is operable to detect a thermal alert and identify an associated portion of system memory. The system may then modify memory allocation information used by an operating system to allocate system memory. When the thermal alert indicates a rising memory module temperature that exceeds a specified threshold, the modification of the memory allocation information causes the memory to appear to be more “distant” from the system processor(s) and thereby allocated less preferentially than other memory. If the temperature continues to rise beyond a higher threshold, a second modification of the memory allocation information is performed to simulate a “hot eject” of the memory module. As the memory module cools, the memory allocation information can be restored to simulate a hot add of the memory module and to restore the proximity of the memory module.

The invention provides a method and a system for downloading files by adopting a P2P technology and a client-side. The method specifically comprises the steps: the client-side sends a server query request carried with file resource information to a P2P system; the client-side receives a P2P server IP list returned by the P2P system; the client-side selects one P2P server connected with the network best from the P2P server IP list according to an IP list address field the client-side belongs to, and obtaining seed information of file resources according to the selected P2P server; the client-side shares the file resources according to the seed information of the file resources. The method and the system for downloading the files by adopting the P2P technology can improve the sharing efficiency of the file resources and P2P downloading efficiency.

The present invention relates to a data storage device comprising: a data storage medium for storing data in the form of topographic features; and at least one probe for writing and / or reading the data stored in the data storage medium, wherein the data storage medium is formed on a support layer, the support layer having a lower shear modulus than the data storage medium

Effective proximity service discovery resource reporting and allocation. Embodiments of the invention relate to a method for enhancing proximity service (ProSe) device to device discovery resource allocation, the method comprising: allocating, by a network processing device, network resources to a plurality of user devices including at least one user device in a connected mode and at least one user device in an idle mode, the allocating comprising: restricting network resources allocated to the user device in the idle mode for proximity service discovery compared to the network resources allocated to the user device in the connected mode for proximity service discovery, such that the network resources maintain reliable discovery services for the user device in the connected mode as well as provide acceptable discovery services for the user device in the idle mode.

A control method for a heat pump system, or for a motor vehicle, which includes a compressor, an internal heat exchanger forming a condenser in a heating mode, an expansion valve, an outer heat exchanger forming an evaporator in the heating mode, and an accumulator. The defrosting of the outer exchanger is detected, the defrosting of the accumulator is detected, and depending on the case, defrosting the outer exchanger and / or defrosting the accumulator is started.

A method for producing an absorbent article includes: while conveying non-woven fabric to be a top sheet by drawing from the downstream side, forming extruded projections by embossing; placing a material for a second sheet on the back surface of the non-woven fabric with the extruded projections; and joining the non-woven fabric and material for the second sheet in a joint pattern in which top-second joint portions are formed between the MD direction adjacent extruded projections at CD direction central positions corresponding to CD direction central portions of the adjacent extruded projections and at lateral positions on the CD direction both sides of the central positions. A MD direction joint range of the top-second joint portions is wider continuously or stepwise with increasing proximity from the central position to the lateral sides. This allows joining a top sheet having extruded projections and a second sheet while preventing occurrence of MD direction wrinkles in the top sheet.

The invention relates to a digital die-free sand mold extrusion forming machine, which comprises a forming machine bracket, an extrusion forming workbench and a pressing plate, wherein the pressing plate is controlled by a motor; the pressing plate is connected below the motor and can be lifted; the motor is fixed on the forming machine bracket; the extrusion forming workbench comprises an auxiliary box, a sand box and an extrusion platform; the extrusion platform comprises an extrusion array and transmission equipment; the bottom end of the extrusion array is arranged in the transmission equipment; and the complete sand box consists of the extrusion platform serving as a box bottom. The digital die-free sand mold extrusion forming machine is provided with the adaptive extrusion platform; a prepared sand mold is high in similarity; the time and the cost of subsequent cutting machining are saved; particularly for preparation of a small batch of single sand molds, the manufacturing and machining cost of the sand mold is saved; and the cost for shaping the small batch of single sand molds can be greatly reduced.