The invention discloses an intelligent unattended operation autoweighing system and method for put-out and put-in of a warehouse and relates to the field of industrial metrology, automatic control and the Internet of Things. The system comprises an intelligent starting module, a vehicle running management module, a vehicle guide indication module, an anti-cheating module, a vehicle license plate recognition module, an RFID radio frequency card recognition module, an IC card reading module, a video monitoring ant-cheating module, an information display module, a voice interaction module, an intelligent lighting module, an instrument module and a control host. Through the RFID technology and the automatic detection and analysis technology, automatic recognition of vehicle numbers, weighing information verification, precise positioning of vehicles, personnel and vehicle cheating supervision, snapshot picture analysis, precise value reading of instruments and the like are achieved in the motor truck scale weighing process, unattended operation autoweighing of a motor truck scale is achieved with the advanced weighing method and the advanced control process, manual participation is reduced, and accuracy, reliability and efficiency of the motor truck scale weighing are improved.