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Infant Formula

a technology for infant formula and nutritional composition, which is applied in the direction of peptide/protein ingredients, immunological disorders, metabolism disorders, etc., can solve the problem that not all infants are in the position to receive human milk, and achieve the effect of enhancing the bioactive effect of the nucleotide component in nutritional formulations

Inactive Publication Date: 2008-05-29
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0003]The present inventors have recognized that the molecular structure and density of charge of nucleotides is an important factor for the bioactivity of nucleotide components, particularly nucleotides. It was found that by combining nucleotide components with negatively charged non-protein components the bioactive effects of the nucleotide component in nutritional formulations may be enhanced significantly.
[0006]Enhancing immune cell proliferation, improving the development of T-lymphocyte sub populations, and enhancing the antibody response;
[0013]The present nutritional composition can be even further improved by combining the nucleotide component and NCC with bivalent cations, preferably calcium and / or zinc. The cation will increase proximity of the nucleotide component and the NCC in a liquid environment (e.g. the intestinal tract) by formation of hydrogen / salt bridges, thereby further increasing the interactive effects between the NCC and the nucleotide components.

Problems solved by technology

However, not all infants are in the position to receive human milk.

Method used

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  • Infant Formula
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Examples

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Effect test

example 1

Infant nutrition

[0058]A liquid infant nutrition, prepared by admixing 13.9 g powder with water to yield 100 ml final product, said liquid product comprising per 100 ml:

Energy:66 kcalProtein:8 en %1.3 g (containing 0.6 g casein; 0.8 g whey;0.072 g L-arginine)Digestible44 en %carbohydrates:7.4 g (containing 7.3 g lactose)Fat:48 en %3.5 g (containing 0.41 g linoleic acid;0.08 g α-linolenic acid; 0.012 garachidonic acid; 0.002 g eicosapentanoicacid; 0.006 g docosahexaenoic acid;1.4 g oleic acid;)Fibre:0.8 g (containing 0.05 g fructopolysaccharide(Raftiline HP ™, Orafti, Tienen, Belgium);0.55 g transgalactooligosaccharides(Vivinal-GOS ™ (Borculo Domo Ingredients,Netherlands); 0.20 g pectin hydrolysateprepared as described in EP1373543, example 1.Nucleotide components:0.89 mgCytidine-5-monophosphate;0.55 mgUridine-5-monophosphate;0.82 mgAdenosine-5-monophosphate;0.20 mgGuanosine-5-monophosphate;0.34 mgInosine-5monophosphate.NCC:5 mg GM3, 50 mg pectin derivedoligosaccharides with DP betwee...

example 2

[0060]Composition according to example 1, wherein the nucleotide component is replaced by dinucleosidpolyphosphates (NpxN) Gp4G

example 3

[0061]Composition according to example 1, wherein the nucleotide component is an DNA / RNA oligomers extract

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Abstract

The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (NpxN); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a nutritional composition for feeding infants, containing fat, protein, carbohydrate, a nucleotide component and to the use thereof.BACKGROUND OF THE INVENTION[0002]Breastfeeding optimally supports the development of the infant and protects against infections and allergies. However, not all infants are in the position to receive human milk. It is therefore a continuing aim to provide infant formula, which simulates the functions of human milk. In addition to the desired compositional similarity between infant formula and human milk, it is also particularly desirable to mimic the protective effects of human milk, in particular protection against allergies and infections.SUMMARY OF THE INVENTION[0003]The present inventors have recognized that the molecular structure and density of charge of nucleotides is an important factor for the bioactivity of nucleotide components, particularly nucleotides. It was found that by combinin...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61P37/08A61P1/12A61P17/00A61P29/00A23L33/00
CPCA23L1/296A23L1/3008A61K31/715A61K31/7052A61K31/702A61K31/201A23V2002/00A23L1/3081A23L1/3056A23V2250/28A23V2250/5046A23V2250/1872A23V2250/1874A23V2250/187A23V2250/1868A23V2250/1862A23V2250/5072A23L33/40A23L33/12A23L33/19A23L33/22A61P1/00A61P1/12A61P17/00A61P17/02A61P29/00A61P3/02A61P31/04A61P37/02A61P37/04A61P37/08A61P43/00
Inventor BEERMANN, CHRISTOPHERBOEHM, GUNTHERSTAHL, BERND
Owner NUTRICIA
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