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Method fro determining content of volatile carbonyl compound in main stream smoke of cigarette

A technology for cigarette mainstream smoke and carbonyl compounds, which is applied in the fields of tobacco and chemistry, can solve the problems of difficulty in separation and influence on the accuracy of measurement, and achieve the effect of improving accuracy and optimizing chromatographic analysis conditions

Inactive Publication Date: 2010-05-05
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Crotonaldehyde is the component with the lowest content in the main volatile carbonyl compounds of cigarette mainstream smoke, and through spectral and mass spectrometric analysis, the structure and properties of the interfering component and crotonaldehyde are relatively similar, and it is very difficult to completely separate them on chromatography. thus affecting the accuracy of the determination

Method used

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  • Method fro determining content of volatile carbonyl compound in main stream smoke of cigarette
  • Method fro determining content of volatile carbonyl compound in main stream smoke of cigarette
  • Method fro determining content of volatile carbonyl compound in main stream smoke of cigarette

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Experimental program
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Embodiment

[0080] Using the assay method further described in the specific embodiment, the cigarette samples A, B, and C are detected, and the difference between the chromatographic conditions adopted and the further description is shown in Table 3:

[0081] The difference chromatographic condition of table 3 embodiment

[0082] sample

Injection volume

flow rate

temperature

Detection wavelength

DNPH concentration

(g / ml)

Perchlorate

plot percentage

solution of pyridine

volume percentage

A

10 μL

0.5ml / min

20℃

365nm

0.01

0.3％

1％

B

50μL

1ml / min

40℃

365nm

0.05

0.1％

3％

C

20 μL

1.5ml / min

60℃

380nm

0.03

0.5％

5％

[0083] Other chromatographic conditions such as mobile phase and gradient elution are the same as those further described in the present invention. The detected chromatograms are as follows Fig...

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Abstract

The invention discloses a method for determining content of volatile carbonyl compound in main stream smoke of cigarette. 2, 4-dinitrophenylhydrazine is utilized to gather volatile carbonyl compound in main stream smoke of cigarette, so as to form hydrazone compound, and the content of the hydrazone compound is determined by a high performance liquid chromatograph by adopting external standard method; and the high performance liquid chromatograph adopts chromatographic column. The determination method of the invention adopts chromatographic column, has excellent separating effect on nitro substituted arene derivative, especially on hydrazone compound formed after reaction of 2, 4-dinitrophenylhydrazine and volatile carbonyl compound, and meanwhile chromatographic analysis condition is optimized, thus achieving complete separation of volatile carbonyl compound and interfering component in main stream smoke of cigarette and improving accuracy of determination.

Description

technical field [0001] The invention relates to a method for measuring the content of volatile carbonyl compounds in mainstream smoke of cigarettes, and belongs to the technical field of tobacco and chemistry. Background technique [0002] Volatile carbonyl compounds are one of the main components in cigarette smoke. Among them, lower aldehydes have a strong pungent smell. With the increase of molecular weight, the pungent smell decreases and gradually produces fragrance. Relevant reports (Wyder E.L., Hoffman, Tobacco and Tobacco smoke (1967), Academic Press, New York, p417-418 and Collins.P.F., Tob.Sci. (1970), 14: p182) show that low-level volatile carbonyl groups in cigarettes Compounds such as formaldehyde, acetaldehyde and acrolein are toxic to cilia, and will stimulate the respiratory system and sensory organs of the human body to varying degrees during cigarette smoking, and long-term inhalation will cause serious harm to the human body. With the increasing attention...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 王昇夏巧玲谢复炜刘惠民颜权平刘克建张晓纲
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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