1-aryl-5-pyrazolones, pharmaceutical compositions and uses thereof
By designing 1-aryl-5-pyrazolone compounds and combining COX-2 selective inhibition and free radical scavenging functions, the cardiovascular and gastrointestinal side effects caused by existing NSAIDs have been resolved, achieving effective treatment for chronic inflammatory diseases.
CN120058611BActive Publication Date: 2026-06-02CHINA PHARM UNIV
Patent Information
- Application Number
- CN202311600384.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-28
- Publication Date
- 2026-06-02
- Estimated Expiration
- 2043-11-28
Smart Images
Figure CN120058611B_ABST
Abstract
The application discloses a 1-aryl-5-pyrazolone compound and a pharmaceutical composition and application thereof. The compound has a structure selected from any one of the following structures, and also comprises a tautomer, a pharmaceutically acceptable salt or a mixture thereof: the compound can effectively inhibit COX-2 and effectively scavenge free radicals at a micromolar concentration level, can reduce cardiovascular and digestive tract side effects caused by NSAID-induced free radical production, and can also play a better treatment effect on chronic inflammatory diseases with pain through the synergistic effect of antioxidation stress and anti-inflammatory analgesia.
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Citation Information
Patent Citations
Method for synthesizing adjacent tertiary carbon-quaternary carbon chiral center-containing pyrazole ketone compounds represented by formula (3)
CN109896999A