The invention discloses a preparation method of a 
pentaerythritol tetraacrylate mixture and belongs to the field of 
chemical engineering. The preparation method comprises following processes: (1) feeding reaction materials into a reactor and mixing the reaction materials uniformly; (2) heating the 
reaction system to perform constant-temperature 
reflux to obtain reaction products; (3) cooling the reaction products and washing the reaction products, allowing the reaction products to stand for being layered and obtaining an upper-layer organic phase; (4) adding a 
reducing agent to the organic phase for decoloration; (5) adding a 
polymerization inhibitor and removing solvents in the organic phase in a manner of reduced pressure 
distillation and molecular 
distillation; and (6) adding a 
diluent with mixing and performing pressurized 
filtration to obtain a finish product. The preparation method is free of generation of harmful gases, thereby avoiding 
air pollution. By means of the washing process, residual 
acrylic acid and other impurities in the 
reaction system are removed. By means of the reduced pressure 
distillation for separating the solvents and the 
reaction system and the molecular distillation for removing residual 
solid impurities, the pure finish product is obtained. By means of usage of an anti-
oxidizing agent, feeding of a protective gas and the decoloration, yield of the finish product is increased and chroma of the finish product is reduced. By means of addition of the 
diluent, the finished product is enhanced in stability, is improved in application performances and is wider in application range.