A polylactic acid-trimethylene carbonate film doped with polyglycolic acid particles and its preparation method and application

Abstract

The invention discloses a polylactic acid-trimethylene carbonate film doped with polyglycolic acid particles. In parts by weight, it consists of 1-3 parts of polyglycolic acid particles and 5-5 parts of polylactic acid-trimethylene carbonate copolymer. 15 parts form a film with a thickness of 20-200 μm; the average particle diameter of the polyglycolic acid particles is 10-200 μm, and the molecular weight is 9-110,000; the molecular weight of the polylactic acid-trimethylene carbonate copolymer is 10-200 μm. 200,000; the polylactic acid-trimethylene carbonate film doped with polyglycolic acid particles of the present invention is a non-porous dense film in the early stage of implantation, which can isolate postoperative tissues and has good biocompatibility. Polyglycolic acid degrades faster than polylactic acid-trimethylene carbonate, so micropores can be obtained with the degradation of polyglycolic acid after implantation in the human body. On the one hand, the appearance of micropores accelerates the fragmentation and degradation of materials. On the one hand, the film after micropores can still maintain the original shape, which ensures the effective isolation of the film, shortens the retention time of the film in the human body, and reduces the risk of complications.

Description

technical field [0001] The invention relates to the technical field of sealants, in particular to a polylactic acid-trimethylene carbonate film doped with polyglycolic acid particles and its preparation method and application. Background technique [0002] At present, the polymer materials used to prevent postoperative tissue adhesion in surgical operations generally need to have excellent biocompatibility and biodegradability, such as polylactic acid, polyglycolic acid, polydioxanone, polyhexanone, etc. Lactone, polytrimethylene carbonate, etc., especially polycaprolactone, have good biocompatibility in the body, cells can also grow normally on its skeleton, and can be degraded into carbon dioxide and water, leaving no residue in the body. And it can be molded at low temperature, but the degradation rate of the single polycaprolactone material is slow, and it takes more than 12 to 24 months in the body to degrade completely. The initial strength is high and the mechanical s...

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Problems solved by technology

[0002] At present, the polymer materials used for the films used to prevent postoperative tissue adhesion in surgical operations generally need to have excellent biocompatibility and biodegradability, such as polylactic acid, polyglycolic acid, polydioxanone, polyhexanone, etc. Lactone, polytrimethylene carbonate, etc., especially polycaprolactone, have good biocompatibility in the body, cells can grow normally on its skeleton, and can be degraded into carbon dioxide and water, leaving no residue in the body. And it can be molded at low temperature, but the degradation rate of the single polycaprolactone material is slow, and it takes more than 12 to 24 months in the body to degrade completely. The initial strength is high and the mechanical strength lasts for a long time. Although it can ensure the effective isolation of adhesion tissues, but Breaks down too slowly, risking complications after surgery

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