Dendritic polymer-modified magnetic microspheres with uniform particle sizes and preparation method and application thereof

A technology of magnetic microspheres and polymers, applied in the field of functional materials, can solve the problems of uneven particle size, time-consuming, and many steps, and achieve good dispersion and stability, great application prospects, and uniform particle size.

Active Publication Date: 2018-05-18
JIANGSU ACAD OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation method of dendrimer-modified magnetic microspheres has been reported [CN101955231B, CN103157447B], but the post-modification method is usually adopted, which has many steps and takes a long time
[0004] CN102092795A reports a method for preparing organic polymer modified iron ferric oxide multistage balls, but due to its uneven particle size, its performance will be affected in specific applications, such as poor reproducibility, etc.

Method used

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  • Dendritic polymer-modified magnetic microspheres with uniform particle sizes and preparation method and application thereof
  • Dendritic polymer-modified magnetic microspheres with uniform particle sizes and preparation method and application thereof
  • Dendritic polymer-modified magnetic microspheres with uniform particle sizes and preparation method and application thereof

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preparation example Construction

[0035] The present invention also provides a preparation method of dendritic polymer modified magnetic microspheres with uniform particle size, the method comprising the following steps: S100, preparing a solution for synthesizing magnetic microspheres; S200, uniformly dispersing the dendritic polymer In the solution for synthesizing magnetic microspheres; S300, synthesizing the mixed solution obtained in step S200 into dendrimer-modified magnetic microspheres by a one-pot hydrothermal synthesis method. Such as figure 1 The transmission electron micrograph of the magnetic ferric oxide microspheres modified by the fourth generation of PAMAM dendrimers; as image 3 The fourth generation of PAMAM dendrimer modified magnetic iron ferric oxide microspheres modified boric acid to the extraction amount of adenosine ( image 3 Middle 3), and background literature Chem.Eur.J.2006,12,6341. The extraction amount of adenosine ( image 3 Middle 1), background literature CN103157447B post...

Embodiment 1

[0043] Embodiment 1: Obtained ferroferric oxide magnetic microspheres according to the following preparation method:

[0044] 1.0 parts by weight of ferric chloride hexahydrate, 2.0 parts by weight of anhydrous sodium acetate, and 1 part by weight of the fourth-generation PAMAM dendrimers are successively dissolved in 35.0 parts by weight of ethylene glycol solution, mixed uniformly, and transferred to hydrothermal Reactor, the hydrothermal reaction temperature is 200°C. The reaction time was 6 hours. The prepared magnetic microspheres are washed 3-5 times with methanol, 3-5 times with ethanol, 3-5 times with water and 3-5 times with ethanol. Vacuum dry at 50°C for 12 hours for later use.

[0045] Such as figure 1 as shown, figure 1 It is a transmission electron micrograph of the fourth-generation PAMAM dendrimer-modified magnetic ferric oxide microspheres. It can be seen from the figure that its particle size is uniform, about 100nm.

[0046] figure 2 Infrared image of m...

Embodiment 2

[0047] Embodiment 2: Preparation of cobalt oxide magnetic microspheres:

[0048] 2.0 parts by weight of cobalt chloride hexahydrate, 10 parts by weight of anhydrous sodium acetate, and 2 parts by weight of dendrimers are successively dissolved in 45 parts by weight of ethylene glycol solution, mixed uniformly, transferred to a hydrothermal reaction kettle, and hydrothermally The reaction temperature is 300°C. The reaction time was 8 hours. The prepared magnetic microspheres are washed 3-5 times with methanol, 3-5 times with ethanol, 3-5 times with water and 3-5 times with ethanol. Vacuum dry at 50°C for 12 hours for later use.

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Abstract

The invention relates to dendritic polymer-modified magnetic microspheres with uniform particle sizes and a preparation method and application thereof. Through use of a dendritic polymer on the surface of a magnetic carrier, the magnetic microsphere is obtained. The magnetic carrier is a magnetic nanoparticle or a magnetic microparticle. The preparation method comprises directly dispersing the dendritic polymers in a solution for synthesis magnetic microspheres and directly synthesizing the dendritic polymer-modified magnetic microspheres through a hydrothermal synthesis one-pot method. The magnetic microspheres have the better capability of enrichment, have uniform magnetic particle sizes, are prepared through simple processes and are free of post-modification.

Description

technical field [0001] The invention relates to the field of functionalized materials, in particular to a dendrimer-modified magnetic microsphere with uniform particle size and a preparation method and application thereof. Background technique [0002] Magnetic microspheres include magnetic nanoparticles and microparticles. Due to their special physical and chemical properties, they have broad application prospects in the fields of materials and biology, such as magnetic separation and magnetically targeted delivery of drugs. In order to adapt to different purposes, a variety of modified magnetic microspheres and their composite structures, such as functionalized silicon-coated magnetic microspheres, polymer grafted magnetic microspheres and other materials have been widely prepared. And get practical application. Generally, the prepared functionalized magnetic microspheres have a low surface group content and need to be detected and characterized by highly sensitive detect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/06
CPCB01J13/06
Inventor 王合叶王冉
Owner JIANGSU ACAD OF AGRI SCI
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