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Catalytic synthesis of 1,3-diphenyl acetone

A technology of diphenylacetone and synthesis method, applied in 1, can solve problems such as non-continuous process, serious pollution, expensive and difficult to obtain raw materials, etc., and achieve the effect of high conversion rate

Inactive Publication Date: 2005-10-12
FUDAN UNIV
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Problems solved by technology

Its synthesis is mainly through the oxidation of the corresponding alcohol in the presence of pyridinium chromate chloride and aluminum oxide, or the reaction of the corresponding oxime with cobalt octacarbonyl in the presence of triethylamine. The raw materials are expensive and difficult to obtain, and the process is complicated. , the pollution is serious and cannot be carried out continuously

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  • Catalytic synthesis of 1,3-diphenyl acetone

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Embodiment

[0019] 1. 600 mg of manganese-aluminum catalysts prepared by the attached precipitation method are packed into a stainless steel reactor with a diameter of 8 mm. The content of manganese oxide particles in the catalyst is 10%, and the content of gamma-alumina is 90%. Catalyst is prepared as follows:

[0020] (1) Manganese oxide is supported on γ-alumina by the attachment precipitation method. Mix 4.000 grams of γ-alumina with 2.601 grams of 50% manganese nitrate aqueous solution, add ammonia water dropwise under full stirring until the precipitation is complete, continue to stir for half an hour and then let it stand for 5-20 hours. After the suspension is filtered by suction, the solid particles are used up. Ionized water washing;

[0021] (2) Add an appropriate amount of oxides to add components to the surface of the manganese-aluminum catalyst by impregnation;

[0022] (3) Dry the above solid at 80-150°C, bake it in the air atmosphere at 400-700°C for 2-5 hours, and then ...

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Abstract

A catalytic synthesis of 1,3-diphenyl acetone by methyl phenylacetate gas-phase hydrogenation is carried out by taking composite manganese-aluminum as catalyst, loading manganese oxide on gamma -Al2O3, directly catalyzing methyl phenylacetate by catalyst, synthesizing 1,3-diphenyl acetone, or modifying one or several elements of Zr, Zn or Cr. The reacting temperature is 300-500deg.C, the mol ratio of hydrogen ester is 10-100, LHSV=1.0-8.0hr-1. The single-pass percent conversion of methyl phenylacetate reaches to 98.4%, and the selectivity of 1,3-diphenyl acetone reaches to 66.7%.

Description

technical field [0001] The invention relates to a method for synthesizing 1,3-diphenylacetone by gas-phase catalytic hydrogenation of methyl phenylacetate. Background technique [0002] 1,3-Diphenylacetone is widely used as a widely used pharmaceutical intermediate, and is also widely used as fungicide. Its synthesis is mainly through the oxidation of the corresponding alcohol in the presence of pyridinium chromate chloride and alumina, or the reaction of the corresponding oxime with cobalt octacarbonyl in the presence of triethylamine. The raw materials are expensive and difficult to obtain, and the process is complicated. , the pollution is serious and cannot be carried out continuously. Contents of the invention [0003] The object of the present invention is to provide a method for synthesizing 1,3-diphenylacetone with continuous catalytic hydrogenation, simple process, environmental friendliness, high conversion rate and selectivity. [0004] The catalytic hydrogena...

Claims

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Application Information

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IPC IPC(8): C07C45/41C07C49/213
Inventor 徐华龙黄静静沈伟
Owner FUDAN UNIV
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