A method for synthesizing 2,4,5-trifluorophenylacetic acid

The synthesis of 2,4,5-trifluorophenylacetic acid via chloromethylation of 1,2,4-trifluorobenzene and electrochemical methods solves the problems of harsh reaction conditions and poor safety in existing technologies, and realizes efficient and environmentally friendly industrial production.

CN122404128APending Publication Date: 2026-07-17HUNAN YOUSE CHENZHOU FLUORIDE CHEM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN YOUSE CHENZHOU FLUORIDE CHEM CO LTD
Filing Date
2026-04-22
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for synthesizing 2,4,5-trifluorophenylacetic acid suffer from problems such as harsh reaction conditions, expensive or highly toxic catalysts, severe pollution, poor safety, and unsuitability for industrial production.

Method used

Using 1,2,4-trifluorobenzene as a raw material, 2,4,5-trifluorobenzyl chloride is generated through a chloromethylation reaction. Then, 2,4,5-trifluorophenylacetic acid is synthesized by electrolysis with carbon dioxide. This avoids highly toxic cyanide and expensive catalysts, and uses electrodes and electrolytes for electrochemical conversion.

Benefits of technology

It achieves a green and safe synthesis route, reduces production costs, simplifies post-processing, is suitable for industrial production, has high yield, and good safety.

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Abstract

The application discloses a synthesis method of 2,4,5-trifluorophenylacetic acid, which comprises the following steps: S1, 1,2,4-trifluorobenzene is subjected to a chloromethylation reaction to obtain 2,4,5-trifluorobenzyl chloride; and S2, 2,4,5-trifluorobenzyl chloride is subjected to an electrolysis reaction with carbon dioxide to synthesize 2,4,5-trifluorophenylacetic acid. The method optimizes the synthesis process of 2,4,5-trifluorophenylacetic acid, has a short synthesis route, low cost, mild conditions, green safety, simple post-treatment and purification process, and is very suitable for industrialized scale production.
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Citation Information

Patent Citations

  • Method for preparing 2,4,5 trifluorobenzene acetic acid

    CN101092345A

  • Novel method for producing 2,4,5-trifluoro benzene acetic acid

    CN101244994A

  • Process for preparing 2,4,5-triflorophenylacetic acid

    CN1749232A

  • Process for the synthesis of trifluorophenylacetic acids

    US20040077901A1

  • Process for the preparation of fluorophenylacetic acids and derivatives thereof

    WO2008078350A2