Prepn process of beta-hydroxyl-beta-methyl butyric calcium (HMB-Ca)

A technology of calcium methylbutyrate and hydroxyl, which is applied in the field of organic compound preparation, can solve the problems of difficult recovery of solvent dioxane, increased difficulty of industrial operation, and harsh reaction conditions, so as to reduce the risk of coronary heart disease and cardiovascular disease Occurrence, promote animal muscle growth, reduce the effect of content

Inactive Publication Date: 2003-05-14
MANTE SHANGHAI BIAOLOGICAL SCI TECH
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Problems solved by technology

[0005] There are defects in these two methods: the yield of the first route is very low, and the reaction conditions are harsh; a large amount of solvent dioxane used in the second route is difficult to recycle, causing environmental pollution and cost increase, and a large amount of ethanol is used to repeat the process repeatedly. Crystallization, increasing the difficulty of industrial operation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Prepare HMB-Ca according to above-mentioned preparation method, it is characterized in that,

[0022] The consumption of NaOH and water in the first step is 100g and 400g respectively;

[0023] Diacetone alcohol, water, NaHSO in the second step 3 The dosages of HCl and HCl are 46.4g, 120g, 8g and 120g respectively, and the dosage of isobutanol is 150g each time;

[0024] Water and Ca(OH) in the third step 2 The dosages are 120g and 14.8g respectively, and the product HMB-Ca 27.2g is obtained.

[0025] The present invention is used for preparing HMB-Ca. The product is not easily destroyed in the body of the animal, and enters the intestinal tract through the stomach to be absorbed and enter the circulatory system. It can promote animal muscle growth, enhance mammalian immune function, help the human body maintain a certain level of nitrogen, or reduce the content of cholesterol and low-density lipoprotein (LDL) in human blood, thereby reducing the occurrence of coron...

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Abstract

The present invention belongs to an organic compound preparing technology. Beta-hydroxyl-beta-methyl butyric calcium (HMB-Ca) is prepared using 4-methyl-4-hydroxy-2-propione as raw material and wateras solvent and through haloform reaction in water solution of NaOBr, acidification, isobutanol extraction, reaction of HMB acid in isobutanol extract with Ca(OH)2 to produce salt HMB-Ca. The said process has high product purity and less environmental pollution. The product HMB-Ca may be used in promoting the growth of muscles, strengthening immunity, reducing cholesterin and low-density lipoprotein level, preventing coronary heart disease and cardiac vascular disease, strengthening body's nitrogen-fixing capacity and maintaining body's protein level.

Description

technical field [0001] The invention relates to a preparation method of β-hydroxy-β-methylbutyrate calcium, which is abbreviated as HMB-Ca, and belongs to the technical field of organic compound preparation. The structural formula of HMB-Ca is: Background technique [0002] HMB calcium salt can be used to promote animal muscle growth, enhance mammalian immunity, reduce cholesterol and low-density lipoprotein (LDL) levels in humans to reduce the occurrence of coronary heart disease and cardiovascular disease, and also help enhance human nitrogen-fixing ability, maintain The protein level in the body is therefore widely used. At present, there are two main methods for the synthesis of HMB-Ca: 1. Free radical reaction: [0003] Using tert-butanol as raw material, ferrous sulfate and hydrogen peroxide as free radical initiators, introducing CO gas into the aqueous solution of sulfuric acid to prepare HMB acid, and then with Ca(OH) 2 A salt. Since it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C59/01
Inventor 王小曾汤杰杨帆
Owner MANTE SHANGHAI BIAOLOGICAL SCI TECH
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