Application of pearl and fructose composition in preparation of lozenges for preventing and treating oral ulcer

Abstract

The invention relates to a preparation method for lozenges for preventing and treating oral ulcer, in particular to application of a pearl powder or pearl layer powder and crystalline fructose composition in preparing of the oral ulcer lozenges. The oral lozenges capable of preventing and treating the oral ulcer consists of 1-2 parts of pearl layer powder and 2-5 parts of crystalline fructose andhave the good preventing and treating effects on the multiple and recurrent oral ulcer. The invention further discloses a formula and production technology for preparing the lozenges through the method that several vitamins and traditional Chinese medicine constituents, such as traditional Chinese medicine radix glycyrrhizae, fructus mume, exocarpium citri rubrum, dandelions and honeysuckle, withthe anti-inflammatory and antimicrobial effects are added into the composition. The lozenges for preventing and treating the oral ulcer through the preparation method have the effects of being antibacterial, anti-inflammatory, analgesic and capable of promoting ulcer healing, can be clinically used for prevention and treatment of the oral ulcer caused by various reasons, and can also be used for prevention and treatment of oral inflammation such as gingival tumefaction, pharyngitis, laryngitis and amygdalitis.

Description

technical field [0001] The invention relates to a preparation method of oral ulcer prevention and treatment buccal tablets, in particular to the application of pearl powder or nacre powder and crystalline fructose composition in the preparation of oral ulcer buccal tablets. Background technique [0002] Oral ulcer is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip or corner of the mouth mucosa. Oral ulcers that occur on the inside of the lips or in the corners of the mouth are generally single, relatively large and deep, like a large pit, and the bottom is slightly uneven. The course of this type of oral ulcer is relatively long, and scars can be left after healing, which is the most headache problem for patients. Oral ulcers that occur on the tongue and tongue abdomen are also called tongue ulcers. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect ea...

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of existing medicines for the treatment of oral ulcers are: antibiotics and glucocorticoids are the main chemical medicines only for anti-inflammation and pain relief for symptoms, and chemical cauterization can reduce the ulcer surface, but the side effects are very large, and cannot be fundamentally treated. Addresses mouth ulcer flare-ups

Traditional Chinese medicine powders and powder sprays are mostly formulated with medicinal powder or crude extract dry powder. The taste is not good, it is not easy to form a protective layer on the surface of the ulcer, and the dosage is not easy to control when administering; the medicine film has a small drug load , and the ulcer surface in the oral cavity is relatively large, and it is not suitable to be administered as a film when there are multiple ulcers; the drug concentration of the gargle is low, and the retention time in the oral cavity is short, so it is not easy to produce drug effect

Most of the buccal tablets currently used to treat oral ulcers in the market are compressed with extracts extracted from bitter and astringent medicinal materials, which have poor taste when taken orally, poor patient compliance, low oral bioavailability, and slow absorption of dosage forms. , sucrose, starch and other auxiliary materials are easy to adhere to the ulcer surface and become the medium for bacterial growth, causing a large number of bacteria to proliferate on the ulcer surface, making the ulcer surface difficult to heal

Therefore, the original varieties of medicines for the treatment of oral ulcers cannot meet the needs of the oral ulcer population in the society, so the clinical use has been greatly restricted.