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Acetaminophen and tramadol co-soluble compound analgesic oral liquid

An analgesic oral liquid and acetaminophen technology, which can be applied in the directions of non-central analgesics, pharmaceutical formulations, dispersion liquid delivery, etc., can solve the problems of patient burden, difficulty in using acetaminophen and tramadol compound oral liquid, etc.

Inactive Publication Date: 2019-08-13
保瑞药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned excessively high liquid volume will bring a great burden to the elderly, severe patients and patients with dysphagia, which makes it difficult for the above-mentioned patients to use such a large amount of oral liquid dosage forms of acetaminophen and tramadol compound oral liquid

Method used

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  • Acetaminophen and tramadol co-soluble compound analgesic oral liquid
  • Acetaminophen and tramadol co-soluble compound analgesic oral liquid
  • Acetaminophen and tramadol co-soluble compound analgesic oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] This example is about judging whether the co-dissolution of acetaminophen and tramadol has been completed and presented as a "clear and transparent solution". Whether it appears as a "clear and transparent solution" is judged by visual identification. After each formulation is prepared in the transparent centrifuge tube and left to stand for 24 hours, the bottom of the centrifuge tube is visually observed. If there is no sediment or floating matter at the bottom of the centrifuge tube, it is judged as "clear and transparent solution".

[0020] If the formation of powdery precipitates or cotton flocs is observed at the bottom of the centrifuge tube, it is judged as "incompletely dissolved".

[0021] If the formula is clear and transparent when the transparent centrifuge tube is prepared, but after standing for 24 hours, a precipitate with crystal form is observed at the bottom of the centrifuge tube, then it is judged as "recrystallization". In addition, in order to fu...

Embodiment 2

[0025] This example is about the manufacture of the co-solvent of acetaminophen and tramadol and the determination of whether it is a "clear and transparent solution". In this embodiment, glycerin and pure water are used as the main components of the solvent system, and propylene glycol and different polyethylene glycols (Polyethylene glycol hereinafter referred to as PEG) are used as co-solvents. The PEGs used in this embodiment are PEG400, PEG1000 and PEG3550 (polyethylene glycol 400, polyethylene glycol 1000 and polyethylene glycol 3550). When preparing, first mix pure water with glycerin and / or propylene glycol to form a uniform mixed solution, then slowly add acetaminophen, tramadol and other ingredients and use ultrasonic vibration to dissolve them. This embodiment judges whether it is a "clear and transparent solution" by the method shown in the foregoing embodiment 2, and exemplifies the following formulas 37, 39 to 43:

[0026] Recipe 37 weight % by weig...

Embodiment 3

[0045]This example is about the manufacture of acetaminophen and tramadol co-solvent and the determination of whether it is a "clear and transparent solution". In this embodiment, glycerin and pure water are used as the main components of the solvent system, and PEG400 is used as a co-solvent. When preparing, first mix pure water and glycerin to form a homogeneous mixed solution, then slowly add acetaminophen, tramadol and other ingredients and use ultrasonic vibration to dissolve them. This embodiment judges whether it is a "clear and transparent solution" by the method shown in the foregoing embodiment 1, and exemplifies the following formula 46:

[0046] Recipe 46 weight % by weight Acetaminophen 1625.00mg 5.45％ tramadol hydrochloride 187.50mg 0.63％ glycerin 14639.70mg 49.11％ PEG400 10152.00mg 34.06％ pure water 2794.00 mg 9.37％ Sucralose 231.00mg 0.77％ pineapple spice 115.00mg 0.39％ Yellow Pigment No...

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PUM

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Abstract

The invention relates to an acetaminophen and tramadol co-soluble compound analgesic oral liquid. The oral liquid is prepared from by weight, 1.447-6.702% of acetaminophen, 0.167%-0.773% of tramadol and 90.828%-98.02% of a solution system comprising glycerol, pure water and polyethylene glycol which independently accounts for 17-65% by weight, wherein the total weight percentage of the liquid is counted as 100%. The oral liquid is used for solving the problem that oral lozenge analgesics are difficult to use because it is difficult to swallow the analgesics.

Description

technical field [0001] The invention relates to a compound analgesic oral liquid co-dissolved with acetaminophen and tramadol, in particular to a compound analgesic oral liquid co-dissolved with acetaminophen and tramadol. Background technique [0002] Pain management has always been an important topic in medicine. As far as compound painkillers are concerned, acetaminophen (acetaminophen, paracetamol, also known as "parahydroxyacetanilide", "acetaminophen" or "paracetamol") and tramadol (tramadol) known in the prior art can be formulated The compound oral lozenge, and its compound ingredients have a synergistic effect, which is better than the effect of general combination therapy, and has lighter side effects. [0003] Age factors and symptoms of different acute and chronic conditions may cause dysphagia in patients. For example: factors such as aging, dementia, head and neck surgery, side effects of radiation therapy or chemotherapy, or gastrointestinal diseases, or eve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K31/167A61K31/137A61P29/00
CPCA61K9/0095A61K31/137A61K31/167A61K47/10A61K2300/00
Inventor 陈世民赖淳珣林盈谷盛保熙
Owner 保瑞药业股份有限公司
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